Long-term follow-up of central serous retinopathy in 150 patients

Abstract

To study the evolution of the retinal pigment epithelial lesions in the central serous retinopathy, the authors studied 150 patients with ages between 20 and 49 years at the first examination, during periods varying between 6 months and 14 years. It was found a greater incidence of the disease in the males (83.3%); bilaterality in 23.3%; only one point of leakage in 62.7%; 3 different types of diffusion (inkblot 71.4%; mushroom 23.8%; with serous pigment epithelial detachment 4.9%). The final visual acuity was < 20/40 in a quarter of the cases and the frequency of the recurrences was 30%. The laser treatment did not influence the recurrences. In 50 patients with a follow-up superior to 3 years, 8 (16%) developed lesions similar to those described as diffuse retinal pigment epitheliopathy with visual field defects and subnormal EOG. Actuarial calculus suggests that 50% of the patients may get the most severe and extensive form of the disease after 12 years of evolution. The results allow to conclude that the diffuse retinal pigment epitheliopathy is only the terminal state of the most severe cases of central serous retinopathy.

Central Serous Chorioretinopathy

“…Historically, its occurrence has mainly been associated with men in their 30s to 40s. Indeed, although only one population-based study and no systemic epidemiologic survey of CSC has been carried out, a large number of single studies support the idea of men being more often affected than women, presenting male-to-female ratios of up to 8:1 [9,10,11,12,13,14]. The mean age of patients affected is quoted variably in these studies but seems to be slightly higher than usually assumed, with a peak at around 40-45 years in men, although some studies suggest even higher mean ages for men [15,16,17,18] and particularly for women and patients with chronic CSC [8,11,19].…”

Five to 15 year follow-up of resolved idiopathic central serous chorioretinopathy

“…Castro-Correia et al 6 suggested that 50% of the patients may get the most severe form of the disease after 12 years of evolution. Although our data were statistically insignificant, there does not seem to be a trend showing severity with time elapsed.…”

Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy

“…Keywords Central serous chorioretinopathy Á Idiopathic central serous retinopathy Á Spectral domain Á Optical coherence tomography Idiopathic central serous chorioretinopathy (ICSC) is a disease of young and middle-aged adults that frequently manifests symptomatically in one eye, while 5-18% of cases may be bilateral at time of presentation [1][2][3][4]. Several reports on fluorescein and indocyanine green angiography and multifocal electroretinography indicate that the disease process in ICSC is more diffuse and shows bilateral retinochoroidal dysfunction, even though the disease may be manifesting clinically only in one eye [4][5][6][7][8].…”