Long-term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury

Li, Xueyou; Liu, Yue; Chen, Yuebi; Song, Xiaoqiu; Chen, Xiaotian; Zhang, Ning; Li, Huichen; Guo, Yusong; Wang, Zhongduo; Dong, Zhongdian

doi:10.1016/j.scitotenv.2022.156590

Cited by 34 publications

(7 citation statements)

References 60 publications

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“…Each tank in the BPAF treatment group was exposed to a concentration of 200 µg/L by adding 60 µL of BPAF stock solution. The tanks in the solvent control group were treated with 60 µL of DMSO, resulting in a volume fraction of DMSO at 0.01‰ in each tank, this concentration of DMSO is not expected to have any detrimental effects on the survival and behavior of aquatic organisms [18,22].…”

Section: Experimental Designmentioning

confidence: 99%

Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma)

Li,

Gao,

Liu

et al. 2024

Animals

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In recent years, bisphenol AF (BPAF) in aquatic environments has drawn attention to its ecological risks. This study aims to investigate the toxic effects of BPAF (188.33 μg/L) exposure for 30 days on female marine medaka (Oryzias melastigma). On the 10th and 30th day of exposure, the toxicity was evaluated using histological analysis of the liver and ovaries and the transcription levels of genes related to the antioxidant system, immune system, and hypothalamic-pituitary-gonadal (HPG) axis. Findings revealed that (1) BPAF exposure caused vacuolation, karyopyknosis and karyolysis in the liver of marine medaka, and the toxic impact augmented with duration; (2) exposure to BPAF for 10 days facilitated the growth and maturation of primary ova, and this exposure had a comparatively inhibitory effect after 30 days; (3) exposure to BPAF resulted in a biphasic regulation of the transcriptional abundance of genes involved in antioxidant and inflammatory response (e.g., il-8, cat), with an initial up-regulation followed by down-regulation. Additionally, it disrupted the transcriptional pattern of HPG axis-related genes (e.g., 3βhsd, arα). In conclusion, 188.33 μg/L BPAF can alter the expression levels of functionally related genes, impair the structural integrity of marine organisms, and pose a threat to their overall health.

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Section: Experimental Designmentioning

confidence: 99%

Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma)

Li,

Gao,

Liu

et al. 2024

Animals

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“…BPA has a wide range of uses but is persistent in environmental matrices; hence it can contaminate food chains, groundwater, and oceans. The concentration of BPA in water, wastewater, food, biological liquids, consumer, and personal care products, and semi-solids were 251.00 μg L −1 , 384.80 μg L −1 , 937.49 μg kg −1 , 208.55 μg L −1 , 3590.00 μg g −1 , and 154820.00 μg g −1 , respectively 4 . In surface water and groundwater of Europe and America, the concentrations range from 0.001 to 100 mg m −3 5 .…”

Section: Introductionmentioning

confidence: 97%

“…Also, BPA has endocrinedisrupting effects on aquatic wildlife and humans, with its acute toxicity in mammals valued at 6.50 g kg −1 7,8 . BPA was detected in the urine of approximately 95% of adults in the USA and Asia 4 . And the maximum daily intake in adults was as high as 11.00 μg kg −1 , which was much higher than the average (30.76 ng kg −1 ).…”

Section: Introductionmentioning

confidence: 99%

Degradation of bisphenol A in an oxidation system constructed from Mo2C MXene and peroxymonosulfate

Chen

Gudda

et al. 2022

npj Clean Water

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The etched Mo2C MXene with a layered structure was characterized as an environmentally friendly catalyst in the bisphenol A (BPA) removal by advanced oxidation. 99.75% of BPA was degraded in the oxidation system constructed using Mo2C MXene and peroxymonosulfate (PMS). The Mo2C MXene was recyclable, with a high removal percentage (89.29%) of BPA after even four cycles. The catalysis of Mo2C MXene on PMS was due to the Mo-deficit vacancy defects. The electron paramagnetic resonance technique and density functional theory (DFT)-based density of states calculations verified defect signals. In addition, the defective Mo2C MXene and PMS have strong binding and electron transfer capabilities. The reactive oxygen species (ROS, including O2•−, 1O2, SO4•−, and •OH) produced by Mo2C MXene activates PMS, leading to BPA degradation. The condensed Fukui function predicted the active sites of the BPA molecule and found that the O1, O2, C3, C4, C6, C12, C15, and C16 sites have higher electrophilic reactivity. The C, C–C bonds, or C4/C16 sites in the isopropyl group connecting the two phenolic rings were attacked first, then further transformed BPA into non-toxic or low toxic small molecule degradation products through a series of reactions such as bond-breaking, addition, hydroxylation, and ring-opening. Moreover, the Mo2C MXene/PMS system has strong applicability in actual water bodies. The study provides valuable insights into PMS activation by two-dimensional MXenes to remove toxic organic pollutants in an aqueous matrix.

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“…Now, water environment pollution has become a major social and scientific problem, and biological model monitoring of water environment is of great significance for evaluating the degree of water environment pollution and ecological risks. The small fish zebrafish, Danio rerio , and Japanese medaka, Oryzias latipes , have become the most important freshwater environmental monitoring models (Y. Huang et al, 2015; Min et al, 2003; Thayil et al, 2020), and marine medaka, Oryzias melastigma , is also widely used to monitor the marine environment (Li et al, 2022; Y. Zhang et al, 2020), but there is still a lack of an ideal fish model for detecting estuaries and waters with frequent salinity fluctuations. Salinity is an important parameter affecting the fate of pollutants in the water environment, and the same pollutant may have different toxicity in different salinity environments (Q. S. Huang et al, 2013; You et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…To develop Hainan medaka into a euryhaline water environment monitoring model, it is necessary to have a clearer understanding of the mechanism of its adaptation to salinity. As the main organ of fish to adapt to long‐term salinity changes, liver is also one of the main target organs of environmental pollution (Chen et al, 2022; Li et al, 2022). Mapping the transcriptional map of Hainan medaka liver in response to long‐term changes in salinity will promote its application in the field of water environment monitoring.…”

Section: Introductionmentioning

confidence: 99%

Liver comparative transcriptome analysis reveals the mechanism of the Hainan medaka, Oryzias curvinotus, to adapt to salinity

Dong

Chen

et al. 2022

J World Aquaculture Soc

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To explore the adaptation mechanism of Hainan medaka, Oryzias curvinotus, to salinity, this study performed a histological and RNA-Seq comparative analysis of female medaka liver with different salinities (0, 15 and 30 practical salinity unit [psu]). In the 30 psu group, the volume of hepatocytes was increased and cytoplasmic fat accumulated. A total of 83,758 unigenes were assembled by RNA-Seq, of which 31,147 were annotated. In total, 922 differentially expressed genes (DEGs) were obtained, and the detection results of 24 DEGs by quantitative polymerase chain reaction (qPCR) were consistent with the RNA-Seq data. Gene ontology (GO) enrichment showed that DEGs were mainly involved in biological processes, such as substance synthesis and transport, energy metabolism, signal transduction, and had catalytic activity and binding functions. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that DEGs were significantly enriched in steroid biosynthesis, glycerophospholipid metabolism, peroxisome proliferator-activated receptor signaling pathway, and insulin signaling pathway that regulate lipid metabolism. The results of this study highlight the response of the liver

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Long-term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury

Cited by 34 publications

References 60 publications

Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma)

Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma)

Degradation of bisphenol A in an oxidation system constructed from Mo2C MXene and peroxymonosulfate

Liver comparative transcriptome analysis reveals the mechanism of the Hainan medaka, Oryzias curvinotus, to adapt to salinity

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