Long-term exposure to fine particulate matter and osteoporotic fracture: A case–control study in Taiwan

Chiu, Yung-Cheng; Lin, Yu-Ting; Hsia, Ying-Fang; Jung, Chau-Ren; Lo, Yu Chieh; Chen, Tung-Ming; Chan, Ju-Chu; Wang, Yu-Chih; Kuo, Cheng-Tzu; Hwang, Bing‐Fang

doi:10.1016/j.envres.2021.110888

Cited by 15 publications

(11 citation statements)

References 40 publications

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“…Alver et al applied a time-independent variable for air pollution exposure (PM, NO 2 ) from 1992 to 2001 in their cohort study for self-reported forearm fracture [ 16 ]. Chiu et al used average PM 2.5 concentration for the one year before the index date in their case-control study of osteoporotic fracture [ 1 ]. Prada et al assessed the association of one-year PM 2.5 average and the count of hospital admissions from osteoporotic fracture for each year in 2003–2010 using generalized linear mixed models [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Higher risks of osteoporosis in female adults than male adults have been suggested in previous studies [ 41 ]. Estrogen deficiency in postmenopausal females is a known risk factor for osteoporosis and osteoporotic bone fracture [ 1 ]. We also found significant associations between SO 2 and osteoporosis-related fracture in the younger age group (50–69 years), high income persons, and persons with higher frequency of exercise.…”

Section: Discussionmentioning

confidence: 99%

“…We identified osteoporosis-related bone fracture using operational ascertainment based on procedure codes as well as disease codes, (ICD) although we did not have information of osteoporosis based on BMD or laboratory examinations. Previous studies mainly identified osteoporotic fracture using ICD codes [ 14 , 17 , 18 ], but one study identified patients using ICD codes and surgical codes [ 1 ]. Moreover, the cohort in this study is a sample representing a large portion of the entire population.…”

Section: Discussionmentioning

confidence: 99%

“…One of the major public health concerns of aging is bone-related health. The global prevalence of osteoporosis is more than 200 million people, which constitutes 1% of all disability and causes 8.9 million osteoporosis-related fractures every year globally [ 1 ]. Osteoporosis can be associated with bone fracture, which can lead to disability or mortality [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea

Heo

Kim

et al. 2022

IJERPH

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Bone health is a major concern for aging populations globally. Osteoporosis and bone mineral density are associated with air pollution, but less is known about the impacts of air pollution on osteoporotic fracture. We aimed to assess the associations between long-term air pollution exposure and risk of osteoporotic fracture in seven large Korean cities. We used Cox proportional hazard models to estimate hazard rations (HRs) of time-varying moving window of past exposures of particulate matter (PM10), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and ozone (O3) for osteoporotic fracture in Korean adults (age ≥50 y) in the National Health Insurance Service-National Sample Cohort data, followed 2002 to 2015. HRs were calculated for an interquartile range (IQR) increase. Comorbidity and prescription associated with osteoporosis, age, sex, body mass index, health behaviors, and income were adjusted in the models. Effect modification by age, sex, exercise, and income was examined. We assessed 56,467 participants over 535,481 person-years of follow up. Linear and positive exposure-response associations were found for SO2, while PM10 and NO2 showed nonlinear associations. SO2 was associated with osteoporosis-related fracture with marginal significance (HR for an IQR [2 ppb] increase = 1.04, 95% CI: 1.00, 1.09). The SO2 HR estimates were robust in analyses applying various moving windows of exposure (from one to three years of past exposure) and two-pollutant models. The central HR estimate of O3 implied positive associations but was not significant (HR for 0.007 ppm increase = 1.01, 95% CI: 0.97, 1.06). PM10, CO, and NO2 did not show associations. Vulnerable groups by sex, age, exercise, and income varied across air pollutants and there was no evidence of effect modifications. Long-term exposure to SO2, but not PM10, CO, NO2 and O3, was associated with increased osteoporotic fracture risks in Korean adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea

Heo

Kim

et al. 2022

IJERPH

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“…Growing evidence pointed out that genetic, lifestyle, and environmental factors play roles in osteoporotic fracture to some extent (11)(12)(13)(14). Fraenkel et al found the daily rates of osteoporotic hip fractures in winter (1.1 cases per day) were significantly higher than summer (0.79 cases per day), autumn (0.90 cases per day) and spring (0.91 cases per day) (15).…”

Section: Introductionmentioning

confidence: 99%

Is Cold Apparent Temperature Associated With the Hospitalizations for Osteoporotic Fractures in the Central Areas of Wuhan? A Time-Series Study

Zhang

Zhou

et al. 2022

Front. Public Health

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Osteoporosis is alarming problem due to aggravation of global aging, especially in China. Osteoporotic fracture (OF) is one of the most severe consequents of osteoporosis. Many previous studies found that environmental factors had adverse effects on human health. Cold temperature was associated with OF and bone metabolism in prior observational and experimental researches. However, few studies had been conducted on the acute effect of low temperature and OF. Data on daily meteorological factors and hospitalizations for OF were collected from Wuhan, China, between January 1, 2017 to December 24, 2019. Apparent temperature (AT), comprehensively considered a variety of environmental factors, was calculated by ambient temperature, relative humidity and wind speed. A generalized linear regression model combined with distributed lag non-linear regression model (DLNM) with quasi-Poisson link was used to explore the association between AT and the number of hospitalizations for OF. Subgroup analyses stratified by gender, age and the history of fracture were applied for detecting susceptible people. The exposure-response curve of AT and OF were generally U-shaped with lowest point at 25.8°C. The significant relationship of AT-OF existed only in cold effect (−2.0 vs. 25.8°C) while not in warm effect (37.0 vs. 25.8°C). Statistically significant risks of OF for cold effects were only found in females [RR = 1.12 (95%CI: 1.02, 1.24) at lag 2 day], aged <75 years old [RR = 1.18 (95%CI: 1.04, 1.33) and 1.17 (95%CI: 1.04, 1.33) at lag 2 and 3 days, respectively] and people with history of fracture [RR = 1.39 (95%CI: 1.02, 1.90) and 1.27 (95%CI: 1.05, 1.53) at lag 1 and 2 days, respectively]. The significant associations of AT on OF were only found in cold effect. The females, people aged <75 years and people with history of fracture possibly appeared to be more vulnerable. Public health departments should pay attention to the negative effect of cold AT and take measures in time.

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Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

Zhang

et al. 2023

Arch Osteoporos

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Long-term exposure to fine particulate matter and osteoporotic fracture: A case–control study in Taiwan

Cited by 15 publications

References 40 publications

Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea

Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea

Is Cold Apparent Temperature Associated With the Hospitalizations for Osteoporotic Fractures in the Central Areas of Wuhan? A Time-Series Study

Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

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