2018
DOI: 10.1016/j.envint.2017.12.031
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Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN)

Abstract: At common levels in Europe, long-term residential total THMs were not related to female breast cancer. A moderate association with chloroform was suggested at the highest exposure category. This large epidemiological study with extensive exposure assessment overcomes several limitations of previous studies but further studies are needed to confirm these results.

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Cited by 23 publications
(13 citation statements)
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“…Other sources of exposure to dioxin are backyard waste incineration, cooking with fires generated by wood and coal, vehicular exhausts and tobacco smoke. Plastics and constituents, Water pollution, Disinfection byproducts in drinking water (DBP): Trihalogenated methanes [88][89][90][91][92][93][94][95][96][97][98][99][100][101] Polyvinyl Chloride (PVC), a type of heat-resistant polymer, is used for packaging fruit juice, and cooking oil. It is considered highly toxic due to the presence of chemical constituents like heavy metals, dioxins, BPA, and phthalates.…”
Section: Butadiene Ethylene Oxidementioning
confidence: 99%
“…Other sources of exposure to dioxin are backyard waste incineration, cooking with fires generated by wood and coal, vehicular exhausts and tobacco smoke. Plastics and constituents, Water pollution, Disinfection byproducts in drinking water (DBP): Trihalogenated methanes [88][89][90][91][92][93][94][95][96][97][98][99][100][101] Polyvinyl Chloride (PVC), a type of heat-resistant polymer, is used for packaging fruit juice, and cooking oil. It is considered highly toxic due to the presence of chemical constituents like heavy metals, dioxins, BPA, and phthalates.…”
Section: Butadiene Ethylene Oxidementioning
confidence: 99%
“…Os THM, por sua vez, constituem a classe mais comum e dominante de DBP, contribuindo com 10-20% na composição da água clorada 6 . Por sua alta prevalência e concentração, são os compostos mais estudados 7 .…”
Section: Introductionunclassified
“…Os relatos na literatura estabelecem uma relação íntima entre a exposição aos THM, mais especificamente a crônica, e seus efeitos adversos, uma vez que, após a absorção, esses elementos tendem à bioacumulação no organismo, causando citotoxicidade, genotoxicidade e mutagenicidade, resultando assim em efeitos cancerígenos. Por isso, são frequentemente relatados na literatura como potenciais carcinogênicos, possuindo uma estreita relação com o câncer de bexiga e eventualmente, mas com uma prevalência menor, com câncer de cólon e de reto 7,8 .…”
Section: Introductionunclassified
“…Durante 1989 se examinaron las concentraciones de contaminantes en 35 plantas de tratamiento, y se encontró que los THMs eran los subproductos de la desinfección presentes en mayor cantidad (Ioannou et al, 2016), los cuatro THMs más comunes son el cloroformo, dibromoclorometano, diclorobromometano y bromoformo. De acuerdo a la Agencia Internacional de Investigación en Cáncer (IARC, por sus siglas en inglés) los THMs son agentes cancerígenos del grupo 2B (IARC, 1999); el cloroformo es el THM más común en los sistemas de distribución que usan agua superficial, no se cumple esto en sistemas que tratan agua subterránea, en la que el bromoformo es el más abundante, el dibromoclorometano es el que produce un mayor riesgo a padecer cáncer, seguido por el bromoformo, cloroformo y diclorobromometano (Font-Ribera et al, 2018). Se han realizado estudios que sugieren una conexión entre los THMs y cáncer de vejiga, y posiblemente cáncer de colon y recto (Min y Min, 2016), otros estudios han asociado a los THMs con problemas reproductivos, incluyendo el aumento al riesgo de abortos, tal es el caso de un estudio en California (EE.UU.)…”
Section: Introductionunclassified