2016
DOI: 10.3892/ijo.2016.3800
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Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features

Abstract: Alcohol consumption is a risk factor for breast cancer. Little is known regarding the mechanism, although it is assumed that acetaldehyde or estrogen mediated pathways play a role. We previously showed that long-term exposure to 2.5 mM ethanol (blood alcohol ~0.012%) of MCF-12A, a human normal epithelial breast cell line, induced epithelial mesenchymal transition (EMT) and oncogenic transformation. In this study, we investigated in the human breast cancer cell line MCF-7, whether a similar exposure to ethanol … Show more

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Cited by 19 publications
(25 citation statements)
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“…Besides, consistent with ceRNA hypothesis, the binding site between miR-1265 and circPICALM is identical to the one between miR-1265 and the STEAP4 3’ UTR. STEAP4 is hypermethylated and downregulated in hepatocellular carcinoma and is elevated in breast cancer cells that obtain oncogenic features after long-term exposure to ethanol [33,45]; however, little is known about its function in BC. TCGA and our data revealed relatively low expression of STEAP4 in BC.…”
Section: Discussionmentioning
confidence: 99%
“…Besides, consistent with ceRNA hypothesis, the binding site between miR-1265 and circPICALM is identical to the one between miR-1265 and the STEAP4 3’ UTR. STEAP4 is hypermethylated and downregulated in hepatocellular carcinoma and is elevated in breast cancer cells that obtain oncogenic features after long-term exposure to ethanol [33,45]; however, little is known about its function in BC. TCGA and our data revealed relatively low expression of STEAP4 in BC.…”
Section: Discussionmentioning
confidence: 99%
“…The expression of STEAP4 is also upregulated in prostate cancer, and its oncogenic role in prostate cancer is proved by several studies [ 14 , 52 , 53 ]. The increased expression of STEAP4 is also found in colorectal cancer [ 54 ], hepatocellular carcinoma [ 55 ], and breast cancer [ 56 ]. Interestingly, Yan et al demonstrated that STEAP4 was decreased in bladder cancer, and the competition between STEAP4 and CircPICALM combined with miR-1265 will affect the EMT process in bladder cancer cells [ 57 ].…”
Section: Discussionmentioning
confidence: 99%
“…Nanog and OCT4 are well-established CSC transcription factors responsible for the stemness network [ 51 ]. Alcohol exposure (25 mM) for 4 weeks increased the expression of Nanog and OCT4 in MCF-7 breast cancer cells [ 52 ]. In a mouse model of liver carcinogenesis, alcohol activated TLR4-Nanog pathway, which was accompanied by the induction CSCs [ 13 ].…”
Section: Cellular and Molecular Mechanisms Underlying Alcohol Stimmentioning
confidence: 99%