Long-Term Follow-Up after
Open Perineal Cryotherapy in
Patients with Locally Confined
Prostate Cancer

Mack, D; Jungwirth, A.; Adam, Ursula; Kunit, G.; Miller, KL; Dietze, Otto; Frick, J.

doi:10.1159/000480846

Cited by 8 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most severe complication was a rectourethral fistula after cryoablation (Clavien-Dindo IIIb). Its reported frequency usually varies from 0% to 0.6% [ 18 ] with some authors noting a rate of 6% [ 19 ]. In our study, it was observed in one patient (2.2%).…”

Section: Discussionmentioning

confidence: 99%

Whole-gland ablation therapy versus active surveillance for low-risk prostate cancer: a prospective study

Enikeev

Taratkin

Amosov

et al. 2020

Cent european J Urol

View full text Add to dashboard Cite

Introduction The objective of this study is assess the outcomes of whole-gland ablation (high-intensity focused ultrasound (HIFU), cryotherapy and brachytherapy) and active surveillance (AS) in patients with low-risk prostate cancer (PCa). Material and methods This prospective non-randomised study included 155 patients with low-risk PCa managed with either ablative therapy or AS. Follow-up included mpMRI, biopsies, prostate-specific antigen (PSA), quality of life and complications for up to 24 months. The primary endpoint was cancer progression. The secondary endpoint was the impact of each treatment on the quality of life. Results Mean total preoperative PSA was 8.8 ±1.5 ng/ml. Of 155 patients, 125 received treatment: 45 – HIFU; 45 – cryoablation; 35 – brachytherapy. Thirty were under AS. Mean nadir PSA levels were 0.64 ±0.55 ng/ml for HIFU, 0.53 ±0.38 ng/ml for cryoablation and 0.48 ±0.34 ng/ml for brachytherapy. In the AS group, mean PSA was 9.9 ±3.8 ng/ml. Biochemical relapse-free survival rates at 24 months were 81.8% for HIFU, 85% for cryoablation, 93.9% for brachytherapy and 93.3% for AS. In only one HIFU patient relapse was not confirmed on biopsy. Increased anxiety was found in up to 6.7% after treatment and in 36.7% of patients undergoing AS. The Kaplan-Meier analysis revealed no statistical differences between the techniques. Conclusions Whole-gland ablative therapy can be considered a viable treatment modality for carefully selected patients with low-risk PCa who are reluctant to select AS due to anxiety.

show abstract

Section: Discussionmentioning

confidence: 99%

Whole-gland ablation therapy versus active surveillance for low-risk prostate cancer: a prospective study

Enikeev

Taratkin

Amosov

et al. 2020

Cent european J Urol

View full text Add to dashboard Cite

show abstract

“…После проведения криотерапии это осложнение возникает в 0-0,6 % случаев [69]. Однако имеются данные, согласно которым в одном исследовании этот показатель достигал 6 % [70].…”

Section: брахитерапияunclassified

Postoperative Complications of Minimally Invasive Therapies for Prostate Cancer

et al. 2018

View full text Add to dashboard Cite

Prostate cancer is the most common cancer among men. Radical prostatectomy (open, laparoscopic, or robotic) remains the main method of surgical treatment for prostate cancer. However, minimally invasive therapies for prostate cancer are becoming increasingly popular in recent years, because they have similar efficacy as open surgery. The most studied minimally invasive therapies are cryoablation, high intensity focused ultrasound (HIFU), and brachytherapy.Despite the minimization of damage to neighboring structures, minimally invasive procedures can cause a number of complications, like any other surgical interventions. Each method has specific limitations and the most typical complications. Since multiple minimally invasive methods are currently available, we can ensure an individual approach to each particular patient, thus using the advantages of the methods and avoiding possible complications. This article covers the most frequent and severe complications of minimally invasive therapies for prostate cancer, as well as the methods of their prevention and treatment.

