Long-term follow-up of patients undergoing auto-SCT for advanced germ cell tumour: a multicentre cohort study

Seftel, M.D.; Paulson, Kristjan; Doocey, Richard; Song, Kevin; Czaykowski, Piotr; Coppin, Chris; Forrest, Daniel L.; Hogge, Donna E.; Kollmansberger, Christian K.; Smith, Colin; Shepherd, John; Toze, Cynthia L.; Murray, Nevin; Sutherland, Heather J.; Nantel, SH; Tj, Nevill; Barnett, Michael J.

doi:10.1038/bmt.2010.250

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…For patients with relapsed GCT following initial cisplatin-based chemotherapy, the optimal salvage chemotherapy regimen is still being debated. According to this Canadian survey study, the use of salvage HDCT and ASCT was favored over CDCT in the first line salvage setting upon relapse following initial cisplatin-based chemotherapy, which is consistent with previous data [9]. The IPFSG criteria was used by about a third of oncologists surveyed to select CDCT for IPFSG very low risk and/or low risk patients., and 17% surveyed were in fact not familiar with this prognostic score.…”

Section: Discussionsupporting

confidence: 85%

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

et al. 2023

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Background: Although metastatic germ cell tumor (GCT) is highly curable with initial cisplatin-based chemotherapy (CT), 20–30% of patients relapse. Salvage CT options include conventional (CDCT) and high dose chemotherapy (HDCT), however definitive comparative data remain lacking. We aimed to characterize the contemporary practice patterns of salvage CT across Canada. Methods: We conducted a 30-question online survey for Canadian medical and hematological oncologists with experience in treating GCT, assessing treatment availability, patient selection, and management strategies used for relapsed GCT patients. Results: There were 30 respondents from 18 cancer centers across eight provinces. The most common CDCT regimens used were TIP (64%) and VIP (25%). HDCT was available in 13 centers (70%). The HDCT regimen used included carboplatin and etoposide for two cycles (76% in 7 centers), three cycles (6% in 2 centers), and the TICE protocol (11%, in 2 centers). “Bridging” CDCT was used by 65% of respondents. Post-HDCT treatments considered include surgical resection for residual disease (87.5%), maintenance etoposide (6.3%), and surveillance only (6.3%). Conclusions: HDCT is the most commonly used GCT salvage strategy in Canada. Significant differences exist in the treatment availability, selection, and delivery of HDCT, highlighting the need for standardization of care for patients with relapsed testicular GCT.

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Section: Discussionsupporting

confidence: 85%

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

et al. 2023

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The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

Al-Ezzi¹,

Zahralliyali²,

Hansen³

et al. 2023

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Background: Although metastatic GCT is highly curable with initial cisplatin-based chemotherapy (CT), 20-30% of patients relapse. Salvage CT options include conventional (CDCT) and high dose chemotherapy (HDCT), however definitive comparative data remains lacking. We aimed to characterize the contemporary practice patterns of salvage CT across Canada. Methods: We conducted a 30-question online survey for Canadian medical and hematological oncologists with experience in treating GCT, assessing treatment availability, patient selection, and management strategies used for relapsed GCT patients. Results: Respondents included 30 staff; from 18 cancer centers across provinces. The most common CDCT regimens used were TIP (64%) and VIP (25%). HDCT was available for (70%) in 13 centers. HDCT regimen used included carboplatin and etoposide for 2 cycles (76% in 7 centers), 3 cycles (6% in two centers), and the TICE protocol (11%, in 2 centers). “Bridging” CDCT was used by 65% respondents. Post HDCT treatments considered include surgical resection for residual disease (87.5%), maintenance etoposide (6.3%) and sur-veillance only (6.3%). Conclusions: HDCT is the most commonly used GCT salvage strategy in Canada. Significant differences exist in the treatment availability, selection and delivery of HDCT, highlighting the need for standardization of care for patients with relapsed testicular GCT.

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Long-term follow-up of patients undergoing auto-SCT for advanced germ cell tumour: a multicentre cohort study

Cited by 2 publications

References 26 publications

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

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