Long-Term Efficacy of Captopril (SQ 14,225) In 2-Kidney Renal Hypertensive Rats

Antonaccio, Michael J.; Rubin, Bernard; Horovitz, Zola P.; Mackaness, G. B.; Panasevich, Robert

doi:10.3109/10641967909068621

Cited by 21 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that captopril did not lower the blood pressure in 2-KHR to the same basal level as the control under similar conditions has also been observed in other studies (Mann et al, 1978;Antonaccio et al, 1979;Hollenberg and Williams, 1979). The relative differences bet ween the 'apparent' correlation profiles of 2-KHR and 1-KHR may represent a relative difference in the contribution by the vascular factors to the elevated blood pressure which is independent of the contribution by the reninangiotensin mechanism.…”

Section: Correlation Between Plasma Membrane Abnormalities and Blood supporting

confidence: 61%

Characteristics of Arterial Plasma Membrane in Renovascular Hypertension in Rats

Kwan¹,

Belbeck²,

Daniel³

1980

J Vasc Res

View full text Add to dashboard Cite

Protein content, enzymatic activites and Ca²⁺ accumulation capacities were studied in plasma membrane fractions isolated from mesenteric arteries of rats made hypertensive by renal artery stenosis with and without contralateral nephrectomy, i.e., one-kidney, one clip (1-KHR) and two-kidney, one clip (2-KHR) hypertension, respectively. Both types of renovascular hypertension showed similar vascular plasma membrane abnormalities which included increased total protein contents, enhanced alkaline phosphatase activities and reduced ATP-dependent Ca²⁺ accumulation compared to control values. The altered alkaline phosphatase activity and ATP-dependent Ca²⁺ accumulation appeared to be associated with blood pressure elevation in both types of hypertension and may be related to the elevation of blood pressure insensitive to captopril (SQ 14,225) in 1-KHR and 2-KHR. These results are consistent with the current concept of biochemical abnormalities of arterial smooth muscle in the development of renovascular hypertension in rats in addition to the involvement of the renin-angiotensin system.

show abstract

Section: Correlation Between Plasma Membrane Abnormalities and Blood supporting

confidence: 61%

Characteristics of Arterial Plasma Membrane in Renovascular Hypertension in Rats

Kwan¹,

Belbeck²,

Daniel³

1980

J Vasc Res

View full text Add to dashboard Cite

show abstract

“…2 -IM3 In particular, captopril, an orally active inhibitor of ACE, normalizes blood pressure and prevents the development of hypertension in adult SHR. 13 M Moreover, captopril is very effective in reducing blood pressure in both acute and chronic one and two-kidney one clip hypertensive dogs and rats." It is curious that captopril and other ACE inhibitors are dramatically effective in socalled "normal renin" hypertension whereas other agents that disrupt this system by other mechanisms are ineffective.…”

mentioning

confidence: 99%

Vascular wall renin in spontaneously hypertensive rats. Potential relevance to hypertension maintenance and antihypertensive effect of captopril.

