2012
DOI: 10.4236/fns.2012.36098
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Long Term Excessive Zn Supplementation Induced Oxidative Stress in Wistar Rats Fed on Semi-Synthetic Diet

Abstract: The use of Zn as micronutrient in husbandry and agriculture practices and also in baby foods and multivitamin supplements have been increased during the last two decades. However, the effect of long term increasing Zn load on the oxidative stress in the body has not been worked so far. The supplementation of pharmacological dosage of Zn in otherwise Zn adequate diet was investigated with the aim if excess Zn in the diet triggers oxidative stress and its conesquence on enzymes of antioxidant defense system. In … Show more

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Cited by 4 publications
(5 citation statements)
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“…The improved ADG in zinc supplemented groups is consistent with the reports of Taneja [16] and Singh [17] in rats, who observed improved growth rate in rats fed basal diet containing 20ppm Zn as ZnSO 4 .7H 2 O throughout the experimental period (180 days), and growth ratereducedin 40 and 80ppm supplemented diets fed rats after 150 days of experiment. In present study, no such growth depression was observed in 36 and 48 ppm Zn supplemented rats.…”
Section: Effect Of Zinc On Body Weight and Feed Intakesupporting
confidence: 91%
See 1 more Smart Citation
“…The improved ADG in zinc supplemented groups is consistent with the reports of Taneja [16] and Singh [17] in rats, who observed improved growth rate in rats fed basal diet containing 20ppm Zn as ZnSO 4 .7H 2 O throughout the experimental period (180 days), and growth ratereducedin 40 and 80ppm supplemented diets fed rats after 150 days of experiment. In present study, no such growth depression was observed in 36 and 48 ppm Zn supplemented rats.…”
Section: Effect Of Zinc On Body Weight and Feed Intakesupporting
confidence: 91%
“…However, the reverse observed in 48ppm Zn supplemented group might be due hyper zinccaemea or due to altered Cu-Zn ratio. Though zinc is an essential trace element,there are some evidences that excess zinc can cause enhanced oxidative stress [21].The activities of Cu and Zn containing antioxidant enzymes including superoxide dismutase (SOD), cyto-chrome-C oxidase (CCO), catalase (CAT) and gluta-thione peroxidase (GPx) have been reported to diminish under Zn or Cu-deficiency or due to alteration in Cu-Zn ratio [22,23,24].Similar to present investigation, Singh, [17] reported that supplementation of excess zinc (40 and 80ppm Zn as ZnSO 4 .7H 2 O) in rats resulted in significant (P < 0.01) increase in oxidative stress markers (LPx) in liver and kidney than in the control group supplemented with 20ppm. Further, their high concentration in excess zinc supplemented groups coincided with enzymes of antioxidant defense system i.e.…”
Section: Effect Of Zinc On Antioxidant Enzymes and Oxidative Stress Msupporting
confidence: 82%
“…Hence, in excess, Zn +2 can become cytotoxic (Kim et al, 2020). Singh et al (2012) exposed rats to diet with 20, 40 and 80 mg/Kg of Zn+2 for 6 months and observed in blood increased TBARS, increased activity of CAT, SOD and GSH-Px enzymes, increased blood level of triglycerides, LDL, VLDL and decreased HDL for the two highest doses. These data were associated with higher concentration of Zn +2 and lower concentration of Cu +2 , Mg +2 and Mn +2 in liver and kidney of the animals, suggesting that excess of chronic Zn +2 may result in change of oxidative stress by altering the level of other minerals.…”
Section: Discussionmentioning
confidence: 99%
“…Por otro lado, metales como el cobre y zinc son metales traza que actúan en funciones catalíticas, estructurales y reguladoras de importancia para los procesos biológicos (Bost et al, 2016;Roohani, Hurrell, Kelishadi, & Schulin, 2013). El exceso de Zn puede promover síndromes metabólicos como: sobrepeso, hipertensión y dislipidemia en ratas Wistar (Singh, 2012). Altas concentraciones de Cu conducen a la generación de especies oxidativas altamente reactivas, modulando la proliferación de las células cancerígenas y el crecimiento de tumores, (Fortoul et al, 2015).…”
Section: Introductionunclassified