Long term follow-up of retinal nerve fiber layer thickness in eyes with optic nerve head drusen

Ocakoğlu, Özcan; Ustundag, Can; Koyluoglu, Nilufer; Oğuz, Velittin; Kendiroğlu, Gürhan; Özkan, Şehirbay

doi:10.1076/ceyr.26.4.277.15428

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…Subsequent studies yielded the same results [32][33][34]. Unsurprisingly, the current study shows that these two quadrants have a significantly decreased thickness when compared with control eyes, whereas we found no significant difference in the nasal or temporal sectors.…”

Section: Discussionsupporting

confidence: 84%

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Casado

Rebolleda

Guerrero

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionsupporting

confidence: 84%

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Casado

Rebolleda

Guerrero

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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“…16; 32; 48; 62; 74; 88; 92; 103; 141; 153; 154; 158; 170; 201 In a study of OCT RNFL in children with optic disc drusen, Noval et al found the RNFL thickness to be higher than controls in eyes with partially or completely buried drusen and lower than controls in eyes with superficial drusen. 152 The RNFL defect is typically nasal, with sparing of the temporal RNFL.…”

Section: Diagnostic Testingmentioning

confidence: 99%

Optic disk drusen in children

Chang

Pineles

2016

Survey of Ophthalmology

112

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Optic disc drusen occur in 0.4% of children and consist of acellular intracellular and extracellular deposits that often become calcified over time. They are typically buried early in life and generally become superficial, and therefore visible, later in childhood, at the average age of 12 years. Their main clinical significance lies in the ability of optic disc drusen, particularly when buried, to simulate true optic disc edema. Misdiagnosing drusen as true disc edema may lead to an invasive and unnecessary workup for elevated intracranial pressure. Ancillary testing, including ultrasonography, fluorescein angiography, fundus autofluorescence, and optical coherence tomography, may aid in the correct diagnosis of optic disc drusen. Complications of optic disc drusen in children include visual field defects, hemorrhages, choroidal neovascular membrane, non-arteritic anterior ischemic optic neuropathy, and retinal vascular occlusions. Treatment options for these complications include ocular hypotensive agents for visual field defects and intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents for choroidal neovascular membranes. In most cases, however, children with optic disc drusen can be managed by observation with serial examinations and visual field testing, once true optic disc edema has been excluded.

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“…Since Huang et al first described the technology of optical coherence tomography (OCT) over 15 years ago,22 OCT has become a widely-used technology in ophthalmology 3,12,15,16,20. The leading current commercially available OCT machine (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…All of these techniques, however, can only assess if ONHD are present or not; however there is little or no information on the exact shape, size or location of the drusen. Although time domain optical coherence tomography (OCT; StratusOCT, Carl Zeiss Meditec, Dublin, CA) studies have shown not only retinal nerve fiber layer (RNFL) thinning but also documentation of scleral canal size in ONHD patients,7,8,10,15,16 this imaging modality still can not determine exact ONHD size, shape or location, which would be useful when trying to determine if progressive visual field loss is from ONHD or glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Imaging of Optic Nerve Head Drusen

Yi¹,

Mujat²,

Sun³

et al. 2009

Journal of Glaucoma

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Objective-To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD) which were imaged with spectral domain optical coherence tomography (SDOCT).Methods-One exenteration patient and four glaucoma patients with bilateral ONHD were recruited from the Massachusetts Eye and Ear Infirmary and from a private practice office. Images were obtained using an experimental SDOCT system developed at the Wellman Center for Photomedicine, Massachusetts General Hospital. With axial resolutions of about 6 μm, SDOCT can obtain 2-dimensional images in 1/29 of a second, compared to commercially available time domain OCT instruments with 10 μm resolution images in 1.28 seconds. The volumes of ONHD were calculated with a new algorithm and were then correlated with visual field mean deviation.Results-SDOCT can display two-dimensional images comparable to histology as well as 3-dimensional videos of ONHD. ONHD are signal-poor regions with high-signaled borders. Larger ONHD volumes are directly correlated with larger mean deviation absolute values on Humphrey visual field testing.Conclusions-SDOCT is a potentially better technique for ONHD imaging and may improve the diagnosis and management of patients with both OHND and glaucoma.

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Long term follow-up of retinal nerve fiber layer thickness in eyes with optic nerve head drusen

Abstract: The presence of drusen was found to have no effect on RNFL thickness at follow-up visits. OCT may provide a useful means to evaluate and follow up the RNFL thickness in these patients.

Cited by 18 publications

References 15 publications

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Optic disk drusen in children

Imaging of Optic Nerve Head Drusen

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