long-term follow-up of anglian germ cell cancer group surveillance versus patients with stage 1 nonseminoma treated with adjuvant chemotherapy

Oliver, R. T. D.; Ong, J.; Shamash, Jonathan; Ramamurthi, Ravi; Nagund, V; Harper, Peter; Ostrowski, Marek; Sizer, Bruce; Levay, J.; Robinson, A.; Neal, DE; Williams, Michael

doi:10.1016/j.urology.2003.10.023

Cited by 98 publications

(60 citation statements)

References 30 publications

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“…The Medical Research Council in the United Kingdom has conducted a randomized phase III study of 1447 patients comparing adjuvant radiotherapy and a single course of carboplatin. 37 The relapse rate in both arms of the study was similar at 3 years (3.4% radiotherapy vs. 4.6% carboplatin) with most of the recurrences in the carboplatin arm occurring in the retroperitoneal lymph nodes. One possible benefit of adjuvant carboplatin noted in this setting was a reduction in the incidence of second primary testicular GCTs.…”

Section: Adjuvant Chemotherapymentioning

confidence: 76%

Canadian consensus guidelines for the management of testicular germ cell cancer

Wood

Kollmannsberger

Jewett

et al. 2013

CUAJ

123

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Section: Adjuvant Chemotherapymentioning

confidence: 76%

Canadian consensus guidelines for the management of testicular germ cell cancer

Wood

Kollmannsberger

Jewett

et al. 2013

CUAJ

123

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“…Due to advances in combination chemotherapy, the 10-year disease-specific survival rate in patients with metastatic NSGCTs is 88% (6). However, 30% of patients with stage I NSGCTs relapse during active surveillance (7)(8)(9). Chemotherapy containing CDDP has been introduced as an adjuvant treatment option for micrometastatic disease, thereby reducing the risk of relapse to 2% (10).…”

Section: Introductionmentioning

confidence: 99%

Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas

et al. 2015

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Abstract. Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell lines (NEC8 and NEC14), with the treated cells evaluated in relation to cisplatin (CDDP) resistance, differentiation (using Vimentin, Fibronectin, TRA-1-60, and SSEA-1 and -3 as markers) and stemness (denoted by expression of SOX2 and OCT3/4). Furthermore, DNA methyltransferase (DNMT-1, -3A and -3L) expression and methylation status were analyzed. DMSO induced resistance to CDDP, aberrant differentiation and reduction of stemness-related markers in each of the EC cell lines. The expression levels of DNMT-3L and -3A were reduced in response to DMSO, while this treatment also affected DNA methylation. The data demonstrated that DMSO perturbed differentiation, reduced stemness and induced resistance to CDDP in human EC cells. Therefore, DMSO could reduce drug efficacy against EC cells and its use should be carefully managed in the clinical application of chemotherapy.

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“…Mantiene no sólo un rol estadificador si no que también terapéutico, pudiendo evitarse el tratamiento quimioterápico en un grupo importante de pacientes. Los protocolos de vigilancia tiene una tasa de recurrencia de 30%; en el 35% de los casos los marcadores tumorales son normales y aproximadamente el 60% de estas recurrencias ocurre en el retroperitoneo [12][13][14] . En los esquemas de quimioterapia primaria o ayudante, la recurrencia baja al 2,7%, pero existe el problema de los efectos deletéreos a largo plazo (más de 20 años) como son la aparición de cánceres secundarios y la probabilidad alta de enfermedad cardiovascular y síndrome metabólico [15][16][17][18] .…”

Section: Discussionunclassified

Linfadenectomía retroperitoneal lumboaórtica laparoscópica por vía extraperitoneal en cáncer testicular no seminoma

C¹

2013

Rev Chil Cir

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Extraperitoneal laparoscopic retroperitoneal lymph node dissection in non-seminomatous testicular cancerObjective: The aim is to describe the technique of extraperitoneal laparoscopic access for retroperitoneal lymph node dissection in a series of patients with testis cancer stage A. Material and Methods: The extraperitoneal approach was performed in 5 patients with stage A testicular cancer. The technique includes the creation of a totally extraperitoneal space, full exposition of the retroperitoneum and classic retroperitoneal lymph node dissection. We analyzed demographic data, histology, access and surgical complications, estimated blood loss and follow up. Results: The average age was 29.4 years old (22-41). The mean operative time was 144 minutes, with an estimated blood loss of 42.4 ml. There were no surgical complications. The average hospital stay was 33.6 hr, and mean number of lymph nodes was 27.4 (24 -32). In long-term follow up there was no recurrence. Discussion: The extraperitoneal approach is an alternative access for retroperitoneal lymph node dissection in testis cancer patients. It allows avoiding potential intestinal lesions and there is no contraindication in patients with prior abdominal surgery.Key words: Retroperitoneal lymph node dissection, testis cancer, laparoscopy, extraperitoneal. ResumenObjetivo: Mostrar la experiencia en la técnica de disección lumboaórtica por vía totalmente extraperitoneal, en un grupo de pacientes con cáncer testicular en estadio A. Material y Métodos: La serie está formada por 5 pacientes, portadores de un tumor testicular no seminoma, en estadio A. En ellos se planteó como alternativa la linfadenectomía retroperitoneal lumboaórtica laparoscópica. La técnica quirúrgica consistió en la formación de un espacio extraperitoneal, con rechazo de peritoneo, exposición del retroperitoneo y disección linfática clásica. Se analizaron los datos demográficos, histología, complicaciones del acceso y la

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long-term follow-up of anglian germ cell cancer group surveillance versus patients with stage 1 nonseminoma treated with adjuvant chemotherapy

Cited by 98 publications

References 30 publications

Canadian consensus guidelines for the management of testicular germ cell cancer

Canadian consensus guidelines for the management of testicular germ cell cancer

Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas

Linfadenectomía retroperitoneal lumboaórtica laparoscópica por vía extraperitoneal en cáncer testicular no seminoma

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