Long-term follow-up of neurosarcoidosis

Ferriby, D.; Sèze, Jérôme De; Stojkovic, T.; Hachulla, É.; Wallaert, B.; Destée, Alain; Hatron, Pierre‐Yves; Vermersch, P.

doi:10.1212/wnl.57.5.927

Cited by 109 publications

(70 citation statements)

References 5 publications

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“…A systemic involvement may not be a predictive factor for the evolution of neurosarcoidosis. These data further conform the previously reported cases of Ferriby et al (6). This warrants further multicenter prospective studies to evaluate the clinical course in more definite way.…”

Section: Discussionsupporting

confidence: 92%

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Diabetes Insipidus from Neurosarcoidosis: Long-term Follow-up for More than Eight Years

et al. 2004

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Section: Discussionsupporting

confidence: 92%

“…Facial palsy is an early manifestation of neurosarcoidosis but it is unclear whether diabetes insipidus occurs early or late in the course of the disease since long-term follow-up of such patients are rarely reported (5)(6)(7). We present a longterm clinical outcome of 4 cases of neurosarcoidosis with diabetes insipidus (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Diabetes Insipidus from Neurosarcoidosis: Long-term Follow-up for More than Eight Years

et al. 2004

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“…This suggestion can also be applied to polyradiculopathy in sarcoidosis. As pointed out by Ferriby et al recently, the majority patients with isolated neurological involvement at the beginning of sarcoidosis show one or more extra-neurological symptoms during the long-term follow-up (15). This was true also in the present patient.…”

Section: Discussionsupporting

confidence: 85%

"A Girdle-like Tightening Sensation" Misapprehended as Abdominal Splanchnopathy in a Sarcoidosis Patient

et al. 2005

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We describe a 53-year-old man with the isolated manifestation of girdle-like tightening sensation of the trunk due to polyradiculopathy at the beginning of sarcoidosis which was first misapprehended as abdominal splanchnopathy. Late development of other neurological and systemic symptoms led to the final diagnosis of sarcoidosis. Segmental dysesthesia at the trunk in neurosarcoidosis is unique and may mimic a splanchnic pain.

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“…Neurological symptoms are the primary manifestation of the disease in 62-74% of cases of NS (ref. 2,3 ). Majority of patients with NS develop systemic symptoms after presenting neurological signs of disease.…”

Section: Introductionmentioning

confidence: 99%

Neurosarcoidosis: Two case reports with multiple cranial nerve involvement and review of the literature

Mijajlović¹,

Mirkovic²,

Mihailović-Vučinić³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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aBackground. Involvement of the central nervous system is registered in a relatively small number of patients with sarcoidosis. In this article we present two cases with various neurological symptoms that fulfill criteria for neurosarcoidosis (NS). In addition, we review the literature on NS with special attention to isolated cranial nerve involvement. Methods and Results. First patient: Neurological examination identified multiple cranial neuropathy, moderate rightsided hemiparesis, polyradiculoneuritis of the lower limbs and positive meningeal signs. Laboratory tests showed serum and cerebrospinal fluid (CSF) inflammatory abnormalities, with increased values of the angiotensin-converting enzyme (ACE). CSF analysis also showed presence of 9 oligoclonal IgG bands. Brain and spine magnetic resonance imaging (MRI) revealed diffuse meningopathy, and focal granulomatous lesion in the body of the L5 vertebra. Lung sarcoidosis was confirmed by additional diagnostic procedures. The patient was treated with Methylprednisolone and a tapering course of oral Prednisone, which reduced the pain in the back and legs and improved the strength of the right leg. However, the other neurological deficiencies remained. After confirming lung sarcoidosis, the patient received Methotrexate in addition to Prednisone but during the following 2 years the patient's condition progressively worsened and ended in death. Second patient: Neurological findings showed weakness of the right n. oculomotorius and the right n. trochlearis, as well as the right-side face weakness. We found raised level of the ACE in serum and CSF. Thorax high-definition computed tomography (HDCTT) showed ribbon-like domains of discrete changes in the pulmonary parenchyma. MRI of the brain showed multiple white matter lesions. This patient also received Methylprednisolone followed by Prednisone, and after two months, ocular motility normalized. Conclusion. The diagnosis of NS is always a challenge. For this rerason definitive diagnosis requires the exclusion of other causes of neuropathy. Multiple cranial neuropathies should always arouse suspicion of NS.

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Long-term follow-up of neurosarcoidosis

Cited by 109 publications

References 5 publications

Diabetes Insipidus from Neurosarcoidosis: Long-term Follow-up for More than Eight Years

Diabetes Insipidus from Neurosarcoidosis: Long-term Follow-up for More than Eight Years

"A Girdle-like Tightening Sensation" Misapprehended as Abdominal Splanchnopathy in a Sarcoidosis Patient

Neurosarcoidosis: Two case reports with multiple cranial nerve involvement and review of the literature

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