Long-term effects on growth of an energy-enhanced parenteral nutrition in preterm newborn: A quasi-experimental study

Terrin, Gianluca; Coscia, Alessandra; Boscarino, Giovanni; Faccioli, F.; Chiara, Maria Di; Greco, Carla; Onestà, Elisa; Oliva, Salvatore; Aloi, Marina; Dito, Lucia; Cardilli, Viviana; Regoli, Daniela; Curtis, Mario De

doi:10.1371/journal.pone.0235540

Cited by 18 publications

(22 citation statements)

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“…Data on survival, morbidity, and duration of hospital stay were collected in a separate and codified data form. Diagnosis of the main neonatal morbidities was performed according to the standard criteria by physicians unaware of the study design and aims as previously described ( 26 , 27 ). Nutritional management was performed as previously described ( 24 , 26 , 28 ).…”

Section: Methodsmentioning

confidence: 99%

“…Diagnosis of the main neonatal morbidities was performed according to the standard criteria by physicians unaware of the study design and aims as previously described ( 26 , 27 ). Nutritional management was performed as previously described ( 24 , 26 , 28 ). Hypotension was defined as any mean blood pressure value below the infant's postmenstrual age ( 29 ).…”

Section: Methodsmentioning

confidence: 99%

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Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

et al. 2020

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Introduction: Echocardiography (ECHO) with color flow Doppler is considered as the gold standard to identify a hemodynamic patent ductus arteriosus (hs-PDA). However, the optimal diagnostic and therapeutic management for newborns with hs-PDA is still controversial. We aimed to investigate two clinical strategies: (1) targeted treatment based on ECHO criteria and (2) treatment based on ECHO criteria in addition to clinical signs and symptoms.Materials and Methods: This is a cohort study including all neonates consecutively admitted in the Neonatal Intensive Care Unit of University La Sapienza in Rome, with gestational age <32 weeks or body birth weight <1,500 g and with a diagnosis of hs-PDA as confirmed by ECHO evaluation performed within 72 h of life. We classified the babies in two cohorts: (A) pharmacological treatment immediately after ECHO screening and (B) pharmacological therapy for PDA was administered when the relevance of a hs-PDA was associated with clinical signs of hemodynamic instability.Results: We considered as primary outcome newborns who survived without any morbidities (A: 48.1% vs. B: 22.2%, p = 0.022). In particular, we found that the rate of intraventricular hemorrhage stage ≥2 was increased in cohort B (A: 3.7% vs. B 24.4%, p = 0.020). A multivariate analysis showed that assignment to cohort A independently influences the primary outcome.Conclusions: Adopting an hs-PDA management option based on ECHO-directed therapy regardless of symptoms may reduce the morbidity and improve the survival of very low birth weight infants.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

et al. 2020

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“…Diagnosis of the main neonatal morbidities were performed according to the standard criteria, by physicians unaware of the study design and aims, as previously described [18][19][20]. Nutritional management was performed as previously described [18,[21][22][23]. We collected data on morbidity and duration of hospital stay in a separate and codi ed data form.…”

Section: Data Collectionmentioning

confidence: 99%

Morbidity Associated with Patent Ductus Arteriosus in Preterm Newborns: A Retrospective Case-Control Study

Terrin

Chiara

Boscarino

et al. 2020

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Introduction: Association between persistency of a patent ductus arteriosus (PDA) and morbidity in preterm newborns is still controversial. We aimed to investigate the relation between PDA and morbidity in a large retrospective study.Methods: A case-control study including neonates consecutively admitted to the Neonatal Intensive Care Unit (NICU), with gestational age (GA) ≤ 32 weeks or body birth weight (BW) ≤ 1500 g, over a 5-year period. Newborns were divided into Cases and Controls, according with the presence or absence of a hemodynamically significant PDA (hs-PDA).Results: We enrolled 85 Cases and 193 Controls. Subjects with hs-PDA had significantly (p<0.001) lower GA (26.7 w, 95%CI 27.1-28.0 vs. 30.1 w, 95%CI 29.7-30.4), BW (1024 g, 95% CI 952-1097 vs. 1310 g 95%CI 1263-1358) and an increased morbidity (60.0% vs. 18.7%). In a sub-group of extremely preterm newborns (GA < 29 weeks and BW < 1000 g), the rate of BPD was significantly increased in Cases (31.7%) compared with Controls (5.9%, p=0.033). Multivariate analysis showed that morbidity significantly depended on hs-PDA, GA and BW, and that, in extremely preterms, the hs-PDA represented an independent risk factor for BPD.Conclusions: The presence of hs-PDA seemed to increase the risk of morbidity in very low birth weight (VLBW) infants. In extremely preterm newborns, the risk of bronchopulmonary dysplasia (BPD) depended on the occurrence of hs-PDA.

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“…Data on survival, morbidity, and duration of hospital stay were collected in a separate and codified data form. Diagnosis of the main neonatal morbidities was performed according to the standard criteria by physicians unaware of the study design and aims as previously described (26,27). Nutritional management was performed as previously described (24,26,28).…”

Section: Data Collectionmentioning

confidence: 99%

“…Diagnosis of the main neonatal morbidities was performed according to the standard criteria by physicians unaware of the study design and aims as previously described (26,27). Nutritional management was performed as previously described (24,26,28). Hypotension was defined as any mean blood pressure value below the infant's postmenstrual age (29).…”

Section: Data Collectionmentioning

confidence: 99%

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Long-term effects on growth of an energy-enhanced parenteral nutrition in preterm newborn: A quasi-experimental study

Abstract: To assess the best energy intake in Parenteral Nutrition (PN) for preterm newborns, considering both possible benefits for growth and risk of complications. Methods Quasi-experimental study comparing two cohorts of newborns, receiving Energy-Enhanced vs.

Cited by 18 publications

References 32 publications

Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study

Morbidity Associated with Patent Ductus Arteriosus in Preterm Newborns: A Retrospective Case-Control Study

Table_1.DOCX

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