Long-term exposure to fine particulate matter modifies the association between physical activity and the risk of hypertension

Zhao, Yufan; Guo, Qian; Zhao, Jiahao; Bian, Mengyao; Qian, Liqianxin; Wang, Qirong; Duan, Xiaoli

doi:10.1007/s11356-023-25256-6

Cited by 1 publication

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A meta-analysis of 15 randomized controlled trials (RCT) studies indicated that PA significantly reduced 24-h, day-time, and night-time blood pressure of hypertension patients ( 57 ). The benefits of PA on blood pressure and hypertension risk might be explained by reducing cardiac output, plasma norepinephrine levels, sympathetic activity, and total peripheral resistance ( 16 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…Despite no similar study has been published previously, our findings could be supported by the following aspects. Firstly, several studies investigated the modification effect of air pollution in the associations of PA with blood pressure and hypertension risk and indicated long-term exposure to air pollution could attenuate the beneficial effects of PA on blood pressure and hypertension risk ( 21 , 22 ). Secondly, several studies reported that PA could attenuate the adverse effects of air pollution on chronic diseases, including metabolic syndrome ( 32 , 58 ), diabetes ( 59 ), CVDs ( 60 ) and cognitive function ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…It cannot be ignored that PA also increases the risk of exposure to higher air pollution and leads to higher inhaled air pollutants, which might reduce or even negate the benefits of PA ( 21 ). Several studies have examined the joint effects of air pollution and PA on blood pressure ( 21 , 22 ). For example, a nationwide cohort study of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) examined the modification effect of long-term exposure to PM 2.5 in the associations between PA and hypertension incidence and indicated that PA was associated with decreased hypertension only among participants with low PM 2.5 exposure ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

“…For example, a nationwide cohort study of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) examined the modification effect of long-term exposure to PM 2.5 in the associations between PA and hypertension incidence and indicated that PA was associated with decreased hypertension only among participants with low PM 2.5 exposure ( 22 ). As for blood pressure, a cohort study of the China Health and Retirement Longitudinal Study (CHARLS) found that exposure to higher PM 2.5 could attenuate the beneficial effects of PA on blood pressure ( 21 ). However, those two studies only examined the modification effects of PA in the associations of air pollution with hypertension and/or blood pressure, the health effects of air pollution on blood pressure and hypertension risk among different PA groups have still not been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Associations of long-term exposure to air pollution, physical activity with blood pressure and prevalence of hypertension: the China Health and Retirement Longitudinal Study

Zhang

Xin³

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundLong-term exposure to air pollution and physical activity (PA) are linked to blood pressure and hypertension. However, the joint effect of air pollution and PA on blood pressure and hypertension are still unknown in Chinese middle-aged and older adults.MethodsA total of 14,622 middle-aged and older adults from the China Health and Retirement Longitudinal Study wave 3 were included in this study. Ambient air pollution [particulate matter with diameter ≤ 2.5 μm (PM2.5), or ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbonic oxide (CO)] were estimated using satellite-based spatiotemporal models. PA was investigated using International Physical Activity Questionnaire. Generalized linear models were used to examine the associations of air pollution, PA score with blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP)], and the prevalence of hypertension. Subgroup analysis was conducted to investigate the effects of air pollution on blood pressure and the prevalence of hypertension in different PA groups.ResultsThe results showed that for each inter-quartile range (IQR) increase in PM2.5 (25.45 μg/m3), PM10 (40.56 μg/m3), SO2 (18.61 μg/m3), NO2 (11.16 μg/m3), CO (0.42 mg/m3) and PA score (161.3 MET/h-week), the adjusted odd ratio (OR) of hypertension was 1.207 (95% confidence interval (CI): 1.137, 1.281), 1.189 (95%CI: 1.122, 1.260), 1.186 (95%CI: 1.112, 1.266), 1.186 (95%CI: 1.116, 1.260), 1.288 (95%CI: 1.223, 1.357), 0.948 (95%CI: 0.899, 0.999), respectively. Long-term exposure to PM2.5, PM10, SO2, NO2, and CO was associated with increased SBP, DBP, and MAP levels. For example, each IQR increase in PM2.5 was associated with 1.20 mmHg (95%CI: 0.69, 1.72) change in SBP, 0.66 mmHg (95%CI: 0.36, 0.97) change in DBP, and 0.84 mmHg (95%CI: 0.49, 1.19) change in MAP levels, respectively. Each IQR increase in PA score was associated with −0.56 mmHg (95%CI: −1.03, −0.09) change in SBP, −0.32 mmHg (95%CI: −0.59, −0.05) change in DBP, and −0.33 mmHg (95%CI: −0.64, −0.02) change in MAP levels, respectively. Subgroup analysis found that the estimated effects in the sufficient PA group were lower than that in the insufficient PA group.ConclusionLong-term exposure to air pollutants is associated with increased blood pressure and hypertension risk, while high-level PA is associated with decreased blood pressure and hypertension risk. Strengthening PA might attenuate the adverse effects of air pollution on blood pressure and hypertension risk.

show abstract

Section: Discussionmentioning

confidence: 99%