Long-term fate of the internal mammary artery and saphenous vein grafts

Singh, Richa; Sosa, Julio A.; Green, George E.

doi:10.1016/s0022-5223(19)39147-0

Cited by 162 publications

(20 citation statements)

References 14 publications

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“…The ITA graft has the best long-term patency rates of all conduits currently used for CABG, because of its resistance to atherosclerosis. 8,9 This may be due to some morphologic differences, such as blood supply from the vasa vasorum, the components of the medial layer, and innervation. Biochemical factors may also differ, such as the supply of nutrients to the wall of the conduit, effects of produced vasoactive substances, and the removal of metabolites.…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis of Radial and Internal Thoracic Arteries Used in Coronary Bypass: Atherosclerosis in Arterial Grafts

Özkan¹,

Akay²,

Gültekin³

et al. 2007

J Cardiac Surgery

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Section: Discussionmentioning

confidence: 99%

Atherosclerosis of Radial and Internal Thoracic Arteries Used in Coronary Bypass: Atherosclerosis in Arterial Grafts

Özkan¹,

Akay²,

Gültekin³

et al. 2007

J Cardiac Surgery

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“…The internal mammary artery (IMA) has become a artery bypass operations in an attempt to inhibit postpreferred conduit for coronary bypass because of its operative IMA spasm. It has been suggested that superior long-term results [1][2][3][4][5][6]. However, peri-the effect of calcium antagonists on a-adrenoceptoroperative IMA spasm has been a recognized complica-mediated contraction depends on 1) the subtype of ation [7,8].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of calcium antagonists on alpha‐adrenoceptor‐ mediated contraction in the human internal mammary artery.

Acuff

Ryan

et al. 1994

Brit J Clinical Pharma

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1. The internal mammary artery has become a preferred coronary bypass graft. Sympathomimetic amines are spasmogens for vasospasm and calcium antagonists are frequently administered drugs perioperatively. The effect of calcium antagonists on alpha‐adrenoceptor‐mediated contraction depends on the subtype of alpha‐adrenoceptor and the type of origin of vascular smooth muscle. This study was designed to investigate the effect of calcium antagonists on alpha‐adrenoceptor‐ mediated contraction in the IMA. 2. Human IMA segments taken from 22 patients undergoing IMA—coronary artery bypass grafting were mounted in an organ bath under the physiological pressure determined from their own length‐tension curves. 3. Three ring segments were allocated into three groups. One served as a control and the others were treated with clinically related concentrations of nifedipine (20 or 200 nM) for 25 min before concentration‐contraction curves to alpha 1‐adrenoceptor agonist methoxamine (MO) or full alpha‐adrenoceptor agonist noradrenaline (NA) were established. 4. In separate experiments, the concentration‐relaxation curves to nifedipine were established in the IMA rings precontracted with MO (30 microM) or NA (10 microM). Glyceryl trinitrate (GTN, 3 microM) was added to further relax the vessels. 5. Pretreatment with nifedipine (200 nM) only slightly inhibited the MO‐ (1.74 +/‐ 0.32 vs 2.88 +/‐ 0.56 g) or NA‐ (2.43 +/‐ 0.66 vs 3.60 +/‐ 0.82 g) induced contraction without statistical significance (P > 0.05). 6. On the other hand, nifedipine only caused 34.49% relaxation in the MO‐precontracted and 24.39% relaxation in the NA‐precontracted IMAs. In contrast, GTN caused 76.16% (against MO, P < 0.05) or 92.22% (against NA, P < 0.0001) relaxation.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…A prospective study with routine angiography at specified intervals would be the best way to determine graft patency. Although in some prospective studies high proportions of patients have undergone early angiography, by 5 years patient dropout due to death, reoperation, and refusal to participate alter the characteristics of the remaining population in nonrandom ways [17][18][19][20].…”

Section: Limitations and Methodological Considerationsmentioning

confidence: 99%

Natural History of Moderate Coronary Artery Stenosis After Surgical Revascularization

Raza

Blackstone

Houghtaling

et al. 2018

The Annals of Thoracic Surgery

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Long-term fate of the internal mammary artery and saphenous vein grafts

Cited by 162 publications

References 14 publications

Atherosclerosis of Radial and Internal Thoracic Arteries Used in Coronary Bypass: Atherosclerosis in Arterial Grafts

Atherosclerosis of Radial and Internal Thoracic Arteries Used in Coronary Bypass: Atherosclerosis in Arterial Grafts

Inhibitory effects of calcium antagonists on alpha‐adrenoceptor‐ mediated contraction in the human internal mammary artery.

Natural History of Moderate Coronary Artery Stenosis After Surgical Revascularization

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