Long-Term Endothelial Cell Loss in Patients with Artisan Myopia and Artisan Toric Phakic Intraocular Lenses

Jonker, Soraya M.R.; Berendschot, Tos T. J. M.; Ronden, Annick E.; Saelens, Isabelle E.Y.; Bauer, Noël; Nuijts, Rudy M.M.A.

doi:10.1016/j.ophtha.2017.08.011

Cited by 84 publications

(88 citation statements)

References 33 publications

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“…Doors et al [ 26 ] found that a shallow ACD and smaller distance between the pIOL edge and the endothelium were risk factors for ECD loss. In a recent study, Jonker et al [ 27 ] reported that in a group of 507 eyes, ECD had decreased by ≥25% in 7.9% of them, and ECD was <1500 cells/mm 2 in 3.9% at 10 years after implantation. Risk factors for increased ECD loss were a shallow ACD and a smaller distance between the central and peripheral pIOL edge to the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Verisyse versus Veriflex Phakic Intraocular Lenses: Refractive Outcomes and Endothelial Cell Density 5 Years after Surgery

Yaşa

Ağca

2018

Journal of Ophthalmology

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Purpose To compare refractive stability, central endothelial cell density (ECD), and complications between Verisyse (Abbott Medical Optics, Netherlands) and Veriflex (Abbott Medical Optics, Netherlands) phakic intraocular lenses (pIOL) over five years. Methods We retrospectively reviewed the medical records of patients who underwent Verisyse or Veriflex pIOL implantation for surgical correction of myopia. Patients with a 5-year follow-up period were included in the study. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent of manifest refraction (SE), and ECD were compared between the groups preoperatively and 1, 3, and 5 years postoperatively. Results The study included 47 eyes in the Verisyse group and 50 eyes in the Veriflex group. There was no significant difference in mean SE, UDVA, CDVA, and ECD preoperatively or postoperatively. In both groups, there was a statistically significant myopic shift between 1-year and 5-year visits (−0.25 ± 0.30 D and −0.23 ± 0.48 D in the Verisyse and Veriflex groups, respectively). There was no significant difference between the groups in terms of efficacy and safety indexes at 5 years. ECD loss was highest during the first year (3.9% loss in the Verisyse group and 3.9% loss in the Veriflex group, p=0.670). At 5 years, the mean cumulative ECD losses in the Verisyse and Veriflex groups were 7.42% and 7.64%, respectively (p=0.709). Cataracts developed in 2.1% of the eyes in the Verisyse group and in 2.0% of those in the Veriflex group. No sight-threatening complications were observed. Conclusion Verisyse and Veriflex pIOLs are highly effective for treating high myopia up to 5 years after surgery. Longitudinal studies with longer follow-up periods are necessary to determine the endothelial safety profile.

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Section: Discussionmentioning

confidence: 99%

Verisyse versus Veriflex Phakic Intraocular Lenses: Refractive Outcomes and Endothelial Cell Density 5 Years after Surgery

Yaşa

Ağca

2018

Journal of Ophthalmology

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“…On the contrary, detection of an acute loss early after the surgery and stabilization after the 3-month visit suggests that the main reason for the cell loss is surgical trauma and that the pIOL does not induce a clinically significant amount of ECD loss by itself, at least in the patients included in this study . Previous studies show that a smaller ACD is a significant risk factor for increased ECD loss in both anterior and posterior chamber pIOLs [ 11 , 25 ]. Accordingly, it is routine in our clinic to implant pIOLs of any type in only patients who have a ACD greater than 3.00 mm and the minimum anterior chamber depth (ACD) in this study was 3.04 mm from the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Early Results with a New Posterior Chamber Phakic Intraocular Lens in Patients with High Myopia

