Long term follow-up of Parkinson's disease patients with impulse control disorders

Sohtaoğlu, Melis; Demiray, Derya Yavuz; Kenangil, Gülay; Özekmekçi, Sibel; Erginöz, Ethem

doi:10.1016/j.parkreldis.2010.02.006

Cited by 43 publications

(40 citation statements)

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“…(2011) in Spain, 72.7% over 43.2 months by Sohtaoglu et al. (2010) in Turkey to 73.3% over 29.2 months by Mamikonyan et al. (2008) in the United States.…”

Section: Discussionmentioning

confidence: 91%

“…Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM‐IV) and criteria of their own by Sohtaoglu et al. (2010)), Voon and Fox's criteria by Avila et al. (2011) and Siri et al (2015).…”

Section: Discussionmentioning

confidence: 98%

“…A number of cross‐sectional studies of ICB in PD have been conducted, but longitudinal assessments have been less reported (Antonini et al., 2017; Avila, Cardona, Martin‐Baranera, Bello, & Sastre, 2011; Bastiaens, Dorfman, Christos, & Nirenberg, 2013; Mamikonyan et al., 2008; Siri et al., 2015; Smith, Xie, & Weintraub, 2016; Sohtaoglu, Demiray, Kenangil, Ozekmekci, & Erginoz, 2010) and little is known about the course or change in ICB according to the type of medication. ICBs are not permanent symptoms and can go into remission (Avila et al., 2011; Mamikonyan et al., 2008; Siri et al., 2015; Sohtaoglu et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

“…ICBs are not permanent symptoms and can go into remission (Avila et al., 2011; Mamikonyan et al., 2008; Siri et al., 2015; Sohtaoglu et al., 2010). In previous studies, the ICB remission ratio in PD was reported to be 40% during 3.5 years of follow‐up period (Siri et al., 2015) to 73.3% over 29.2 months (Mamikonyan et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies, the ICB remission ratio in PD was reported to be 40% during 3.5 years of follow‐up period (Siri et al., 2015) to 73.3% over 29.2 months (Mamikonyan et al., 2008). The factors associated with ICB remission were reduction in DA use (Avila et al., 2011), lower DA dosage (Mamikonyan et al., 2008; Sohtaoglu et al., 2010), and better working memory performance (Bastiaens et al., 2013). However, the reduction or discontinuation of DA may induce DA withdrawal symptoms and worsen motor symptoms, meaning that formulating a treatment strategy for ICB is problematic (Weintraub et al., 2015; Zurowski & O'Brien, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The factors associated with impulse control behaviors in Parkinson's disease: A 2‐year longitudinal retrospective cohort study

et al. 2018

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IntroductionImpulse control behaviors (ICBs) are impulsive–compulsive behaviors often associated with dopamine replacement therapy in Parkinson's disease (PD). Although remission can occur in ICB, only four reports on the ratio of remission and the persistence of ICB have been published, and the associated factors with ICB remission or persistence have been little known. Therefore, we conducted a longitudinal assessment of the remission, persistence, and development of ICB and those associated factors in patients with PD.MethodsWe retrospectively investigated a PD database at Aomori Prefectural Central Hospital, Japan. One hundred and forty‐eight patients with PD who could be followed up for 2 years were enrolled. ICB was assessed using the Questionnaire for Impulsive–Compulsive Disorders in Parkinson's disease. Motor severity (Hoehn and Yahr scale and United Parkinson's Disease Rating Scale), cognitive function (Mini–Mental State Examination), and other clinical variables (sex, age, onset age, disease duration, olfactory dysfunction, and dyskinesia) and medications used to treat PD were assessed. Univariate analyses were performed.ResultsSeven patients were excluded because of the exclusion criteria, and 141 patients were analyzed. Thirty patients (21.3%) had ICB at baseline, and these patients also had significantly higher use of pergolide. The ICB remission rate was 60%, the ICB persistence ratio was 40%, and the ICB development ratio was 12.6% over 2 years. Statistically, younger age and pergolide use were associated with ICB persistence. Being male, having dyskinesia, and rotigotine, entacapone, zonisamide, and istradefylline use were associated with ICB development.ConclusionThis study suggests that younger age and pergolide use may be the new associated factors with ICB persistence and that entacapone, zonisamide, and istradefylline use may be associated with the development of ICB. Drug profiles and medication practices in Japan may explain the association of these factors with ICB.

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“…(2011) in Spain, 72.7% over 43.2 months by Sohtaoglu et al. (2010) in Turkey to 73.3% over 29.2 months by Mamikonyan et al. (2008) in the United States.…”

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The factors associated with impulse control behaviors in Parkinson's disease: A 2‐year longitudinal retrospective cohort study

et al. 2018

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Hypersexuality in Parkinson's Disease: Systematic Review and Report of 7 New Cases

Codling

Shaw

David

2015

Movement Disord Clin Pract

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Hypersexuality (HS) was one of the earliest examples of an impulse control disorder (ICD) or behavior to be associated with treatment for Parkinson's disease (PD), with an estimated prevalence of approximately 3.5%. Here, we report on a systematic review of the published literature of HS in PD with a view to uncovering evidence as to whether it is distinct from other ICDs. In addition, we report on 7 new cases that had broad neuropsychological testing, including a gambling test, which taps into reward and inhibitory mechanisms. The review uncovered a number of case series and cohorts that comment on the prevalence of HS, but very few made systematic comparisons with other ICDs, although younger onset and male sex are usually noted. A few studies have begun to map out a neuropsychological profile for HS, and our own cases show particular deficits in learning from negative outcomes, but, overall, there are insufficient data to draw firm conclusions. Functional imaging has shown patterns of increased content-specific activation in response to sexual material and this might relate to increased dopamine release. We conclude with a brief survey of the neurobiology of sexuality, which suggests possible avenues for further research and treatment of HS.

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Bupropion abates dopamine agonist-mediated compulsive behaviors in Parkinson's disease

Benincasa¹,

Pellicano²,

Fanciulli³

et al. 2010

Mov. Disord.

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Long term follow-up of Parkinson's disease patients with impulse control disorders

Cited by 43 publications

References 27 publications

The factors associated with impulse control behaviors in Parkinson's disease: A 2‐year longitudinal retrospective cohort study

The factors associated with impulse control behaviors in Parkinson's disease: A 2‐year longitudinal retrospective cohort study

Hypersexuality in Parkinson's Disease: Systematic Review and Report of 7 New Cases

Bupropion abates dopamine agonist-mediated compulsive behaviors in Parkinson's disease

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