Long-term Follow-up of Non-A, Non-B (Type C) Post-transfusion Hepatitis

Tremolada, F.; Casarin, Carla; Alberti, Alberto; Drago, Claudio; Tagger, A.; Ribero, Maria Luisa; Realdi, G.

doi:10.1097/00132586-199310000-00028

Cited by 63 publications

(89 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Progressive liver disease was found in 50% of these individuals and 20% had liver cirrhosis. This rate of progression is in contrast to some previous reports7 11 27 but consistent with data from Tremolada and colleagues8 and Tong and colleagues 9…”

Section: Discussionsupporting

confidence: 92%

“…4 Chronic HCV infection can run a mild course with little or no morbidity but the long term sequelae have been found to differ widely in different studies 5-11. Progression to cirrhosis will occur in up to 30% of all cases5-8 and the risk of developing hepatocellular carcinoma (HCC) after longstanding infection is clearly increased 812 13 The reason why some people and not others develop severe disease may be determined by the effect of a large number of both host and viral variables that can influence disease progression.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre

Datz

Cramp

Haas

et al. 1999

Gut

View full text Add to dashboard Cite

Background-The natural history of hepatitis C virus (HCV) infection is variable and factors determining the course of the illness are unclear.Aims-To determine the natural course of HCV infection in a well characterised group of patients 18 years after an epidemic outbreak of non-A, non-B hepatitis at a plasmapheresis centre. Methods-Between 1994 and 1996, 20 of 30 aVected individuals were studied. HCV infection was confirmed using second and third generation ELISA test kits. HCV RNA was detected by a polymerase chain reaction (PCR) method and HCV genotyping was performed by analysing amplicons from the conserved 5'-nontranslated region generated by nested PCR. Thirty two liver biopsies were carried out in 14 patients. Results-HCV antibodies were detected in all subjects. Eighteen patients had abnormal liver enzymes and 17 were HCV RNA positive, all of whom were infected with genotype 1a. Ninety per cent of this cohort showed evidence of chronic HCV infection with 50% having progressive liver disease and 20% cirrhosis 18 years after acute onset of non-A, non-B hepatitis. Considerable variation in disease outcome occurred between individuals and no correlation with clinical features of the acute illness was found. Conclusions-Variability in the consequences of HCV infection in cases infected with the same virus suggests that host factors are important in determining disease outcome. The factors which determine diVerences in the natural history of the disease still remain to be elucidated.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre

Datz

Cramp

Haas

et al. 1999

Gut

View full text Add to dashboard Cite

show abstract

“…We modified the front end of the model to include patients with normal alanine aminotransferase (ALT) levels and chronic HCV infection, adding the assumption of non-progression of the disease for these patients. Table 1 shows the probabilities of transition between each state [4,[6][7][8][9][10][11][12][13][14][15][16][17][18]. The model was validated by predicting the 5-year survival rate of a cohort of patients with compensated cirrhosis.…”

Section: Decision Analytic Model: Markov Modelmentioning

confidence: 99%

Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C

Buti

Miguel

Brosa³

et al. 2005

Journal of Hepatology

101

View full text Add to dashboard Cite

“…More than 10 years after the discovery of HCV, however, some aspects of the natural history of hepatitis C remain unclear, and there is a need to reconcile the indolent or slowly progressive disease reported in many prospective studies with the well-documented serious outcomes, such as cirrhosis and hepatocellular carcinoma, observed in tertiary-care centers [1][2][3][4][5][6][7][8]. The varying rates of progression of HCV infection to cirrhosis are thought to be the effect of both host-and virus-associated variables, but the long duration of the disease and the fact that many patients have been treated have made prospective studies difficult.…”

mentioning

confidence: 99%

Chronic Hepatitis C Virus Infection in Childhood: Clinical Patterns and Evolution in 224 White Children

Resti²,

et al. 2003

View full text Add to dashboard Cite

The characteristics and evolution of hepatitis C virus (HCV) infection were retrospectively investigated in a study of 224 HCV RNA-seropositive white children who were consecutively recruited at 7 European centers in 1980-1998. At presentation, all patients were positive for antibodies to hepatitis C virus, 87% were asymptomatic, and 48% had alanine aminotransferase (ALT) levels that were < or =2 times the upper limit of the range considered to be normal. Of 200 children followed for 1-17.5 years (mean follow-up +/- standard deviation [SD], 6.2+/-4.7 years), only 12 (6%) achieved sustained viremia clearance and normalization of the ALT level. In 92 revised liver biopsy specimen analyses, the mean fibrosis score (+/-SD) was 1.5+/-1.3 for children <15 years of age and 2.3+/-1.2 for children > or =15 years of age (range, 0-6 years; P<.01). Pediatric HCV infection is usually mild, but few patients, especially those who are perinatally infected, clear viremia in the medium-term follow-up. Conversely, the higher rates of fibrosis observed in older patients suggest the possibility of an insidious progression of HCV-associated liver disease.

show abstract

Long-term Follow-up of Non-A, Non-B (Type C) Post-transfusion Hepatitis

Cited by 63 publications

References 0 publications

The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre

The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre

Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C

Chronic Hepatitis C Virus Infection in Childhood: Clinical Patterns and Evolution in 224 White Children

Contact Info

Product

Resources

About