2004
DOI: 10.1007/s00467-004-1701-z
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Long-term follow-up of Epstein-Barr virus viremia in pediatric recipients of renal transplants

Abstract: The common observation of Epstein-Barr virus (EBV) viremia in pediatric recipients of renal transplants and the occurrence of an EBV-related pulmonary leiomyoma prompted us to intensify the follow-up of EBV infections from 1995 to October 2000. Follow-up included serology and detection of viral DNA in blood using a semi-quantitative nested polymerase chain reaction (PCR) and later a real-time PCR with higher sensitivity. The aim of this study was the early detection of primary infections or reactivations. We o… Show more

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Cited by 16 publications
(9 citation statements)
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“…The majority of these patients remain on triple immunosuppression therapy consisting of a CNI, an antiproliferative agent and steroids. Nevertheless, these drugs are frequently associated with severe complications, including but not limited to infection, dyslipidemia, new‐onset post‐transplant diabetes mellitus, high blood pressure, nephrotoxicity, and more seriously to the EBV‐related PTLD (2–10). The main purpose of post‐transplant surveillance is preventing rejection, optimizing long‐term graft function, and minimizing post‐transplant complications.…”
mentioning
confidence: 99%
“…The majority of these patients remain on triple immunosuppression therapy consisting of a CNI, an antiproliferative agent and steroids. Nevertheless, these drugs are frequently associated with severe complications, including but not limited to infection, dyslipidemia, new‐onset post‐transplant diabetes mellitus, high blood pressure, nephrotoxicity, and more seriously to the EBV‐related PTLD (2–10). The main purpose of post‐transplant surveillance is preventing rejection, optimizing long‐term graft function, and minimizing post‐transplant complications.…”
mentioning
confidence: 99%
“…Primary EBV infection occurs 1–3 months after transplantation 7,8 . In the present study, recipients in the R(−) group had leukocyte‐associated viremia between 30 and 180 days after transplantation, and these patients developed seroconversion between 43 and 266 days after transplantation.…”
Section: Discussionmentioning
confidence: 47%
“…1). Maximum EBV genome load >100 copies/μg DNA was observed in all patients in the R(−) group and in five of 14 patients in the R(+) group (seropositive normal children had <100 copies/μg DNA; data not shown), while maximum EBV genome load >400 copies/μg DNA, which was described to be ‘positive’ genome number by Hadou et al , 7 was detected in four of seven patients in the R(−) group and in four of 14 patients in the R(+) group, but all patients in the R(+) group had a maximum EBV genome load <600 copies/μg DNA (Table 1; Fig. 1[link]).…”
Section: Resultsmentioning
confidence: 69%
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“…EBV infection has been shown to have a strong association with benign mesenchymal tumours and mesenchymal de‐differentiation of malignant tumours, especially in the immunocompromised patient [6,7]. The importance of this immunocompromised state was also not sufficiently highlighted by the authors.…”
mentioning
confidence: 99%