Yaşa

Ürdem

Ağca

et al. 2018

Journal of Ophthalmology

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Purpose To report clinical results of a foldable, hydrophilic acrylic, single-piece, injectable, posterior chamber phakic intraocular lens (pIOL). Material and Methods Medical records of patients who underwent posterior chamber phakic IOL (Eyecryl Phakic IOL, Biotech Vision Care, Ahmedabad, India) implantation for surgical correction of myopia were retrospectively reviewed. Only patients with at least a one-year follow-up were included. Manifest refraction, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), endothelial cell density (ECD), and pIOL vault were analyzed at 1, 3, 6, and 12 months after surgery. Complications observed during and after surgery were also recorded. Results The study included 58 eyes of 29 patients. Mean patient age was 32 ± 7 years. Spherical equivalent of manifest refraction was −13.41 ± 3.23 D preoperatively and −0.44 ± 0.55 D postoperatively. Preoperative CDVA was 0.29 ± 0.71 logMAR. Postoperative UDVA and CDVA were 0.21 ± 0.66 and 0.15 ± 0.69 logMAR, respectively, at the 12-month visit. At the 12-month visit, the efficacy index was 1.20 and the safety index was 1.39. Mean ECD was 2713 ± 339 cells/mm2 at the preoperative visit and 2608 ± 362 cells/mm2 at the 12-month visit (3.9% loss, p < 0.001). ECD loss from 3 months to 12 months was not statistically significant. No significant cataract formation, significant endothelial cell loss, glaucoma, uveitis, or any other vision-threatening complication was observed. Conclusion Based on postoperative experience, we have found that Eyecryl Phakic IOL is safe and effective for treating high myopia.

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“…Silva et al 12 reported a drop in the mean ECD of 14.05% at 5 years in 26 eyes. Jonker et al 13 implanted 127 eyes with the Artisan pIOL. The ECD showed a total loss of 16.6% over10 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

<p>Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density</p>

Shaaban

2020

OPTH

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Purpose: To compare the effect of three different phakic intraocular lenses (pIOLs) on the corneal endothelial cell density (ECD). Patients and Methods: This was a prospective observational cohort study that included 60 eyes (30 patients) with axial myopia of −6.50 to −22.00 diopters (D). The Verisyse anterior chamber (AC) rigid iris fixated pIOL, the Veriflex (AC) flexible iris fixated pIOL, and the Visian posterior chamber (PC) implantable collamer lens (ICL) were implanted in three equal groups of patients. The effect of the three pIOLs on the ECD was compared over a follow-up period of one week, and one, three, and six months, and one, two, and three years. Specular microscopy was done to evaluate the cornea before the surgery and throughout the study. Changes were statistically analyzed and compared. Results: In the first three postoperative months, Verisyse and Veriflex pIOLs induced almost the same amount of endothelial cells loss of 10.3% and 10.6%, respectively, while ICLs showed endothelial cells loss of 3.5%. At the end of the three-year study, Veriflex pIOLs induced the highest rate of endothelial cell loss of 25%, while Verisyse and ICL lenses showed endothelial cells loss of 15.7% and 13.4%, respectively. The main effect of time and type of lens was statistically significant (p<0.001). Conclusion: All pIOLs cause a decrease in ECD. The AC pIOLs tend to be associated with more cell loss than PC pIOLs. Surgical insult is the important factor responsible for the early endothelial cell loss, while the material from which the pIOL is made may be an important factor for the continuous corneal endothelial cell loss over a long time.

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Long-Term Endothelial Cell Loss in Patients with Artisan Myopia and Artisan Toric Phakic Intraocular Lenses

Cited by 84 publications

References 33 publications

Verisyse versus Veriflex Phakic Intraocular Lenses: Refractive Outcomes and Endothelial Cell Density 5 Years after Surgery

Verisyse versus Veriflex Phakic Intraocular Lenses: Refractive Outcomes and Endothelial Cell Density 5 Years after Surgery

Early Results with a New Posterior Chamber Phakic Intraocular Lens in Patients with High Myopia

<p>Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density</p>

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