Long‐term follow‐up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy

Canonne, A.M.; Bolen, Géraldine; Peeters, Dominique; Billen, Frédéric; Clercx, Cécile

doi:10.1111/jsap.12529

Cited by 19 publications

(45 citation statements)

References 30 publications

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“…In group 3a disorders, recommended treatment is primarily symptomatic and includes cough suppression, sedation, oxygen supplementation, and, when present, control of secondary infection and inflammation. Specific examples may include, but are not limited to, glucocorticoids, opioids or other sedatives, antimicrobials, and antitussives . For management of severe tracheal collapse, placement of an intraluminal stent can be considered …”

Section: Treatmentmentioning

confidence: 99%

“…Whole lung lavage has been described to treat pulmonary alveolar proteinosis . Corticosteroids are the primary treatment for eosinophilic lung disease In dogs with group 3b2 disorders in which infection underlies pathology, appropriate antimicrobials are recommended.…”

Section: Treatmentmentioning

confidence: 99%

“…glucocorticoids, opioids or other sedatives, antimicrobials, and antitussives. 181,[185][186][187][188] For management of severe tracheal collapse, placement of an intraluminal stent can be considered. 189,190 • Consensus in 7/7 members of the panel and 5/5 advisory reviewers T7.…”

Section: Group 1 Pahmentioning

confidence: 99%

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ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Reinero

Visser

Kellihan

et al. 2020

Veterinary Internal Medicne

192

383

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Pulmonary hypertension (PH), defined by increased pressure within the pulmonary vasculature, is a hemodynamic and pathophysiologic state present in a wide variety of cardiovascular, respiratory, and systemic diseases. The purpose of this consensus statement is to provide a multidisciplinary approach to guidelines for the diagnosis, classification, treatment, and monitoring of PH in dogs. Comprehensive evaluation including consideration of signalment, clinical signs, echocardiographic parameters, and results of other diagnostic tests supports the diagnosis of PH and allows identification of associated underlying conditions. Dogs with PH can be classified into the following 6 groups: group 1, pulmonary arterial hypertension; group 2, left heart disease; group 3, respiratory disease/hypoxia; group 4, pulmonary emboli/pulmonary thrombi/pulmonary thromboemboli; group 5, parasitic disease (Dirofilaria and Angiostrongylus); and group 6, disorders that are multifactorial or with unclear mechanisms. The approach to treatment of PH focuses on strategies to decrease the risk of progression, complications, or both, recommendations to target underlying diseases or factors contributing to PH, and PH‐specific treatments. Dogs with PH should be monitored for improvement, static condition, or progression, and any identified underlying disorder should be addressed and monitored simultaneously.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Reinero

Visser

Kellihan

et al. 2020

Veterinary Internal Medicne

192

383

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“…In EBP, an underlying immunologic hypersensitivity is suspected, but the inciting antigens remain mostly unidentified (Clercx et al, 2002;Peeters et al, 2005;Clercx and Peeters, 2007). For both of these bronchial diseases, current treatments consist of long-term oral and/or inhaled glucocorticoids (Clercx et al, 2000;Bexfiels et al, 2006;Rozanski, 2014;Canonne et al, 2016b).…”

Section: Introductionmentioning

confidence: 99%

Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs

Canonne

Peters

Roels

et al. 2018

The Veterinary Journal

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In humans, Mycoplasma pneumoniae and Bordetella pertussis infections are suggested to trigger or exacerbate asthma. Whether Mycoplasma or Bordetella are associated with chronic inflammatory bronchial diseases in dogs has not been investigated. The aim of this study was to assess detection rates of Mycoplasma canis (M. canis), M. cynos and Bordetella bronchiseptica (Bb), in dogs with eosinophilic bronchopneumopathy (EBP) and chronic bronchitis (CB), compared with healthy dogs. Specific quantitative PCR (qPCR) analysis for M. canis, M. cynos and Bb were retrospectively performed on bronchoalveolar lavage fluid (BALF) collected from 24 dogs with EBP, 21 dogs with CB and 15 healthy dogs. Possible associations between qPCR results and age, BALF cytology or clinical severity scores (CSS) in dogs with EBP were investigated. There was no difference in M. canis, M. cynos and Bb detection rates in dogs with EBP (n=6, n=2 and n=6, respectively) and dogs with CB (n=2, n=2 and n=2, respectively) compared with control dogs (n=4, n=2 and n=2, respectively). In dogs with EBP, the proportion that were qPCR-positive for Bb was higher in dogs with higher CSS (P=0.014) and BALF from Bb-positive dogs had higher percentage of neutrophils (P<0.001). Among dogs that were qPCR-positive for Bb, moderate to high loads were only detected in dogs with EBP. M. canis and M. cynos detection was not associated with EBP or CB; higher Bb loads were only present in dogs with EBP and high CSS. A possible cause and effect relationship between Bb infection or load and EBP remains unclear and requires further investigation.

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“…Fluticasonpropionat, ein weiteres lokal wirksames Kortisonderivat für den inhalativen Einsatz, ist auch in der Kombination mit Salmeterol als Aerosol erhältlich. Katzen und eingeschränkt auch Hunde mit chro nischer Bronchitis sprachen klinisch gut auf eine Inhalations behandlung mit Fluticasonpropionat an (21,59). Die Aerosole können über eine Inhalationskammer verabreicht werden, um eine bessere Verteilung in der Lunge zu gewährleisten (▶ Abb.…”

Section: Glukokortikoideunclassified

Immunsuppressive Therapie bei Hunden und Katzen. Eigenschaften von Wirkstoffen und ihre Anwendung bei verschiedenen immunvermittelten Erkrankungen

Rieder¹,

Mischke²

2018

Tierarztl Prax Ausg K

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ZusammenfassungTierärzte werden regelmäßig mit der Diagnose und Therapie immunvermittelter Erkrankungen konfrontiert. Zu den häufigeren Erkrankungen gehören die immunvermittelte hämolytische Anämie, die immunvermittelte Thrombozytopenie und Polyarthritis. Aufgrund ihrer Verfügbarkeit, Effizienz und schnellen Wirkung sind Glukokortikoide Mittel der ersten Wahl. Einige Patienten mit immunvermittelten Erkrankungen sprechen jedoch nicht auf eine alleinige Therapie mit Glukokortikoiden an. Bei anderen Patienten muss infolge schwerwiegender Nebenwirkungen zeitnah eine Dosisreduktion der Glukokortikoide erfolgen. In solchen Fällen ist die Anwendung ergänzender Medikamente indiziert. Für Ciclosporin gibt es zugelassene Präparate in der Veterinärmedizin. In der Literatur ist auch der Einsatz von Azathioprin, Mycophenolat-Mofetil und humanen Immunglobulinen beschrieben. Der Artikel gibt einen Überblick über die Wirkmechanismen einzelner immunmodulierender Substanzen sowie deren in der aktuellen Literatur beschriebenen Einsatz bei ausgewählten Erkrankungen.

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Long‐term follow‐up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy

Cited by 19 publications

References 30 publications

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs

Immunsuppressive Therapie bei Hunden und Katzen. Eigenschaften von Wirkstoffen und ihre Anwendung bei verschiedenen immunvermittelten Erkrankungen

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