Long term follow-up after a single intravitreal ranibizumab injection for choroidal neovascularisation secondary to optic nerve head drusen in a 5-year-old child

Baillif, S.; Nguyen, Elisabeth; Hayek, Anne Colleville-El; Bétis, F.

doi:10.1007/s00417-012-2180-8

Cited by 19 publications

(6 citation statements)

References 6 publications

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“…73 In some cases it can extend into the macula and fovea, causing vision loss via submacular fluid and/or hemorrhage. 9; 99; 178; 184 …”

Section: Complicationsmentioning

confidence: 99%

“…Successful treatment of optic disc drusen with CNVM has been reported with surgery, 123; 200 laser photocoagulation, 38 photodynamic therapy, 29; 193 and more recently intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents. 2; 9; 37; 69; 84; 99; 175 Both bevacizumab and ranibizumab have been used successfully in children with CNVM secondary to optic disc drusen as young as five years of age. 9; 99 Although some clinicians use anti-VEGF agents to treat infants with retinopathy of prematurity, concerns still exist regarding the safety of these drugs, particularly bevacizumab, in the pediatric population.…”

Section: Treatmentmentioning

confidence: 99%

“…2; 9; 37; 69; 84; 99; 175 Both bevacizumab and ranibizumab have been used successfully in children with CNVM secondary to optic disc drusen as young as five years of age. 9; 99 Although some clinicians use anti-VEGF agents to treat infants with retinopathy of prematurity, concerns still exist regarding the safety of these drugs, particularly bevacizumab, in the pediatric population. 99 The long-term systemic effects on developing organs have yet to be determined, and they should be used with caution in children.…”

Section: Treatmentmentioning

confidence: 99%

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Optic disk drusen in children

Chang

Pineles

2016

Survey of Ophthalmology

112

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Optic disc drusen occur in 0.4% of children and consist of acellular intracellular and extracellular deposits that often become calcified over time. They are typically buried early in life and generally become superficial, and therefore visible, later in childhood, at the average age of 12 years. Their main clinical significance lies in the ability of optic disc drusen, particularly when buried, to simulate true optic disc edema. Misdiagnosing drusen as true disc edema may lead to an invasive and unnecessary workup for elevated intracranial pressure. Ancillary testing, including ultrasonography, fluorescein angiography, fundus autofluorescence, and optical coherence tomography, may aid in the correct diagnosis of optic disc drusen. Complications of optic disc drusen in children include visual field defects, hemorrhages, choroidal neovascular membrane, non-arteritic anterior ischemic optic neuropathy, and retinal vascular occlusions. Treatment options for these complications include ocular hypotensive agents for visual field defects and intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents for choroidal neovascular membranes. In most cases, however, children with optic disc drusen can be managed by observation with serial examinations and visual field testing, once true optic disc edema has been excluded.

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“…73 In some cases it can extend into the macula and fovea, causing vision loss via submacular fluid and/or hemorrhage. 9; 99; 178; 184 …”

Section: Complicationsmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Optic disk drusen in children

Chang

Pineles

2016

Survey of Ophthalmology

112

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“…They used a combination of focal laser photocoagulation and intravitreal bevacizumab 8. Baillif et al 9 used a single intravitreal ranibizumab injection to treat CNV secondary to ONHD in a 5-year-old boy. They reported that visual acuity improved to 20/25 from 20/60 and remained stable over a 12-month follow-up period 9…”

Section: Discussionmentioning

confidence: 99%

A single injection of intravitreal ranibizumab in the treatment of choroidal neovascularisation secondary to optic nerve head drusen in a child

et al. 2014

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Optic nerve head drusen are acellular, calcified deposits which may be found in buried or exposed drusen form. Choroidal neovascularisation secondary to optic nerve head drusen is rarely seen in childhood. This case report summarises the clinical and therapeutic outcomes of a 13-year-old girl with unilateral choroidal neovascularisation secondary to optic nerve head drusen. The patient was successfully treated with a single intravitreal ranibizumab injection. After a month from the injection the visual acuity increased dramatically and maintained at the same level during 9 months of follow-up time. There was no complication related to the injection.

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“…In recent years, several case reports2–8 have been published illustrating the successful use of anti-vascular endothelial growth factor (anti-VEGF) agents, such as ranibizumab and bevacizumab, for the treatment of PPCNV secondary to optic disc drusen in children. We report the first case of successful treatment using the newer intravitreal therapy, aflibercept.…”

Section: Introductionmentioning

confidence: 99%

Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

Gan

Long

2019

BMJ Case Rep

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Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.

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Long term follow-up after a single intravitreal ranibizumab injection for choroidal neovascularisation secondary to optic nerve head drusen in a 5-year-old child

Cited by 19 publications

References 6 publications

Optic disk drusen in children

Optic disk drusen in children

A single injection of intravitreal ranibizumab in the treatment of choroidal neovascularisation secondary to optic nerve head drusen in a child

Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

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