Long-term Exposure to Acetaminophen is a Crucial for Activity of Selected Antioxidative Enzymes and Level of Lipid Peroxidation Process in Rat Liver

Polaniak, Renata; Bułdak, Rafał Jakub; Jacheć, W; Helewski, Krzysztof; Wojnicz, Romuald; Birkner, Ewa; Kukla, Michał; Gowarzewski, Marcin; Kubina, Robert; Żwirska-Korczala, K

doi:10.4172/jbb.1000082

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…Diabetes-related factors including steatosis, nonalcoholic fatty liver disease, and cirrhosis may also enhance susceptibility to liver cancer [38][39][40][41]. Various symptoms of liver cancer [42][43][44][45]…”

Section: Liver Cancermentioning

confidence: 99%

A Confront on Cancer allied Diabetic Patients

R¹,

D²,

Nishanth³

2012

J Carcinogene Mutagene

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Insulin resistance, hyperinsulinemia and changes in signaling of different hormones associated with diabetes may affect the risk of breast cancer. We reviewed epidemiologic studies of the association between and risk of different types of cancers and the available evidence on the role of certain mediators of an association between diabetes and cancer. Many evidences supports the modest association between type 2 diabetes and the risk of cancer, the mechanisms underlying an association between diabetes and cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence cancer risk.

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Section: Liver Cancermentioning

confidence: 99%

A Confront on Cancer allied Diabetic Patients

R¹,

D²,

Nishanth³

2012

J Carcinogene Mutagene

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“…Esomeprazole is metabolized extensively in the liver by two cytochrome P450 isoenzymes to metabolites devoid of antisecretory activity. The drug is primarily metabolized by CYP2C19 to hydroxyl and desmethyl metabolites and to a lesser degree by CYP3A4 to sulfone metabolites [49].…”

Section: Oral Transdermal Lipophilic Administrations Of Drugsmentioning

confidence: 99%

Analysis of Pharmacokinetic & Pharmacodynamic Models in Oral and Transdermal Dosage Forms

D¹,

Gajendra²,

Dattatreya³

et al. 2011

JBB

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Bioavailability is a pharmacokinetic term which refers the extent and speed of absorption of the chemicals content in it. After the absorption the drug plays the important role in which the body react i.e. the pharmacodynamics process. Oral drugs, Transdermal drugs, Lipophilic drugs and combined oral drugs all plays the different role after being absorbed and the mode of absorption is also different through various research. The pharmacokinetic parameters (AUC), (C max) and dynamic models express the process of drug ADME reports. Various sample analysis is also being done through various instrumentation and databases. Researches and reports reveal the various side effects of few drugs which are taken orally as well as transdermally and the combine effects are being taken into consideration. The main aim is to analyze the process of drug absorption through various parameters, different instruments and mention the side effects after absorptions.

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“…• The excessive use of paracetamol containing pharmaceuticals has a negative influence on the metabolic functions of the liver [23].…”

Section: Introductionmentioning

confidence: 99%

A New Era of Liver Transplantation – Radioembolization, a Novel Therapy for Hepatocellular Carcinoma

A¹

2011

J Cancer Sci Ther

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Liver failure is one of the major causes of death worldwide and a growing health problem. Now-a-days liver transplantation has been an accepted method to treat many liver disorders. Orthotopic liver transplantation (OLT) is a life-saving procedure for end-stage liver failure. Liver transplantation has some complications involved such as immunosuppression, graft rejection and various side effects. Hepatocellular carcinoma (HCC) is one of the most frequently occurring malignancies and orthotopic liver transplantation is not recommended for patients with Hepatocellular carcinoma. Today, transplantation is entering a new era characterized by a growing interest in novel methods for the treatment of disease that do not necessarily require transferring solid organs between patients. Radioembolization (RE) with radiolabeled microspheres, generally Yttrium-90 microspheres is one such novel method. In this review, a brief emphasis on radioembolization has been described.

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Long-term Exposure to Acetaminophen is a Crucial for Activity of Selected Antioxidative Enzymes and Level of Lipid Peroxidation Process in Rat Liver

Cited by 5 publications

References 31 publications

A Confront on Cancer allied Diabetic Patients

A Confront on Cancer allied Diabetic Patients

Analysis of Pharmacokinetic & Pharmacodynamic Models in Oral and Transdermal Dosage Forms

A New Era of Liver Transplantation – Radioembolization, a Novel Therapy for Hepatocellular Carcinoma

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