Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood

Singh, Anand Kumar; Tiwari, Manindra Nath; Upadhyay, Ghanshyam; Patel, Devendra Kumar; Singh, Dhirendra Kumar; Prakash, Om; Singh, Mahendra Pratap

doi:10.1016/j.neurobiolaging.2010.02.018

Cited by 97 publications

(76 citation statements)

References 39 publications

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“…This might be a consequence of the irreversible dopaminergic neurodegeneration and subsequent DA depletion [Singh et al, 2012]. Consequently, horses with PPID will always present lower DA levels than control horses regardless of any pharmacological intervention.…”

Section: Resultsmentioning

confidence: 99%

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2014

Advances in Animal Biosciences

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Embracing new alternative feed ingredients in feed formulation is an essential component of future sustainable intensification of feed production. Furthermore identification of alternative raw materials is a means of increasing resilience in the supply chain in the face of increased risk due to the pending unreliability of climate. Appreciating the gap between the identification of an alternative raw material and the approval of this material in a commercial raw material data matrix is imperative to a successful adoption of the new product. In this presentation the presumption is made that any new raw material is listed in a national list of permitted raw materials. It is not the intention to review regulatory issues. Unfortunately however it does not follow that a material listed for use in feed in a national list is then used routinely in feed formulation. How a raw material is used can be viewed in terms of either animal factors and/or logistic and commercial factors. The presence of anti-nutritional factors can have a significant impact on how a new raw material is utilised. Independently it can influence the species of animal, the age and stage of growth of an animal and the quantity of material used in the formulation. Furthermore traditional nutrient components such as phytate and fibre are now recognised as antinutritional factors in for example poultry and aqua nutrition respectively. Means of eliminating or negating the impact of anti-nutritional factors is an important aspect of developing an alternative raw material. Least cost ration formulation techniques have been developed to design diets that meet specific requirements from readily available ingredients at the lowest cost. Invariably a new ingredient will only be used in a diet formulation as long as it will reduce the cost of the diet unless the ingredient can provide additional benefits not taken into account in the least cost formulation. This would be the case when a product delivers health benefits in addition to its nutrient specification. A new raw material may satisfy all major nutrient requirements but in addition a number of logistic issues require to be fulfilled. The product must be produced in a quantity to support a supply chain and to be incorporated in one or a number of feed formulations to merit a feed mill allocating space in the mill for storage. Finally the benefit of using the new alternative feed material must create sufficient value to be attractive to the producer of the product, all the active members in the supply chain and finally the livestock producer who will use the product. Biorefineries processing large quantities of grain for biofuels are prime examples of processes capable of producing novel raw materials. Currently the biorefinery process tends to produce a single medium protein, high fibre co-product, distillers dried grains and solubles (DDGS). It is questionable whether this process is viable when large quantities of energy are required to dry the product for feeding to ruminants, the segment of livestock ...

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Section: Resultsmentioning

confidence: 99%

Summaries

2014

Advances in Animal Biosciences

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“…Long-term exposure has been reported to induce dopaminergic neurodegeneration during adulthood in rats [14]. Several studies demonstrated that cypermethrin provoke a range of physiological, biochemical, toxicological, and histological changes in different experimental animals [15,16].…”

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confidence: 99%

Histological study of the effects of cypermethrin on liver and kidney tissues of mice model

Mamun¹,

Illa²,

Haque³

et al. 2014

IOSRJPBS

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“…In addition, this pesticide also inhibits the absorption of calcium by neurons and monoamine oxidase enzymes, responsible for the degradation of some neurotransmitters and indirectly affects the adenosine triphosphatase enzyme, involved in the production of cellular energy, and the transport of metallic atoms and muscle contractions EL-TOUKHY;GIRGIS, 1993;RAO;RAO, 1993). Chronic exposure to CP resulted in decreased dopamine levels followed by dopaminergic neurodegeneration (SINGH et al, 2012).…”

Section: Absorption Metabolism and Excretionmentioning

confidence: 99%

Cypermethrin exposure and effects on the reproductive male system: a literature review

2017

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The use of pesticides has become a major problem of public and environmental health in the world and especially in Brazil, which consumes tons of these compounds every year since the 50s. Among the pesticides, cypermethrin is an admittedly widely used synthetic pyrethroid due to its broad spectrum of action, resulting in its massive use in the agricultural sector. Epidemiological data show a considerable increase in the incidence of diseases in the male reproductive tract among them, the decline of sperm quality in various regions of the world, with consequent increase in demand for assisted reproduction services and increased incidences of cryptorchidism, hypospadias and testicular tumors. In recent years, researchers have shown that some pyrethroid compounds are capable of interfering with the endocrine system of animal species, including human being and therefore can be considered as endocrine disrupters. They can result in a deviation from normal homeostatic control or reproduction by interfering with the synthesis, secretion, transport, binding, action or elimination of natural hormones. It has been reported that endocrine disruptors may be responsible for the decline in sperm density and increase in hypospadias, cryptorchidism and testicular Revinter, v. 10, n. 03, p. 18-38, out. 2017. P á g i n a19 | 38 cancer in humans. In this sense, experimental studies have shown that cypermethrin acts indirectly on male gametogenesis, interfering with the synthesis of testosterone.Other disorders induced by cypermethrin are also reported, as structural changes of the seminiferous tubules, morphological changes in germ cells and sperm as well as a reduction in their count in semen. This paper aims to demonstrate aspects of endocrine disruption in the male reproductive system related to cypermethrin exposure, using data from animal studies (in vivo) and biological samples of human beings (in vitro). células germinativas e espermatozoides, bem como uma redução na sua contagem no sêmen. Este trabalho tem como objetivo demonstrar aspectos da desregulação endócrina no sistema reprodutor masculino relacionados à exposição à cipermetrina, utilizando dados de estudos animais (in vivo) e amostras biológicas de seres humanos (in vitro). Palavras

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Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood

Cited by 97 publications

References 39 publications

Summaries

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Histological study of the effects of cypermethrin on liver and kidney tissues of mice model

Cypermethrin exposure and effects on the reproductive male system: a literature review

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