Long-Term Exposure to Traffic Emissions and Fine Particulate Matter and Lung Function Decline in the Framingham Heart Study

Rice, Mary B.; Ljungman, Petter; Wilker, Elissa H.; Dorans, Kirsten; Gold, Diane R.; Schwartz, Joel; Koutrakis, Petros; Washko, George R.; O’Connor, George T.; Mittleman, Murray A.

doi:10.1164/rccm.201410-1875oc

Cited by 248 publications

(177 citation statements)

References 37 publications

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“…Although some studies have also found proportional associations of air pollution with FEV 1 and FVC in a restrictive pattern (8,13), other studies have found a largermagnitude association with FEV 1 than FVC, suggesting an obstructive effect involving the larger airways (9,30,31). Two recent studies that examined long-term PM 2.5 and BC exposure in the Boston area using the same models as the present study found restrictive patterns of effects on adult lung function and lung function decline (21,32). One possible explanation for the restrictive pattern of associations we found is that air pollution may slow lung growth in children (and accelerate lung function decline in adults).…”

Section: Discussionsupporting

confidence: 43%

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

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121

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Rationale: Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s.Objectives: To assess traffic-related pollution exposure and childhood lung function.Methods: We geocoded addresses for 614 mother-child pairs enrolled during pregnancy in the Boston area 1999-2002 and followed them until a mid-childhood visit (median age, 7.7). We calculated the proximity of the home to the nearest major roadway. We estimated first year of life, lifetime, and prior-year exposure to particulate matter with a diameter smaller than 2.5 mm (PM 2.5 ) by a hybrid model using satellite-derived aerosol optical depth, and to black carbon (BC) by a land-use regression model. Measurements and Main Results:Residential proximity to roadway and prior-year and lifetime PM 2.5 and BC exposure were all associated with lower FVC. Associations with FEV 1 were also negative and proportionally similar. Pollution exposures were not associated with the FEV 1 /FVC ratio or bronchodilator response. Compared with distances greater than or equal to 400 m, living less than 100 m from a major roadway was associated with lower FVC (298.6 ml; 2176.3 to 221.0). Each 2 mg/m 3 increment in prior-year PM 2.5 was associated with lower FVC (221.8 ml; 243.9 to 0.2) and higher odds of FEV 1 less than 80% predicted (1.41; 1.03-1.93). Each 0.2 mg/m 3 increment in prior-year BC was associated with a 38.9 ml (270.4 to 27.3) lower FVC.Conclusions: Estimates of long-term exposure to ambient pollution, including proximity to major roadway, PM 2.5 , and BC (a traffic-related PM 2.5 constituent), were associated with lower lung function in this Boston-area cohort of children with relatively low pollution exposures.

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Section: Discussionsupporting

confidence: 43%

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

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121

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“…Environmental and occupational exposures are linked to the development of COPD in the general population [67][68][69][70]. In homozygous ZZ individuals, exposure to dust, gas and fumes leads to a greater decline in lung function, even in nonsmoking ZZ subjects, particularly after the age of 50 years [71,72].…”

Section: Effects Of Environmental and Occupational Exposuresmentioning

confidence: 99%

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Ashry

Strange

2017

Eur Respir Rev

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Since the discovery of severe alpha-1 antitrypsin deficiency as a genetic risk factor for emphysema, there has been ongoing debate over whether individuals with intermediate deficiency with one protease inhibitor Z allele (PiMZ, or MZ) are at some risk for emphysema. This is important, because MZ individuals comprise 2-5% of the general population. In this review we summarise the evidence about the risks of the MZ population to develop emphysema or asthma. We discuss the different study designs that have tried to answer this question. The risk of emphysema is more pronounced in case-control than in population-based studies, perhaps due to inadequate power. Carefully designed family studies show an increased risk of emphysema in MZ smokers. This is supported by the rapid decline in lung function of MZ individuals when compared to the general population after massive environmental exposures. The risk of asthma in MZ subjects is less studied, and more literature is needed before firm conclusions can be made. Augmentation therapy in MZ individuals is not supported by any objective studies. MZ smokers are at increased risk for emphysema that is more pronounced when other environmental challenges are present.

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“…Длительное воздействие РМ2,5 способствует возник-новению и обострению ХОБЛ [31,32] и снижению пока-зателей функции внешнего дыхания [33][34][35]. С увеличе-нием уровня PM в атмосфере было отмечено увеличение распространенности и симптомов бронхиальной астмы (БА) [32,36].…”

Section: долговременное воздействие рмunclassified

The Role of Air Pollution by the Particulate Matter in Pathogenesis of the Chronic Noninfectious Diseases

Колпакова¹,

Sharipov²,

Kolpakov³

2018

Sib. med. ž. (Tomsk)

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В обзоре даны современные представления о связи загрязнения атмосферного воздуха взвешенными частицами с заболеваемостью и смертностью от хронических неинфекционных заболеваний. Рассмотрены результаты кра-тковременного и долговременного влияния взвешенных частиц на патогенез хронических неинфекционных за-болеваний в зависимости от их размера, происхождения, химического состава, концентрации в воздухе. Ключевые слова: загрязнение воздуха, взвешенные частицы, патогенез, хронические неинфекционные заболевания Конфликт интересов: авторы заявляют об отсутствии конфликта интересов Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах Для цитирования: Колпакова А. Ф., Шарипов Р. Н., Колпаков Ф. А. О роли загрязнения атмосферного воздуха взве-шенными частицами в патогенезе хронических неинфекционных заболеваний. Сибирский медицинский журнал. 2018; 33(1): 7-13. DOI: 10.29001/2073DOI: 10.29001/ -8552-2018 The article presents modern outlooks of relationship between air pollution by particulate matter (PM) and human morbidity and mortality from chronic noninfectious diseases. The results of short-and long-term influence of PM on the pathogenesis of chronic noninfectious diseases depending on size, origin, chemical composition, and concentration in the air are discussed.

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Long-Term Exposure to Traffic Emissions and Fine Particulate Matter and Lung Function Decline in the Framingham Heart Study

Cited by 248 publications

References 37 publications

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Lifetime Exposure to Ambient Pollution and Lung Function in Children

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

The Role of Air Pollution by the Particulate Matter in Pathogenesis of the Chronic Noninfectious Diseases

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