“…Inflammation mainly affects the posterior disc attachement (Holmlund & Axelsson, 1996;Leibur et al, 2010). Several inflammatory mediators play an important role in the pathogenesis of TMJ diseases as tumor necrosis factor (TNF ), interleukin-1 (IL-1 ), prostaglandin E 2 (PGE 2 ) , leukotrien B 4 (LkB 4 ), matrix metalloproteinases (MMP s ), serotonin-5-hydroxytryptamine (5-HT), (Alstergren et al, 1999;Voog et al, 2003b).…”