Long-term fate of neural precursor cells following transplantation into developing and adult CNS

Lepore, Angelo C.; Neuhuber, Birgit; Connors, Theresa; Han, Steve S.W.; Liu, Y.; Daniels, MP; Rao, Mahendra S.; Fischer, Itzhak

doi:10.1016/j.neuroscience.2005.12.067

Cited by 75 publications

(39 citation statements)

References 45 publications

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“…These cells underwent the process of differentiation into myelin-making cells and engaged in subsequent remyelination, which led to a decrease in net myelin and axonal loss (14,15). Transplanted aNSCs survive in the CNS for up to 15 months, without any sign of deleterious outcomes, such as tumor formation, adverse immune responses, or inappropriate anatomical accumulation (34).…”

Section: Discussionmentioning

confidence: 99%

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Yang¹,

Jiang²,

Fitzgerald³

et al. 2009

J. Clin. Invest.

187

179

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Section: Discussionmentioning

confidence: 99%

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Yang¹,

Jiang²,

Fitzgerald³

et al. 2009

J. Clin. Invest.

187

179

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“…It has been shown that when differentiated cells are transplanted into injured spinal cord, the grafted cell processes always made synaptic connections with the processes of endogenous neurons. 22 Other short-term studies have noted neuronal differentiation, synapse formation and electrophysiological connectivity after transplantation of neural precursor cells. 23 Beside these synaptic connections, secretion of neurotrophic factors, including transforming growth factor-a and brain-derived neurotrophic factor, from transplanted differentiated cells can contribute to functional recovery.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of a combination of autologous neural differentiated and undifferentiated mesenchymal stem cells into injured spinal cord of rats

et al. 2009

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Study design: The use of stem cells for functional recovery after spinal cord injury. Objective: The aim of this study was to evaluate the effects of a combination of autologous undifferentiated and neural-induced bone marrow mesenchymal stem cells (MSCs) on behavioral improvement in rats after inducing spinal cord injury and comparing with transplantation of undifferentiated and neural-induced MSCs alone. Setting: The study was conducted at the department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Methods: The spinal cord was injured by contusion using a Fogarty embolectomy catheter at the T8-T9 level of the spinal cord, and autologous MSCs were transplanted into the center of the developing lesion cavity, 3 mm cranial and 3 mm caudal to the cavity, at 7 days after induction of spinal cord compression injury. Results: At 5 weeks after transplantation, the presence of transplanted cells was detected in the spinal cord parenchyma using immunohistochemistry analysis. In all treatment groups (differentiated, undifferentiated and mix), there was less cavitation than lesion sites in the control group. The BassoBeattie-Bresnahan (BBB) score was significantly higher in rats transplanted with a combination of cells and in rats transplanted with neural-induced MSCs alone than in undifferentiated and control rats. Conclusion: Pre-differentiation of MSCs to neuron-like cells has a very important role in achieving the best results for functional improvement.

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“…Other studies have transplanted neural stem and progenitor cells into areas of the adult brain undergoing active neurogenesis such as the hippocampus and sub ventricular zone, and shown that the cells can identify local cues and follow endogenous patterns of proliferation and differentiation into neurons (8,11,25). In some cases these cells have been shown to survive for extended periods of time and integrate well into the host brain tissue (17). Thus, the environment seems to play a crucial role in the survival and differentiation of both primary fetal tissue and stem or progenitor cell transplants which have the potential to form long term grafts within the brain.…”

Section: Introductionmentioning

confidence: 99%

Lesion-Induced Increase in Survival and Migration of Human Neural Progenitor Cells Releasing GDNF

et al. 2008

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The use of human neural progenitor cells (hNPC) has been proposed to provide neuronal replacement or astrocytes delivering growth factors for brain disorders such as Parkinson's and Huntington's disease. Success in such studies likely requires migration from the site of transplantation and integration into host tissue in the face of ongoing damage. In the current study, hNPC modified to release glial cell line derived neurotrophic factor (hNPC GDNF ) were transplanted into either intact or lesioned animals. GDNF release itself had no effect on the survival, migration or differentiation of the cells. The most robust migration and survival was found using a direct lesion of striatum (Huntington's model) with indirect lesions of the dopamine system (Parkinson's model) or intact animals showing successively less migration and survival. No lesion affected differentiation patterns. We conclude that the type of brain injury dictates migration and integration of hNPC which has important consequences when considering transplantation of these cells as a therapy for neurodegenerative diseases.

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Long-term fate of neural precursor cells following transplantation into developing and adult CNS

Cited by 75 publications

References 45 publications

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Transplantation of a combination of autologous neural differentiated and undifferentiated mesenchymal stem cells into injured spinal cord of rats

Lesion-Induced Increase in Survival and Migration of Human Neural Progenitor Cells Releasing GDNF

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