2005
DOI: 10.1016/j.vaccine.2005.03.017
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Long-term efficacy of hepatitis B vaccine, booster policy, and impact of hepatitis B virus mutants

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Cited by 156 publications
(94 citation statements)
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“…25 It has been shown that vaccine induces active production of anti-HBs antibody accompanied by HBsAg-specific immunological memory that provide continuous protection in the absence of antibody. 17,18 The persistence of immunological memory over 5 years after primary vaccination is apparent from rapid increases in antibody level following booster vaccination, even in subjects who have lost antibodies. [26][27][28][29] This phenomenon clearly represents the presence of the immunological memory exist within the memory B lymphocytes that are induced during the first exposure to antigen, and upon a subsequent exposure to the same antigen, induces rapid production of specific antibody.…”
Section: 21mentioning
confidence: 99%
See 1 more Smart Citation
“…25 It has been shown that vaccine induces active production of anti-HBs antibody accompanied by HBsAg-specific immunological memory that provide continuous protection in the absence of antibody. 17,18 The persistence of immunological memory over 5 years after primary vaccination is apparent from rapid increases in antibody level following booster vaccination, even in subjects who have lost antibodies. [26][27][28][29] This phenomenon clearly represents the presence of the immunological memory exist within the memory B lymphocytes that are induced during the first exposure to antigen, and upon a subsequent exposure to the same antigen, induces rapid production of specific antibody.…”
Section: 21mentioning
confidence: 99%
“…[13][14][15][16] Some investigators have also suggested the need for a booster vaccination at 15 years after the completion of primary vaccination. 17,18 However, the determination of the protection duration after primary vaccination against HBV is important to evaluate whether booster vaccination may be necessary to extend protection through adulthood.…”
mentioning
confidence: 99%
“…[42][43][44][45][46][47][48] This may not always be the case, since loss of detectable antibodies following vaccination with hepatitis B vaccine has rarely been associated with breakthrough cases of clinical hepatitis B disease in the presence of hepatitis B virus exposure, as measured by hepatitis B core antibody ELISA. 49,50 However, the relevance of this observation to HPV disease is unknown; unlike hepatitis B virus, which is a blood-borne infection, HPV does not cause viremia or systemic ). Only samples that tested positive for the HPV antigen under analysis in both serum and CVS (i.e., double-positive samples) were analyzed.…”
mentioning
confidence: 98%
“…Studies suggest that long-term persistence of high anti-HBs levels, as well as immunological memory and the degree of protection from infection are associated with peak anti-HBs concentrations after vaccination [31,33,[42][43][44]. Several studies have shown that healthy individuals with an anti-HBs concentration <10 mIU/ml can be infected with hepatitis B, but mostly retain protection against chronic infection provided that they initially responded well to the vaccine [2,3,17,33,42,43].…”
Section: Discussionmentioning
confidence: 99%
“…According to published data, available vaccines induce a protective antibody response to hepatitis B surface antigen (anti-HBs) in about 95 % of vaccinees and confer long-lasting protection against hepatitis B infection in immunocompetent individuals [1][2][3][4][5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%