show abstract

“…Damals wurde mittels einer transurethralen Kryosonde das periurethrale Adenomgewebe kryotherapiert und das nekrotische Material in der Folge per Miktion ausgeschieden. Außerdem wurde die Kälte in der offenen perinealen Kryoablation genutzt, um eine kurative Therapie des lokal begrenzten Prostatakarzinoms zu ermöglichen [5]. Aufgrund einer inakzeptablen Komplikationsrate, die durch die technischen Limitationen und die mangelnden Kontrollmöglichkeiten der Methode beründet war, fand die Technik keine breite Anwendung und geriet in der Folge aus dem Fokus des allgemeinen Interesses.…”

Section: " Klinik Und Poliklinik Für Urologie Universität Zu Kölnunclassified

Kryoablation der Prostata - eine alternative Therapieoption beim lokal fortgeschrittenen Prostatakarzinom?

Derakhshani¹,

Heidenreich²,

Engelmann³

1998

Aktuel Urol

View full text Add to dashboard Cite

Zusammenfassung: Die perineale ultraschallgesteuerte Kryoablation der Prostata befindet sich seit einigen Jahren in der klinischen Erprobungsphase als Therapiealternative des Prostatakarzinoms. Sie bietet Patienten mit einem organbegrenzten Tumor, bei denen Kontraindikationen gegen eine radikale Prostatektomie vorliegen oder die eine offene radikal-chirurgische Maßnah-me ablehnen, eine minimal-invasive Option mit kurativem Potential. Die bisherigen Ergebnisse sind, was Komplikationen und Kurzzeit-Follow-up angeht, vielversprechend, jedoch fehlen Langzeitergebnisse zu Überleben und PSA-Verlauf, um den definitiven Stellenwert dieser Methode in der Therapie des organbegrenzten Prostatakarzinoms festzulegen. Die Kryoablation hat eine weitere Indikation bei lokal fortgeschrittenen Prostatakarzinomen mit extraprostatischem Wachstum, für die bis zur Entwicklung der modernen Kryotherapietechnik die kurativen Behandlungsmöglichkeiten begrenzt waren. Bei dieser Indikation hat die Kryoablation den methodischen Vorteil, daß eine Vereisung und damit eine Therapie über die Prostatakapsel hinaus möglich ist. Durch sorgfältige Operationsplanung und Erfassung der Regionen extraprostatischen Tumorwachstums kann ein lokal fortgeschrittenes Prostatakarzinom einer kurativen Maßnah-me zugeführt werden. Cryoablation of the Prostate -an Alternative Therapeutic Option in Locally Advanded Prostate Cancer?Perineal ultrasound-guided cryoablation of the prostate is being investigated as an alternative therapeutic option in the treatment of prostate cancer. If offers a minimal-invasive option with curative potential for patients with localized disease, who present with contraindications to radical prostatectomy, or who are not willing to undergo a radical procedure. Results concerning complications and short-term follow-up are promising, but lacking long-term results on survival and biochemical failure rates prevent definition of the significance of this procedure in the treatment of localized prostate cancer. Cryoablation also has an indication in locally advanced prostate cancer with extraprostatic extension, for which curative therapeutic concepts were limited until recent development of modern cryosurgery. In this setting cryosurgery has the technical advantage to freeze beyond the prostate capsule, so that even patients with capsular penetration might be cured. Careful preoperative planning and recognition of areas of extraprostatic extension might result in a potentially curative therapy in locally advanced prostate cancer.

show abstract

Long-Term Follow-Up after Open Perineal Cryotherapy in Patients with Locally Confined Prostate Cancer

Cited by 8 publications

References 5 publications

Whole-gland ablation therapy versus active surveillance for low-risk prostate cancer: a prospective study

Whole-gland ablation therapy versus active surveillance for low-risk prostate cancer: a prospective study

Postoperative Complications of Minimally Invasive Therapies for Prostate Cancer

Kryoablation der Prostata - eine alternative Therapieoption beim lokal fortgeschrittenen Prostatakarzinom?

Contact Info

Product

Resources

About