Asaad¹,

Antonaccio²

1982

Hypertension

146

View full text Add to dashboard Cite

SUMMARY Relationships among systolic blood pressure (SBP), plasma renin activity (PRA), arterial renin concentrations (ARC), and venous renin concentrations (VRC) were examined in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats before and after treatment with captopril. The ARC was elevated in SHR relative to WKY whereas VRC was not. Similarly, ARC was related to SBP (/• = 0.69, p < 0.01) whereas PRA was not (r = 0.04). Captopril (100 mg/kg daily by mouth for 8 days) decreased blood pressure significantly in both SHR and WKY. PRA as well as ARC and VRC were all increased by captopril. Bilateral nephrectomy virtually eliminated PRA but ARC was not significantly reduced over a 24-hour period. Bilateral nephrectomy also markedly attenuated the acute antihypertensive effects of captopril in SHR; however, a modest effect was still apparent. It is suggested that ARC in SHR, being higher than in WKY, may play a role in the genesis or maintenance of hypertension in this model. Furthermore, the effects of captopril in both intact and nephrectomized SHR may be related to the ability of captopril to inhibit the vascular formation of angiotensin II. Finally, vascular renin is probably not renal in origin and responds to typical feedback inhibition as unmasked by captopril administration. high plasma renin activity (PRA) such as acute twokidney renal hypertension, agents that interfere with the formation of, or receptor activation by, angiotensin II (All) are very effective in reducing blood pressure. Thus, renin inhibitors, ]~2 angiotensin-converting enzyme (ACE) inhibitors, 3 "* and All antagonists 9 have all been shown to either prevent the development of twokidney renal hypertension or reduce blood pressure shortly after the development of this form of hypertension. In chronic two-kidney one clip hypertension as well as one-kidney one clip and genetic hypertension, however, the relationship between PRA in the maintenance of hypertension and the antihypertensive effectiveness of inhibitors of the renin-angiotensin system is no longer clear. Thus, All antibodies and receptor antagonists do not substantially reduce blood pressure in chronic one-or two-kidney one clip hypertension or in spontaneously hypertensive rats (SHR) which are models that have normal or low PRA.

show abstract

“…Moreover, we have reported that guanethidine was capable of further decreasing blood pressure to normal in chronic (10-month) 2K-RHR receiving maximally effective doses of captopril and hydrochlorothiazide. 17 Although Grewal and Kaul 6 found that 6-OH dopamine prevented the development of two-kidney two clip renal hypertension in 80% of weanling rats, they could show no significant inhibition when adult rats were used. A major difference between our study and others was our protracted use of 6-OH dopamine to prevent the regeneration of sympathetic neurons observed after only short-term treatment with 6-OH dopamine."…”

Section: Sympathoadrenal Systemmentioning

confidence: 98%

“…Captopril was able to normalize blood pressure in vehicletreated 6-week 2K-RHR as previously shown in other studies. 17 -" However, despite significantly higher MBP in 12-week 2K-RHR, captopril was not as effective in decreasing MBP as in 6-week 2K-RHR, suggesting that some additional mechanism became operative in these rats, probably the sympathoadrenal system (see below). In rats that were either sympathectomized with 6-OH dopamine, adrenalmedullectomized, or had a combination of both procedures, captopril was still capable of significantly decreasing MBP further.…”

mentioning

confidence: 98%

“…However, this is in distinct contrast to the effectiveness of guanethidine in normalizing blood pressure in established renal hypertension. 17 Also, these authors did not take into account the presence of the adrenal glands and their potential participation in renal hypertension. Thus, the present study was designed to examine the relative roles of the sympathetic nerves and the adrenal gland individually, and in conjunction (sympathoadfenal system), on the development of two-kidney one clip renal hypertension in rats, as well as the role of the renin-angiotensin system in this model.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.

Antonaccio¹,

Ferrone²,

Waugh³

et al. 1980

Hypertension

View full text Add to dashboard Cite

SUMMARYThe relative roles of tbe sympathetic nerrous system and renin-angiotefisin system in the development of two-kidney renal hypertension were studied using four groups of rats: Group I = vehicle control; Group II = 6-OH-dopamine (2 weeks prior to renal clipping then weekly throughout the study); Group III = adrenal medullectomy plus vehicle; Group IV = o-OHndopamlne plus adrenal medullectomy. Six weeks after clipping of a single renal artery, plasma renln activity (PRA) was comparably elevated in all groups. However, mean blood pressure (MBP) of Group II was lower than that of Group I controls (154.

show abstract

Long-Term Efficacy of Captopril (SQ 14,225) In 2-Kidney Renal Hypertensive Rats

Cited by 21 publications

References 13 publications

Characteristics of Arterial Plasma Membrane in Renovascular Hypertension in Rats

Characteristics of Arterial Plasma Membrane in Renovascular Hypertension in Rats

Vascular wall renin in spontaneously hypertensive rats. Potential relevance to hypertension maintenance and antihypertensive effect of captopril.

Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.

Contact Info

Product

Resources

About