Long-term efficacy of dupilumab in severe asthma by baseline oral corticosteroid dose
Christian Domingo,
Klaus F. Rabe,
David Price
et al.
Abstract:BackgroundDupilumab has been shown to improve clinical outcomes long term while reducing oral corticosteroid (OCS) dose in patients with severe OCS-dependent asthma. Thispost hocanalysis assesses the impact of OCS dose at baseline (≤10 or >10 mg·day−1) on long-term outcomes of dupilumab treatment.MethodsAnnualised severe asthma exacerbation rates, forced expiratory volume in 1 s (FEV1), measures of asthma control and quality of life (QoL), and OCS dose were evaluated in patients from the phase 3 VENTURE tri… Show more
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