Long-Term Follow-Up of Cellular Proliferation as a Predictive Index for the Relapse of Nasal Polyposis

Abstract

We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.

Evaluation of Telomerase Activity in Nasal Polyps

“…Moreover, the existence of polyps with a different cell replication rate has been described consistently. 7 In all cases, the rate of replicating cells in connective and epithelium components is similar. 8 Moreover, a substantial replicative activity can be observed also in inflammatory cells, which infiltrate nasal polyps.…”

“…8 A previous report showed a relationship between cell proliferative rate and the tendency of polyps to recur. 7 We investigated whether nasal polyps express telomerase activity and, if so, whether a difference could be found between the polyp and the sorrounding mucosa of the middle meatus and between different portions of the polyp itself. The first observation was that telomerase activity can be found in almost all polyps and that this activity seems to be much higher than that expressed in specimens taken from nasal mucosa.…”

Could Cellular Proliferation Be a Predictive Index for the Relapse of Nasal Polyposis and Down-Regulated by Nasal Steroid Treatment?

“…By using flow cytometry, the percentage of cells in the S phase is found at higher concentration in patients suffering from relapsing polyposis. It is reported that hyperproliferative ability is higher at recurrent polyps [11]. Nasal polyps with recurrent disease displayed higher scores for proliferation markers.…”

“…Although suitable surgical and medical treatments were performed, the recurrence of the polyps could not be prevented. A few study reported about the detection of the recurrent polyps proliferative activity [11]. By using flow cytometry, the percentage of cells in the S phase is found at higher concentration in patients suffering from relapsing polyposis.…”

The Bhopal disaster and its aftermath: a review

“…In the fall of 2001, steel from the ruins of the World Trade Center was exported to India apparently without first being tested for contamination from asbestos and heavy metals present in the twin tower debris. Other examples of poor environmental stewardship and economic considerations taking precedence over public health concerns abound [24]. …”