Long-term follow-up of 123 patients with adenocarcinoma of the sinonasal tract treated with endoscopic resection and postoperative radiation therapy

Camp, Sophie; Gerven, Laura Van; Poorten, Vincent Vander; Nuyts, Sandra; Hermans, Robert; Hauben, Esther; Jorissen, Mark

doi:10.1002/hed.23900

Cited by 78 publications

(103 citation statements)

References 25 publications

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“…In our institution, we did not opt for a step down protocol, as we first wanted to validate the endoscopic approach per se in ADC management. In accordance with a large retrospective study of 123 ITAC treated with ESS [20], we still not considered ESS as a single treatment modality for primary early stage ITAC. Noteworthy, postoperative RT, which may be delayed by wound healing in open procedures, can be administrated immediately following ESS [15].…”

Section: Discussionsupporting

confidence: 64%

“…Like Nicolai et al [9], we advocate a complete centripetal ethmoid sinus resection even for limited tumours. Recent studies advocate for a bilateral ethmoidectomy to prevent local recurrences controlaterally, in particular in the cases of ascertained occupational exposure [19,20]. Our attitude is strengthened by observations of preneoplastic and neoplastic foci in macroscopically uninvolved ethmoid areas in particular in patients exposed to carcinogenetic dusts [21].…”

Section: Discussionmentioning

confidence: 76%

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Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Mortuaire

Leroy

Vandenhende‐Szymanski

et al. 2016

Eur Arch Otorhinolaryngol

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Endoscopic sinus surgery (ESS) is considered as a valid option in the management of nasal adenocarcinoma (ADC). Comparative studies with open approaches are still required. A monocentric retrospective study was carried out from May 2002 to December 2013, including 43 patients with intestinal-type adenocarcinoma of the ethmoid sinus. Non-resectable tumours or recurrences were excluded. Before 2008, open approach with lateral rhinotomy (LR) was performed as the gold standard of treatment. From 2008, ESS was systematically used as a first-line option as long as a complete resection was achievable. Adjuvant radiation therapy was delivered (RT) for all the patients. LR and ESS were performed in, respectively, 23 and 20 patients. The two groups were comparable in terms of age, occupational dust exposure, histopathological subtypes, and T stage based on the pathological assessment of the specimen (10 pT2, 26 pT3, 2 pT4a, and 5 pT4b). The tumour origin was mainly located in the olfactory cleft with the involvement of the cribriform plate in 60 % of patients. No major complication was observed in ESS group with a reduced hospital stay (5.6 vs 7.6 days). The disease-free survival was not different between LR and ESS groups over a mean follow-up period of 6.6 years. Even for local advanced stages with skull base involvement, we confirm the reliability and the advantages of ESS in terms of oncological outcomes and morbidity. We advocate complete excision of the olfactory cleft to ensure an appropriate control of the tumoral origin.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 76%

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Mortuaire

Leroy

Vandenhende‐Szymanski

et al. 2016

Eur Arch Otorhinolaryngol

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“…Postoperative imaging fi ndings indicate that the olfactory cleft is rarely involved in recurrence, most likely due to its access during endoscopic surgery, whereas in our study the fovea ethmoidalis (47%; n=8/17), the posterior ethmoid (41%; n=7/17) and the lamina papyracea, essentially in its inferior part (41%; n=7/17) are sites of predilection for recurrence of ADK [ Figure 3]. Camp et al [7] also found favored sites of recurrence in the posterior ethmoid (45%), the fovea ethmoidalis (35%), but equally in the posterior part of the nasal septum (27%), not found in our study population. Bely et al [15], in a study which is now slightly dated, This standpoint in relation to monitoring has yet to be assessed in a prospective multicenter study, involving larger populations and with greater follow-up, in order to evaluate long-term survival in terms of benefi t. However, the low sample size of the various groups hampers data exploitation of this kind.…”

Section: Discussionmentioning

confidence: 59%

“…To our knowledge, this study is the fi rst of its kind to attempt an objective evaluation of MRI performance in early detection of recurrence or tumor residue in carcinoma of the ethmoid sinus and to identify the predominant sites prone to risk [7].…”

Section: Resultsmentioning

confidence: 99%

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Postoperative Correlation of Radiological and Surgical Findings in Management of Ethmoid Sinus Adenocarcinoma

Prampart¹,

Djennaoui²,

Çiftci³

et al. 2017

Arch Otolaryngol Rhinold

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Treatment‐related morbidity in patients treated for sinonasal malignancy

Patel

Chitguppi

Vimawala

et al. 2020

Int Forum Allergy Rhinol

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Background: Sinonasal malignancies are a rare, heterogeneous group of tumors that o en present at an advanced stage and require multimodal therapy. The presence of high-grade toxicity and sinonasal complications a er treatment can negatively impact quality of life. In this study we aim to describe pos reatment morbidity in patients with sinonasal malignancy. Methods:A retrospective analysis of all patients treated for sinonasal malignancy was conducted from 2005 to 2018 at a tertiary referral institution. A total of 129 patients met the inclusion criteria. Primary outcomes were treatment details, pathology, pos reatment complications, and radiation toxicity. Fisher's exact test, chi-square test, and Student t test were used for statistical analysis.Results: Mean age was 58.4 (median, 61; range, 19-94) years. A er diagnosis, 24 patients had surgery alone, 46 had surgery with radiation alone, 47 had surgery with chemoradiation, and 14 received definitive chemoradiation. Overall, 10.4% (n = 12) of patients had postoperative complications, and 21.0% (n = 22) had high-grade (grade 3-5) radiation toxicity. A er radiation, 20% (n = 21) of patients had chronic sinusitis requiring functional endoscopic sinus surgery and 20% (n = 21) had symptomatic nasal obstruction requiring operative debridement. Conclusion:Sinonasal complications, including nasal obstruction and chronic sinusitis, occur frequently a er definitive treatment of sinonasal malignancy and should be addressed when considering quality of life in survivors. These complications occur more frequently in patients who undergo chemoradiation as opposed to surgery alone. C 2020 ARS-AAOA, LLC.

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Long-term follow-up of 123 patients with adenocarcinoma of the sinonasal tract treated with endoscopic resection and postoperative radiation therapy

Abstract: This large study of sinonasal adenocarcinoma primarily treated with endoscopic resection and RT confirms that this approach results in good oncologic and functional outcome.

Cited by 78 publications

References 25 publications

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Postoperative Correlation of Radiological and Surgical Findings in Management of Ethmoid Sinus Adenocarcinoma

Treatment‐related morbidity in patients treated for sinonasal malignancy

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