2019
DOI: 10.1634/theoncologist.2018-0280
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Long-Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High-Risk Bladder Cancer (Ta, Tis, T1, T2)

Abstract: Background. The aim of this study was to evaluate the efficacy and safety of chemoradiotherapy (RCT) combined with regional deep hyperthermia (RHT) of high-risk bladder cancer after transurethral resection of bladder tumor (TUR-BT). Materials and methods. Between 1982 and 2016, 369 patients with pTa, pTis, pT1, and pT2 cN0-1 cM0 bladder cancer were treated with a multimodal treatment after TUR-BT. All patients received radiotherapy (RT) of the bladder and regional lymph nodes. RCT was administered to 215 patie… Show more

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Cited by 35 publications
(22 citation statements)
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“…HSP70-activated NK cells destroy primary and metastatic tumor cells that express HSP70. HSP70 proteins released from dead tumor cells also increase the T-cell infiltration into the tumor (13,14).…”
Section: Discussionmentioning
confidence: 99%
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“…HSP70-activated NK cells destroy primary and metastatic tumor cells that express HSP70. HSP70 proteins released from dead tumor cells also increase the T-cell infiltration into the tumor (13,14).…”
Section: Discussionmentioning
confidence: 99%
“…In line with the increase in temperature, the cytotoxic effect of the chemotherapeutic agent increases. Hyperthermia increases the permeability of chemotherapeutic agents into the tumor by causing vasodilation in tumor vascularization (14,15).…”
Section: Discussionmentioning
confidence: 99%
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“…The HSP70-activated NK cells destroy primary and metastatic tumor cells that express HSP70. Following that, the HSP70 proteins released from dead tumor cells increase the T-cell infiltration into the tumor (13,14).…”
Section: Discussionmentioning
confidence: 99%
“…Overview of clinical applications of local, locoregional and whole-body heating techniques [55,[71][72][73][74]81,96,97,132,139,166,[199][200][201][202]. BO: Bone (metastases, osteoid osteoma)…”
mentioning
confidence: 99%