Long-Term Follow-Up of Conventional Polyethylene in Total Hip Arthroplasty in Young Patients: Heightened Wear-Related Complications Are Observed at the Beginning of the Third Decade

Parilla, Frank W; Ince, Deniz C.; Pashos, Gail; Maloney, William J.; Clohisy, John C.

doi:10.1016/j.arth.2022.04.011

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-term data from the government-funded Australian arthroplasty registry demonstrated marked reduction in revision arthroplasty, from 18% to 6%, with use of highly cross-linked polyethylene compared with conventional polyethylene at 16 years 33 . A 20-year follow-up of higher-demand patients <50 years old who received highly cross-linked polyethylene showed no material failures 34 . With more than 1 million total hip replacements performed worldwide in 2017 35 , this collaborative research effort has benefited millions of patients and reduced the need for tens of thousands of costly revision hip procedures.…”

Section: The Impact Of Polyethylene Research On Joint Replacement Out...mentioning

confidence: 92%

How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration

Chu,

Murray,

Maloney

et al. 2023

Journal of Bone and Joint Surgery

Self Cite

View full text Add to dashboard Cite

Improving the performance and impact of orthopaedic research is a critical leadership challenge. Musculoskeletal (MSK) conditions are a leading cause of disability worldwide, for which research investment and performance lags far behind the burden of disease. In the United States, MSK disorders account for the highest health care costs, have increased in incidence at the fastest rate, and exceed the combined costs of cardiovascular diseases and neoplasms. Despite the cost to society, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), with primary responsibility for MSK research, receives <1.4% of the funds allocated to the National Institutes of Health (NIH). Although orthopaedic surgeons are leading providers of MSK clinical care, the dearth of orthopaedic clinician-scientists also greatly reduces representation of MSK scientific and clinical expertise among academic and scientific leaders. The goals of this symposium were to highlight the critical need for greater prioritization and investment in orthopaedic research and to engage orthopaedic leaders in addressing these needs. Compelling stories of research success from 3 orthopaedic chairs were featured to highlight how orthopaedic surgeon leadership in bench-to-bedside research substantially advances MSK clinical care. Seminar participants also emphasized the need to improve evidence-based clinical practice for which multicenter prospective cohort and registry studies represent opportunities for broader involvement. Prioritization of orthopaedic clinician-scientist development and formation of multidisciplinary partnerships with basic and translational scientists were emphasized as critical needs to advance MSK health. It is critical for orthopaedic chairs to “be invested in” and to “invest in” the success of orthopaedic research. This investment includes developing a professional climate that values research achievement and collaboration as well as implementing strategies to support and sustain research success. Finally, orthopaedic leaders need to advocate for federal research funding to be proportional to the economic burden of disease for which MSK conditions carry the highest current and projected costs. With health-care costs accounting for nearly one-fifth of the U.S. economy, increasing the investment in orthopaedic research to reduce the prevalence, disability, and morbidity from MSK disease needs to be a top orthopaedic and national leadership priority.

show abstract

Section: The Impact Of Polyethylene Research On Joint Replacement Out...mentioning

confidence: 92%

How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration

Chu,

Murray,

Maloney

et al. 2023

Journal of Bone and Joint Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…Conventional ultra-high molecular weight polyethylene (UHMWPE) remains one of the most commonly utilized materials for liners or inserts in contemporary total hip and knee arthroplasties [ 12 ]. However, long-term observations of conventional PE liners in total hip arthroplasty [ 13 – 17 ] and total knee arthroplasty [ 18 – 20 ] indicated high rates of PE wear and wear-related revisions. Parilla et al [ 17 ] recently identified a marked increase in wear-related revisions, manifested as severe liner wear, osteolysis, implant loosening, and secondary instability, along with a decline in survivorship between the 15-year (87.9%) and 25-year (61.1%) post-operative periods.…”

Section: Introductionmentioning

confidence: 99%

“…However, long-term observations of conventional PE liners in total hip arthroplasty [ 13 – 17 ] and total knee arthroplasty [ 18 – 20 ] indicated high rates of PE wear and wear-related revisions. Parilla et al [ 17 ] recently identified a marked increase in wear-related revisions, manifested as severe liner wear, osteolysis, implant loosening, and secondary instability, along with a decline in survivorship between the 15-year (87.9%) and 25-year (61.1%) post-operative periods. These findings underscore the clinical significance of PE wear for both the short-term and long-term survivorship of implants.…”

Section: Introductionmentioning

confidence: 99%

Mitigating polyethylene-mediated periprosthetic tissue inflammation through MEDSAH-grafting

Park,

Chang,

Lee

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Periprosthetic tissue inflammation is a challenging complication arising in joint replacement surgeries, which is often caused by wear debris from polyethylene (PE) components. In this study, we examined the potential biological effects of grafting a [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSAH) polymer onto the surface of PE through a solvent-evaporation technique. J774A.1 macrophage-like cells and primary cultured mouse osteoblasts were treated with PE powder with or without the MEDSAH coating. MEDSAH grafting on PE substantially reduced the expression of pro-inflammatory cytokines and other mediators in primary cultured mouse osteoblasts, but did not significantly impact macrophage-mediated inflammation. Our findings suggest that a MEDSAH coating on PE-based materials has potential utility in mitigating periprosthetic tissue inflammation and osteolysis and preventing aseptic loosening in total joint replacements. Further research, including large-scale clinical trials and biomechanical analyses, is needed to assess the long-term performance and clinical implications of MEDSAH-coated PE-based materials in total joint arthroplasty.

show abstract

Primary Total Hip Arthroplasty in Juvenile Idiopathic Arthritis: Survivorship After a Median Follow-Up of 12 Years

Warren,

Hwang,

Lee

et al. 2024

The Journal of Arthroplasty

View full text Add to dashboard Cite

Long-Term Follow-Up of Conventional Polyethylene in Total Hip Arthroplasty in Young Patients: Heightened Wear-Related Complications Are Observed at the Beginning of the Third Decade

Cited by 4 publications

References 28 publications

How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration

How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration

Mitigating polyethylene-mediated periprosthetic tissue inflammation through MEDSAH-grafting

Primary Total Hip Arthroplasty in Juvenile Idiopathic Arthritis: Survivorship After a Median Follow-Up of 12 Years

Contact Info

Product

Resources

About