Long-Term Efficacy of Haloperidol in Autistic Children: Continuous versus Discontinuous Drug Administration

Perry, Richard; Campbell, Magda; Adams, Phillip; Lynch, Nona; Spencer, Elizabeth K.; Curren, Elizabeth L.; Overall, John E.

doi:10.1097/00004583-198901000-00016

Cited by 113 publications

(33 citation statements)

References 10 publications

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“…In a study of 60 children (aged 2.3-7.9 years) with autism, previous responders to haloperidol were enrolled in the study and randomized to 6 months of either continuous or discontinuous (5 days on, 2 days off) administration of haloperidol (52). After 6 months of haloperidol treatment, subjects were given placebo for 4 weeks.…”

Section: Figurementioning

confidence: 99%

Antipsychotics in the treatment of autism

Posey¹,

Stigler²,

Erickson³

et al. 2008

J. Clin. Invest.

174

104

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Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

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Section: Figurementioning

confidence: 99%

Antipsychotics in the treatment of autism

Posey¹,

Stigler²,

Erickson³

et al. 2008

J. Clin. Invest.

174

104

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show abstract

“…Heretofore, the largest extended study of neuroleptic treatment for autistic disorder was the examination of the effects of haloperidol over a 6-month period. In that study (5), 60 children treated with a mean dose of 1.23 mg/day of haloperidol were classified as "good responders." After 6 months of treatment, 33 (63%) of 52 subjects were rated as "much improved."…”

Section: Discussionmentioning

confidence: 99%

Risperidone Treatment of Autistic Disorder: Longer-Term Benefits and Blinded Discontinuation After 6 Months

Aman¹,

Arnold²,

Lindsay³

et al. 2005

AJP

257

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Objective: Risperidone is effective for short-term treatment of aggression, temper outbursts, and self-injurious behavior in children with autism. Because these behaviors may be chronic, there is a need to establish the efficacy and safety of longer-term treatment with this agent.Method: The authors conducted a multisite, two-part study of risperidone in children ages 5 to 17 years with autism accompanied by severe tantrums, aggression, and/or self-injurious behavior who showed a positive response in an earlier 8-week trial. Part I consisted of 4-month open-label treatment with risperidone, starting at the established optimal dose; part II was an 8-week randomized, double-blind, placebo-substitution study of risperidone withdrawal. Primary outcome measures were the Aberrant Behavior Checklist irritability subscale and the Clinical Global Impression improvement scale.Results: Part I included 63 children. The mean risperidone dose was 1.96 mg/day at entry and remained stable over 16 weeks of open treatment. The change on the Aberrant Behavior Checklist irritability subscale was small and clinically insignificant. Reasons for discontinuation of part I included loss of efficacy (N=5) and adverse effects (N=1). The subjects gained an average of 5.1 kg. Part II included 32 patients. The relapse rates were 62.5% for gradual placebo substitution and 12.5% for continued risperidone; this difference was statistically significant.Conclusions: Risperidone showed persistent efficacy and good tolerability for intermediate-length treatment of children with autism characterized by tantrums, aggression, and/or self-injurious behavior. Discontinuation after 6 months was associated with a rapid return of disruptive and aggressive behavior in most subjects.

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“…De tous les neuroleptiques, seul l'halopéridol a été étudié de façon systématique pour l'autisme; sa supériorité au placebo pour améliorer des difficultés comportementales comme l'agressivité, l'irritabilité, l'hyperactivité (Campbell, 1978b;Campbell, 1982;Perry, 1989) a été démontrée à maintes reprises dans les études. Certains rapports indiquent des effets positifs sur l'apprentissage (Campbell, 1982), d'autres non (Lowell, 1989).…”

Section: Neuroleptiquesunclassified

Note clinique sur le traitement pharmacologique de l’autisme

Thivierge¹

2007

smq

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Cet article fait le point sur la pharmacologie de l'autisme et en survole rapidement l'utilité, F historique et les nouveautés. L'« autisme » ne fait référence à aucune pathophysiologie présentement connue. Et aucun médicament ou classe de médicaments ne peut prétendre guérir cette maladie, qui en recouvre plusieurs. Avant d'user de médicaments, efficaces pour soulager certains symptômes, il importe souvent de considérer le recours à des approches comportementales. Les développements en recherche font espérer que des médicaments pourront guérir ou prévenir cette maladie du cerveau.This article reviews the pharmacology of autism and briefly overviews its use, history and novelties. "Autism" does not refer to any pathophysiology currently known. And no drug or class of drugs can cure this illness which includes many. Before using drugs, efficient in relieving symptoms, it is important to consider the potential benefit of behavioral approaches. Developments in research give hope that drugs will cure or prevent this brain illness.Este articulo pone el acento en la farmacologia del autismo y râpidamente sobrevuela la utilidad, la historia y las novedades. El "autismo" no se refiere a ninguna fisiopatologia conocida en este momento. Ningún medicamento o clase de medicamentos puede pretender curar esta enfermedad, que encubre varias. Antes de usar medicamentos, eficaces para aliviar ciertos sintomas, conviene considerar el recurso a las terapéuticas ya probadas. Los desarrollos de la investigacion dejan créer que los medicamentos podrân curar o prévenir esta enfermedad cerebral

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Long-Term Efficacy of Haloperidol in Autistic Children: Continuous versus Discontinuous Drug Administration

Cited by 113 publications

References 10 publications

Antipsychotics in the treatment of autism

Antipsychotics in the treatment of autism

Risperidone Treatment of Autistic Disorder: Longer-Term Benefits and Blinded Discontinuation After 6 Months

Note clinique sur le traitement pharmacologique de l’autisme

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