Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy

Antoniou, Tony; Raboud, Janet; Kovacs, Colin; Diong, Christina; Brunetta, Jason; Smith, Graham; Halpenny, Roberta; Beninger, Francis; Loutfy, Mona

doi:10.1080/09540120902814379

Cited by 14 publications

(14 citation statements)

References 16 publications

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“…It can also affect their adherence to medications. There have been several studies that have sought to define the impact of lipodystrophy on HRQOL [148, 150–154] as well as studies that have looked at interventions for lipodystrophy [150, 155–167]. …”

Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

“…The injectables currently in use for lipoatrophy treatment include polyacrylamide gel and hyaluronic acid. The majority of the studies have demonstrated a trend toward improvement in HRQOL scores for these patients, though not all were statistically significant, with improvements seen in the mental health component and social functioning domains especially [155, 160–162], though improvement was also seen in the physical domains as well [155]. These studies have used both HIV-specific HRQOL tools such as the MOS-HIV [155, 165] as well as dermatologic and body image-specific tools such as the ABCD or Dermatologic Life Quality Index (DLQI) [158, 159, 163, 164].…”

Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

“…The majority of the studies have demonstrated a trend toward improvement in HRQOL scores for these patients, though not all were statistically significant, with improvements seen in the mental health component and social functioning domains especially [155, 160–162], though improvement was also seen in the physical domains as well [155]. These studies have used both HIV-specific HRQOL tools such as the MOS-HIV [155, 165] as well as dermatologic and body image-specific tools such as the ABCD or Dermatologic Life Quality Index (DLQI) [158, 159, 163, 164]. In addition to improvement in HRQOL, many of these studies have looked at depression subscales and have also demonstrated improvements in patients who are treated for lipodystrophy [157, 158, 160, 164].…”

Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

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Health-related Quality of Life Assessment after Antiretroviral Therapy: A Review of the Literature

Gakhar

Kamali

Holodniy

2013

Drugs

119

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Antiretroviral (ARV) treatment for HIV infection has resulted in significant improvement in immunologic and virologic parameters, as well as a reduction in AIDS-defining illnesses and death. Over 25 medications are approved for use, usually in combination regimens of three or four ARVs. Several ARVs are now available as combinatorial products, which have been associated with better adherence. However, while ARV therapy has prolonged life, ARVs also pose a challenge for quality of life as they can cause significant side effects in addition to the potential for drug toxicity and interaction. Given the many complications, side effects and symptoms of HIV/AIDS in addition to associated medical and psychiatric co-morbidities, the need to understand and assess how these interactions may affect health-related quality of life (HRQOL) has grown. Numerous instruments (some validated, others not) are available and have been applied to understanding how ARV treatment affects HRQOL in those with HIV infection, both in clinical trials and clinical practice. In general, ARV treatment improves HRQOL, but this is dependent on the population being studied, the HRQOL instrument being used and the timeframe during which HRQOL has been studied. This article provides a review of the literature on quality of-life assessment as it relates to ARV treatment in developed countries and briefly reviews the HRQOL instruments used, how they have been applied to ARV utilization, and where future research should be applied in HRQOL assessment and HIV infection.

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Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

Section: Co-morbidities/side Effects and The Effect On Hrqolmentioning

confidence: 99%

See 1 more Smart Citation

Health-related Quality of Life Assessment after Antiretroviral Therapy: A Review of the Literature

Gakhar

Kamali

Holodniy

2013

Drugs

119

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“…Review of early literature surrounding Bio‐Alcamid suggested good results with minor complication rates 10, 11. Since then it has been used extensively in HIV‐associated facial lipoatrophy with high patient satisfaction rates of up to 95% and improved quality of life using validated surveys 12–15. However, with any synthetic material, the risk of inflammatory reactions, material migration, infection, and difficult removal exists.…”

Section: Introductionmentioning

confidence: 99%

Large needle suction aspiration of permanent fillers

Wilson¹,

Ellis²

2011

The Laryngoscope

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Temporary injectable fillers have become so widely accepted within the cosmetic medical industry that permanent fillers with longer lasting effects are fast gaining popularity. Both patients and physicians alike have eagerly sought a product to minimize the inconvenience and cost of repeated injections. However, the fear is that the use of permanent fillers may lead to permanent problems. We describe here an in-office technique to remove permanent injectable fillers that achieves consistent, natural results with minimal risk of scarring.

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“…Not specified/ not known [142] Prospective study (n = 9), 24 months follow-up # Only mild transient adverse events (e.g., modest inflammatory reaction, edema)…”

Section: Keratoacanthoma-like Reactionmentioning

confidence: 99%

Clinical data on injectable tissue fillers: a review

Vries

Geertsma

2013

Expert Review of Medical Devices

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Treatment with injectable tissue fillers for aesthetic purposes is increasingly popular. In parallel with this success, questions related to the safety of these treatments and the products involved are being raised more prominently. To gain insight in the safety aspects of injectable tissue fillers, we performed a literature review to collect studies reporting clinical data of injectable tissue fillers. We found several case reports where serious complications after more than three years are described. However, there are only a limited number of well-defined prospective clinical studies available with follow-up periods longer than three years. Furthermore, causes of complications, that is, treatment or product related, are often not specified in literature. Considering the intended functional period of fillers in combination with the known occurrence of long-term complications, there is a need for well-defined prospective clinical studies. In order to be able to discriminate between product failure (a product safety issue) or application methodology (a physician expertise or training issue), better identification of observed complications and whether they are product or treatment related, is needed. For the safe use of the fillers it is important that treatment with injectable tissue fillers is performed by a trained physician, who knows the product specifications and its applications. . Moreover, it is expected that due to increase in life expectancy, the demand for anti-aging treatments, like tissue augmentation with injectable tissue fillers, will grow [2]. Their success has been attributed to the fact that treatments with injectable tissue fillers are fast and appear to be relatively easy [2]. Only a relatively 'simple' subcutaneous injection is needed. Today, various injectable tissue fillers with different characteristics are available, for example, duration of the effect, material type and intended anatomical location.Although the application of an injectable tissue filler seems to be relatively simple and safe, reports of serious adverse effects have appeared in the literature [2][3][4][5][6][7][8]. Estimates of the occurrence of severe complications after treatment with various types of injectable tissue fillers range between 1:80 and 1:50,000 patients [9,10]. Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,13-15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks. A more severe short-term complication is necrosis [5,16]. Necrosis occurs immediately or within a few days if blood vessels are obstructed by the filler material or if they are injured during the treatment [17]. Mid-term complications such as delayed inflammatory reactions, ulceration and granuloma reaction may occur after 2-12 months. I...

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Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy

Cited by 14 publications

References 16 publications

Health-related Quality of Life Assessment after Antiretroviral Therapy: A Review of the Literature

Health-related Quality of Life Assessment after Antiretroviral Therapy: A Review of the Literature

Large needle suction aspiration of permanent fillers

Clinical data on injectable tissue fillers: a review

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