Long-term follow-up of children with prenatally diagnosed omphalocele and gastroschisis

Lunzer, H.; Menardi, G; Brezinka, C

doi:10.1080/714052779

Cited by 17 publications

(23 citation statements)

References 17 publications

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“…[8][9][10][11]13 In studies published more than 20 years ago, 30 to 40% of survivors were less than the 10th percentile for weight at follow-up. 8,13,20 Berseth et al 8 described a case series of infants with either gastroschisis or omphalocele, who were born between 1964 and 1977, and observed minimal catch-up growth for both weight and length.…”

Section: Discussionmentioning

confidence: 99%

“…8,11,12,23 Lunzer et al 11 conducted interviews of parents of 10 gastroschisis survivors at 3 to 12 years of age. Two reported a learning disability, and one reported mental retardation.…”

Section: Discussionmentioning

confidence: 99%

“…6 The impact of gastroschisis on growth and neurodevelopment, based on previous studies, is uncertain because of limitations in study design, including small cohort sizes, the inclusion of patients with unrelated abdominal wall defects, evaluations by report only and the inclusion of patients born greater than 20 years ago. [8][9][10][11] As a result, some studies report normal growth, and others report a high percentage of growth failure. [11][12][13] Neurodevelopmental findings also vary, with both impaired development 8 and normal development 12 reported.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] As a result, some studies report normal growth, and others report a high percentage of growth failure. [11][12][13] Neurodevelopmental findings also vary, with both impaired development 8 and normal development 12 reported. Advances over the past 15 years in neonatal care, including improved respiratory management and parenteral nutrition, may have improved long-term growth and neurodevelopment.…”

Section: Introductionmentioning

confidence: 99%

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Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis

et al. 2008

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Objective: To examine growth, neurodevelopment and morbidity in infants with gastroschisis. Study Design:We enrolled all infants with gastroschisis treated at the North Carolina Children's Hospital from March 2003 through June 2005. Neonatal data were collected. Medical history, growth and neurodevelopment were assessed at 16 to 24 months.Result: Of 24 infants, 17 completed follow-up. Weight and length were below the 10th percentile for five and six infants, respectively. Three infants scored less than 85 on the Bayley Scales of Infant Development, second edition. Small for gestational age (SGA) infants were smaller and had lower neurodevelopmental scores. Fourteen experienced continued bowel dysfunction; nine were rehospitalized. Conclusion:One-third of infants with gastroschisis experience growth delay. Infants who are SGA are at higher risk, suggesting that postnatal growth may be influenced by fetal phenomena, and may not be modifiable. Neurodevelopment is not delayed. Continued bowel dysfunction is common.

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Section: Discussionmentioning

confidence: 99%

“…8,11,12,23 Lunzer et al 11 conducted interviews of parents of 10 gastroschisis survivors at 3 to 12 years of age. Two reported a learning disability, and one reported mental retardation.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis

et al. 2008

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“…Poor long-term outcomes for infants with omphalocele are more likely in the presence of associated structural or chromosomal abnormalities that occur in approximately 50-77% of these infants [2,3,4]. Other factors associated with poor outcomes include early respiratory distress [5], presence of liver within the omphalocele sac [6], high in utero omphalocele diameter to abdominal circumference ratio [7], low birth weight, low gestational age, and antenatal rupture of the sac [8].…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

Hutson

Baerg²,

Deming³

et al. 2017

Neonatology

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Background: Omphalocele is one of the most common abdominal wall defects. Many newborn infants born with omphalocele present with significant respiratory distress at birth, requiring mechanical ventilatory support, and have clinical evidence of pulmonary hypertension. Little information exists on the prevalence of and risk factors associated with pulmonary hypertension in this cohort of infants. Objectives: To describe the prevalence of and risk factors associated with pulmonary hypertension among infants with omphalocele. Methods: This is a multicenter retrospective chart review of demographic data and clinical characteristics of infants with omphalocele admitted to the neonatal intensive care units of Loma Linda University Children's Hospital and Children's Mercy Hospital between 1994 and 2011. Echocardiogram images were reviewed for pulmonary hypertension, and statistical analyses were performed to identify risk factors associated with the presence of pulmonary hypertension. Results: Pulmonary hypertension was diagnosed in 32/56 (57%) infants with omphalocele. Compared to infants without pulmonary hypertension, infants with pulmonary hypertension were more likely to have a liver-containing defect (16/32 [50%] vs. 5/24 [21%], p = 0.03), require intubation at birth (18/32 [56%] vs. 6/24 [17%], p = 0.03), and die during initial hospitalization (12/32 [38%] vs. 2/24 [8%], p = 0.01). Conclusion: The majority of infants with omphalocele have evidence of pulmonary hypertension which is associated with increased mortality. Echocardiograms to screen for pulmonary hypertension should be obtained at ≥2 days of life in infants with omphalocele, especially in those with liver within the omphalocele sac and/or in those infants who require intubation at birth to screen for pulmonary hypertension.

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Genitourinary infection and gastroschisis: A systematic review and meta‐analysis

Vinogradov,

Muthupunnackal,

Moffat

et al. 2024

Birth Defects Research

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BackgroundGastroschisis is a congenital anomaly of the umbilical ring with increasing prevalence, especially amongst younger mothers. There is increasing evidence that exposure to genitourinary infections (GUTI) may play an important role in the etiology of gastroschisis. This systematic review and meta‐analysis aimed to identify, appraise, and summarize the literature on exposure to GUTI and gastroschisis.MethodsSix electronic databases (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane Library electronic databases, and Prospero) were searched using a comprehensive search strategy. Citations and cited articles for all included studies were searched. Peer‐reviewed, quantitative studies reporting an association of urinary tract infections (UTI) and/or sexually transmitted infections (STI) with gastroschisis were included. Prospero registration CRD42022377420.ResultsA total of 2392 papers were identified via the searches of which 15 met our inclusion criteria and were included after title and abstract and full text screening. The study period for included studies ranged from 1995 to 2016, most were from the USA. Four studies considering exposure to STIs and five to UTIs were eligible to progress to meta‐analysis. Meta‐analysis identified a significantly increased risk of gastroschisis in association with periconceptional exposure to UTI [OR 1.54 (95% CI 1.29, 1.8)], STI [OR 1.4 (95% CI 1.01, 1.79)].ConclusionsPericonceptional exposure to GUTI is associated with an increased risk of gastroschisis. The prevention and timely treatment of GUTI amongst women of childbearing age may help to reduce the occurrence of gastroschisis.

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Long-term follow-up of children with prenatally diagnosed omphalocele and gastroschisis

Cited by 17 publications

References 17 publications

Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis

Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis

High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

Genitourinary infection and gastroschisis: A systematic review and meta‐analysis

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