Long term exposure to combination paradigm of environmental enrichment, physical exercise and diet reverses the spatial memory deficits and restores hippocampal neurogenesis in ventral subicular lesioned rats

Kapgal, Vijayakumar; Prem, Neethi; Hegde, Preethi; Laxmi, T. Rao; Kutty, Bindu M.

doi:10.1016/j.nlm.2016.01.013

Cited by 24 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in contrast to most experimental models of memory decline induced by various insults such as immobilization stress (Moosavi et al, 2007), ischemia (Yi et al, 2016), β-amyloid (Zhang et al, 2015), and ibotenic acid (Kapgal, Prem, Hegde, Laxmi, & Kutty, 2016; Karthick, Periyasamy, Jayachandran, & Anusuyadevi, 2016) that all were associated with hippocampal damages.…”

Section: Discussioncontrasting

confidence: 60%

Intrahippocampal Insulin Injection Does Not Prevent Against Scopolamine-Induced Spatial Memory Impairment and ERK Alteration

Jahanmahin

Abbasnejad

Haghparast

et al. 2018

Basic Clin. Neurosci. J.

View full text Add to dashboard Cite

Introduction: It is well documented that insulin has neuroprotective and neuromodulator effects and can protect against different models of memory loss. Furthermore, cholinergic activity plays a significant role in memory, and scopolamine-induced memory loss is widely used as an experimental model of dementia. The current study aimed at investigating the possible effects of insulin against scopolamine-induced memory impairment in Wistar rat and its underlying molecular mechanisms. Methods: Accordingly, animals were bilaterally cannulated in CA1, hippocampus. Intrahippocampal administration of insulin 6 MU and 12 MU in CA1 per day was performed during first 6 days after surgery. During next four days, the animal’s spatial learning and memory were assessed in Morris water maze test (three days of learning and one day of retention test). The animals received scopolamine (1 mg/kg) Intraperitoneally (IP) 30 minutes before the onset of behavioral tests in each day. In the last day, the hippocampi were dissected and the levels of MAPK (mitogen-activated protein kinases) and caspase-3 activation were analyzed by Western blot technique. Results: The behavioral results showed that scopolamine impaired spatial learning and memory without activating casapase-3, P38, and JNK, but chronic pretreatment by both doses of insulin was unable to restore this spatial memory impairment. In addition, scopolamine significantly reduced Extracellular signal-Regulated Kinases (ERKs) activity and insulin was unable to restore this reduction. Results revealed that scopolamine-mediated memory loss was not associated with hippocampal damage. Conclusion: Insulin as a neuroprotective agent cannot restore memory when there is no hippocampal damage. In addition, the neuromodulator effect of insulin is not potent enough to overwhelm scopolamine-mediated disruptions of synaptic neurotransmission.

show abstract

Section: Discussioncontrasting

confidence: 60%

Intrahippocampal Insulin Injection Does Not Prevent Against Scopolamine-Induced Spatial Memory Impairment and ERK Alteration

Jahanmahin

Abbasnejad

Haghparast

et al. 2018

Basic Clin. Neurosci. J.

View full text Add to dashboard Cite

show abstract

“…To date, this work has taken place primarily in the hippocampus and has been focused on learning and memory tasks [Denny et al, 2014; but see also Bardy et al, 2010]. These findings build on earlier tests of new neuron function based on examining behavioral effects of reducing [Shors et al, 2001;Winocur et al, 2006;Wojtowicz, 2006;Capilla-Gonzalez et al, 2016] or increasing new neuron numbers [Jurado-Arjona et al, 2016;Kapgal et al, 2016]. Converging evidence from such direct manipulations suggests that new neurons may serve equivalent functions in both the hippocampus and olfactory bulb [Ming and Song, 2011], and two general theses have emerged.…”

Section: Direct Approaches To Understanding New Neuron Function: Renementioning

confidence: 77%

Adult Neurogenesis in the Songbird: Region-Specific Contributions of New Neurons to Behavioral Plasticity and Stability

Pytte

2016

Brain Behav Evol

View full text Add to dashboard Cite

Our understanding of the role of new neurons in learning and encoding new information has been largely based on studies of new neurons in the mammalian dentate gyrus and olfactory bulb - brain regions that may be specialized for learning. Thus the role of new neurons in regions that serve other functions has yet to be fully explored. The song system provides a model for studying new neuron function in brain regions that contribute differently to song learning, song auditory discrimination, and song motor production. These regions subserve learning as well as long-term storage of previously learned information. This review examines the differences between learning-based and activity-based retention of new neurons and explores the potential contributions of new neurons to behavioral stability in the song motor production pathway.

show abstract

“…These findings indicate that RSV reversed the LPS-induced decrease in hippocampal neurogenesis by initiating continuous neurogenesis via symmetrical division. Other contributors to enhanced neurogenesis such as antidepressants, running, and enriched environments may not increase the number of the primary progenitor cells [ 41 - 43 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviorsviaenhanced hippocampal neurogenesis

et al. 2016

View full text Add to dashboard Cite

show abstract

Long term exposure to combination paradigm of environmental enrichment, physical exercise and diet reverses the spatial memory deficits and restores hippocampal neurogenesis in ventral subicular lesioned rats

Cited by 24 publications

References 63 publications

Intrahippocampal Insulin Injection Does Not Prevent Against Scopolamine-Induced Spatial Memory Impairment and ERK Alteration

Intrahippocampal Insulin Injection Does Not Prevent Against Scopolamine-Induced Spatial Memory Impairment and ERK Alteration

Adult Neurogenesis in the Songbird: Region-Specific Contributions of New Neurons to Behavioral Plasticity and Stability

Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviorsviaenhanced hippocampal neurogenesis

Contact Info

Product

Resources

About