Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome

Avar, Markus; Jordan, Jens; Neuburger, M.; Engesser, Diana; Lübke, Jan; Anton, Alexandra; Wecker, Thomas

doi:10.1007/s00417-019-04259-5

Cited by 24 publications

(25 citation statements)

References 22 publications

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“…It has been reported that thin CCT, simultaneous cataract surgery, no history of SLT, elderly status, good visual field results, and pseudo-exfoliation glaucoma are factors for better outcomes. [7][8][9][10][11][12] In the present study, the patients' preoperative IOP was not a factor influencing the surgical outcomes. Simultaneous cataract surgery was reported to be associated with better surgical outcomes in several studies.…”

Section: Discussionmentioning

confidence: 50%

<p>The Outcomes of Trabectome Surgery in Patients with Low, Middle, and High Preoperative Intraocular Pressure</p>

Tojo¹,

Hayashi²

2020

OPTH

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Background: We compared the efficiency of trabectome surgery for patients with differing preoperative intraocular pressure (IOP) values in a single-facility retrospective study. We evaluated surgical outcomes based on three grades of preoperative IOP: high (hi-IOP, >26 mmHg), middle (mid-IOP, 18-26 mmHg), and low (lo-IOP, <18 mmHg). Patients and Methods: We analyzed the cases of 204 eyes that underwent trabectome surgery and were followed >2 years. We defined failure as a reduction of IOP <20% or requiring additional glaucoma surgery. We used 4 cutoff values >21, >18, >15, and >12 mmHg. Other factors that may affect surgical outcomes were also investigated: age, central corneal thickness (CCT), history of selective laser trabeculotrabculoplasty (SLT), preoperative visual field, and simultaneous cataract surgery. Results: Trabectome surgeries significantly decreased the IOP values from 23.0 ± 7.2 mmHg to 13.6 ± 3.6 mmHg at 2 years post-surgery. The mid-IOP group achieved significantly better surgical outcomes than the lo-IOP and hi-IOP groups with cutoff values 21, 18, and 15 mmHg. A thin CCT and simultaneous cataract surgery were significantly related to better surgical outcomes with cutoff value 21.18 and 15 mmHg. Conclusion: For the patients with preoperative IOP <18 mmHg, it was difficult to decrease their IOP >20% with trabectome surgery. Patients with preoperative IOP values >26 mmHg often required additional glaucoma surgery.

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Section: Discussionmentioning

confidence: 50%

<p>The Outcomes of Trabectome Surgery in Patients with Low, Middle, and High Preoperative Intraocular Pressure</p>

Tojo¹,

Hayashi²

2020

OPTH

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“…Reduction of IOP by pharmacological agents or surgical techniques such as trabeculectomy, non-penetrating glaucoma surgery, micro-invasive glaucoma surgery and glaucoma drainage implants have so far been the primary mode of therapy to prevent disease progression in glaucoma [ 56 ]. Minimally invasive ab-interno trabeculectomy which involves removal of the TM via an electro-ablative procedure has shown to have long-term effectiveness in lowering IOP in glaucoma patients [ 57 ]. Gene therapy methods to reduce IOP and provide neuroprotection by expression of neurotrophic factors has emerged as an alternative therapeutic option, however the major challenge for gene therapy is the multiple pathogenic mutations associated with glaucoma [ 58 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Adak

Magdalene

Deshmukh

et al. 2021

Stem Cell Rev and Rep

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Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, antiangiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases. Key words Retinal regeneration . cell replacement therapy . exosomes . mitochondrial transfer . anti-inflammatory molecules Abbreviations AMD Age-related macular degeneration ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 ACE2 Angiotensin converting enzyme 2 ADSCs Adipose tissue derived mesenchymal stem cells AMSCs Amniotic membrane derived mesenchymal stem cells APCs Antigen presenting cells ASCs Adipose tissue derived stromal cells BCL-XL B-cell lymphoma-extra-large-protein BCVA Best corrected visual acuity BDNF Brain derived neurotrophic factor BM Bruch's membrane

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“…Key statistics on mechanism of action, effectiveness, and safety profile were extracted for each type of MIGS (an overview of these findings summarised in Table 2). Analysed procedures were limited to Schlemm's canal iStent Hooshmand et al [5] Ferguson et al [6] Ferguson et al [7] Ahmed et al [8] Katz et al [9] + Hooshmand et al [5] Samuelson et al [10] + CE + CE Samuelson et al [4] Ahmed et al [8] + CE + CE Davids et al [11] Heersink et al [12] +/-CE Esfandiari et al [13] Avar et al [14] + CE +/-CE Elmallah et al [16] + CE RCS 315 eyes 12 mo: -27.47 12 mo: -1.03 Supraciliary space/ciliary process CyPass Vold et al [17] Reiss et al [18] Fard et al [19] Fard et al [19] + Myers et al [20] + 2 iStent PCS 80 subjects 48 mo: -41.36 n/a ECP Pantalon et al [21] + CE + 2 iStent PCS 63 eyes 12 mo: -34.65 12 mo: -0.98 Subconjunctival space XEN Gel Stent Olgun et al [15] Karimi et al [22] Wagner et al [23] Gillmann et al [24] +…”

Section: Description Of Included Trialsmentioning

confidence: 99%

“…Trabectome has also demonstrated efficacy in pseudoexfoliative glaucoma. Avar et al [14] investigated Trabectome performed on patients either as a solo procedure or with concomitant cataract extraction (in combined data) described a significant IOP lowering effect in 28% of patients with POAG and 26% with pseudoexfoliative glaucoma, as well as a significant medication reduction in 32% and 29%, respectively. The median follow-up period in this study was 3.5 years [14] .…”

Section: Trabectome: Mechanism Of Action and Efficacymentioning

confidence: 99%

Minimally invasive glaucoma surgery - current and emerging techniques to reduce intraocular pressure and medications

Komzak¹,

Rothschild²,

Hooshmand³

et al. 2021

Mini-invasive Surg

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Minimally invasive glaucoma surgery (MIGS) has become increasingly popular as a step in the management pathway of open angle glaucoma. Due to the relative novelty of these devices, there remains some paucity of evidence relating to their long-term efficacy and safety, and this can make comparison between these techniques somewhat complex. This review article aims to guide clinical decision making by providing the latest evidence on the comparative efficacy of current iterations of minimally invasive glaucoma surgery. A literature review was conducted to identify the most significant recent evidence to support the safety and efficacy of the various forms of minimally invasive glaucoma surgery. Included studies provided efficacy and safety data on a variety of minimally invasive glaucoma surgery methods. The PubMed database was searched and a total of 484 studies, published between 2015 and 2020 were identified, of which 27 were included. The studies indicate that most available forms of minimally invasive glaucoma surgery show statistically significant efficacy in terms of intraocular pressure reduction and improvement in medication burden, while maintaining an acceptable safety profile.

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Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome

Cited by 24 publications

References 22 publications

<p>The Outcomes of Trabectome Surgery in Patients with Low, Middle, and High Preoperative Intraocular Pressure</p>

<p>The Outcomes of Trabectome Surgery in Patients with Low, Middle, and High Preoperative Intraocular Pressure</p>

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Minimally invasive glaucoma surgery - current and emerging techniques to reduce intraocular pressure and medications

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