2022
DOI: 10.3390/biomedicines10102510
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Long-Term Excessive Dietary Phosphate Intake Increases Arterial Blood Pressure, Activates the Renin–Angiotensin–Aldosterone System, and Stimulates Sympathetic Tone in Mice

Abstract: Increased dietary phosphate intake has been associated with severity of coronary artery disease, increased carotid intima–media thickness, left ventricular hypertrophy (LVH), and increased cardiovascular mortality and morbidity in individuals with normal renal function as well as in patients suffering from chronic kidney disease. However, the underlying mechanisms are still unclear. To further elucidate the cardiovascular sequelae of long-term elevated phosphate intake, we maintained male C57BL/6 mice on a cal… Show more

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Cited by 5 publications
(3 citation statements)
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“…All phenotyping data are expressed as mean ± standard error of the mean (SEM). Sample sizes were determined by analysis based on data collected by our laboratory in published studies [ 22 , 51 , 52 ]. Statistical analysis of the data was carried out using GraphPad Prism software (GraphPad Software 8.3.0, San Diego, CA, USA).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…All phenotyping data are expressed as mean ± standard error of the mean (SEM). Sample sizes were determined by analysis based on data collected by our laboratory in published studies [ 22 , 51 , 52 ]. Statistical analysis of the data was carried out using GraphPad Prism software (GraphPad Software 8.3.0, San Diego, CA, USA).…”
Section: Methodsmentioning
confidence: 99%
“…RNA Isolation and Quantitative Real-Time PCR Hearts were harvested from mice and snap-frozen in liquid nitrogen. Total RNA was extracted from heart tissue using a TRI Reagent solution (Applied Biosystems, Thermo Fischer Scientific, Waltham, MA, USA) as described previously [51,52]. The purity and integrity of the extracted RNA were assessed using electrophoresis (Agilent Tapestation, Santa Clara, CA, USA).…”
Section: Tissue Harvesting and Histological Analysismentioning
confidence: 99%
“…On the other hand, a few studies tested the effect of high Pi on endocrine or cardiovascular endpoints under controlled experimental conditions in healthy participants and animals. In these studies, high phosphate intake caused a higher sympathetic nerve outflow, higher systolic blood pressure or bone loss [ 91 , 98–100 ]. Moreover, animal studies suggest that high Pi intake can cause left ventricular hypertrophy as well as kidney damage [ 45 , 101 ].…”
Section: Phosphate In Diseasementioning
confidence: 99%