Long-term experiment to study the development, interaction, and influencing factors of DEXA parameters

Fuchs, Helmut; Gau, Christine; Hans, Wolfgang; Gailus‐Durner, Valérie; Angelis, Martin Hrabé de

doi:10.1007/s00335-013-9477-8

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DEXA is an accurate, high-throughput radiographic method for evaluating bone mineral density in live animals and can be employed in a longitudinal design taking multiple measurements of the same animal over time due to its low radiation exposure [37]. Before each DEXA scan, mice were weighed and anesthetized with 2.5% isoflurane via nose cone to provide immobilization for the duration of the 5-min scan.…”

Section: Methodsmentioning

confidence: 99%

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease

Crish

Smith

Wilson

2016

JAD

View full text Add to dashboard Cite

Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer’s disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced BMD translates to increased bone fracture risk, decreased quality of life, and increased mortality for AD patients. However, the mechanism responsible for this observation is unclear. We hypothesize that bone loss is an additional component of an AD prodrome-changes that emerge prior to dementia and are mediated by dysfunction of the central serotonergic pathways. We characterized the skeletal phenotype of htau mice that express human forms of the microtubule-associated protein tau that become pathologically hyperphosphorylated in AD. Using radiographic densitometry, we measured BMD in female and male htau mice from 2–6 months of age–time-points prior to the presence of significant tauopathy in the hippocampal/entorhinal regions characteristic of this model. We found a significantly reduced BMD phenotype in htau mice that was most pronounced in males. Using western blotting and immunofluorescence, we showed overall reduced tryptophan hydroxylase (TPH) protein in htau brainstem and a 70% reduction in TPH-positive cells in the dorsal raphe nucleus (DRN)–a pivotal structure in the regulation of the adult skeleton. Elevations of hyperphosphorylated tau (ptau) proteins were also measured in brainstem, and co-labeled immunofluorescence studies showed presence of ptau in TPH-positive cells of the DRN as early as 4 months of age in htau mice. Together, these findings demonstrate that reduced BMD occurs earlier than overt degeneration in a tau-based AD model and that pathological changes in tau phosphorylation occur in the serotonin-producing neurons of the brainstem raphe in these mice. This illuminates a need to define a mechanistic relationship between bone loss and serotonergic deficits in early AD.

show abstract

Section: Methodsmentioning

confidence: 99%

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease

Crish

Smith

Wilson

2016

JAD

View full text Add to dashboard Cite

show abstract

Evidence of Wnt/β-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease

Crish

Ball

Lin

et al. 2018

Neurobiology of Aging

View full text Add to dashboard Cite

Effects of Judo Training on Bones: A Systematic Literature Review

Ciaccioni

Condello

Guidotti

et al. 2019

Journal of Strength and Conditioning Research

View full text Add to dashboard Cite

The aim of this study was to provide a systematic literature review on the osteogenic effects of judo (PROSPERO: CRD42016041803). The online search was conducted according to the inclusion criteria: observational studies and clinical/interventional trials in English from inception to June 2016; bone health, mineral density (BMD), diameters, impact force and turnover markers (BTM) outcomes. Thirty-four studies were included and graded for their methodological quality ("fair" quality: 79.4%). The most used assessment method (44.1%) was X-ray absorptiometry. A positive association between judo and bone health/status emerged. Findings support site-specific BMD accrual in children, adolescents, adult athletes, and in pre- and post-menopausal women practitioners. BTM revealed a hypermetabolic status in high-level judo athletes. The osteogenic stimuli of judo seem to protect athletes from alterations in bone metabolic balance due to weight loss cycling. Sexual dimorphism was found between judoka in bone diameters and mass, and significant differences in bone breadths emerged between elite and non-elite judoka. The fall techniques reduced bone impact force and velocity respect 'natural' fall. Further longitudinal, cross-sectional and interventional researches are required. This paper provides useful information on bone for health sport scientists, coaches, and practitioners, stimulating future research lines on judo. In particular, coaches and physical trainers should consider to introduce judo fall techniques in their training plans to prevent fall-related injuries, especially relevant in the older population. Conversely, coaches are urged to carefully control weight cycling dietary habits of their athletes, which can produce serious metabolic responses on bones.

show abstract

Long-term experiment to study the development, interaction, and influencing factors of DEXA parameters

Cited by 4 publications

References 32 publications

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease

Evidence of Wnt/β-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease

Effects of Judo Training on Bones: A Systematic Literature Review

Contact Info

Product

Resources

About