Long-Term Follow-up Results in Children and Adolescents Treated with Radioactive Iodine (<sup>131</sup>I) for Hyperthyroidism

Safa, Ali M.; Schumacher, O. Peter; Rodríguez-Antúnez, Antonio

doi:10.1056/nejm197501232920401

Cited by 170 publications

(53 citation statements)

References 43 publications

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“…It occurs in 20 -40% of children in the first year after treatment and 2-3% per year thereafter; thus, most children eventually become hypothyroid (63). In a very recent study, Rivkees and Cornelius (69) examined the relationship between the dose of iodine-131 in children with hyperthyroidism and thyroid status 1 year after treatment.…”

Section: Overall Toxicity (%)mentioning

confidence: 99%

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Krassas¹

2004

European Journal of Endocrinology

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Section: Overall Toxicity (%)mentioning

confidence: 99%

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Krassas¹

2004

European Journal of Endocrinology

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“…РЙТ применялась для лечения диффуз-ного токсического зоба у детей начиная с одно летнего возраста с превосходным ре-зультатом [20].…”

Section: ключевые слова: радиойодтерапия дети подростки болезнь грunclassified

“…Эмпирический опыт, накопленный дли-тельным применением РЙТ у детей, свиде-лечения РЩЖ регистрируется в процессе аналогичного по длительности периода на-блюдения в 0,4-2,5% случаев [20]. Ни у од-ного из пациентов в процессе наблюдения не выявлено случаев лейкемии или каких-ли-бо карцином, как не было проблем с реали-зацией репродуктивной функции и врожден-ной патологии у родившихся у них детей [20].…”

Section: ключевые слова: радиойодтерапия дети подростки болезнь грunclassified

Radioiodine therapy of thyrotoxicosis in children and adolescents. Indications, efficacy and safety. Literature review

et al. 2016

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Болезнь Грейвса (БГ) – основная причина тиреотоксикоза у детей. В современной клинической практике применяется три метода лечения БГ: тиреостатики, радиоактивный йод и операция. Все эти методы лечения применяются давно, и в мире накоплен огромный опыт применения каждого из методов лечения. Лечение начинают практически всегда с тиреостатиков, непереносимость или неэффективность которых становится показанием к выбору альтернативных методов лечения. Для осознанного выбора метода лечения необходимо понимать его потенциальные параметры эффективности и безопасности, а также влияющие на них факторы. Цель обзора – критический анализ эффективности и безопасности радиойодтерапии в лечении тиреотоксикоза у детей и подростков в сравнении с аналогичными показателями других методов лечения, а также показания и противопоказания к данному виду лечения в современной клинической практике эндокринологов, радиологов и эндокринных хирургов. Выбор тактики лечения БГ у ребенка на каждом этапе осуществляется согласованно с ним и его родителями/опекунами путем информирования лечащим врачом об объективных преимуществах и недостатках методов лечения на основе имеющейся доказательной базы. Также приведены основные рекомендации эффективной и безопасной терапии радиоактивным йодом БГ у детей и подростков.

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“…Existem poucos relatos na literatura sobre o uso do I 1 3 1 em crianças muito jovens, sendo a mais jovem com 1 ano de idade (31). Estudos após o acidente nuclear de Chernobyl mostraram que o câncer de tireóide ocorreu em maior número em crianças que tinham menos de 1 ano de idade (32).…”

Section: Tratamento Com Iodo Radioativounclassified

Utilização do 131I no tratamento da doença de Basedow-Graves na infância e adolescência

Monte

Calliari

Longui

2004

Arq Bras Endocrinol Metab

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RESUMOEmbora o diagnóstico da Doença de Graves (DG) na infância e adolescência seja relativamente fácil, seu tratamento ainda é controverso. Pode-se utilizar fármacos anti-tireoideanos (MMZ ou PTU), porém a incidência de efeitos adversos nessa faixa etária é maior que nos adultos e a taxa de remissão é baixa, mesmo com o uso prolongado. A cirurgia é pouco indicada como tratamento inicial, sendo realizada mais freqüentemente após recidiva do tratamento medicamentoso e/ou devido aos seus efeitos adversos. A utilização da radioiodoterapia na infân-cia e adolescência vem crescendo. Com doses adequadas, ocorre o desenvolvimento de hipotireoidismo em cerca de 90% dos casos num período de 3 a 6 meses. Os dados iniciais sugerem que o tratamento em crianças acima de 5 anos não parece estar associado a maior risco de carcinoma de tireóide. A prevalência de efeitos adversos é menor que na cirurgia. Pacientes que apresentam fatores clínicos ou laboratoriais de pior prognóstico evolutivo podem ter seu tratamento medicamentoso encurtado, sendo a indicação da radioiodoterapia realizada mais precocemente. While the diagnosis of Graves' disease in childhood and adolescence is relatively straightforward, its treatment remains controversial. The first choice therapy is the use of anti-thyroid drugs, although side effects are more frequent than in adults and remission is low. Surgery is not usually indicated as initial treatment. Instead, it is generally recommended after recidive of the disease or due to side effects of medical treatment. The use of radioiodine therapy is increasing in this age group, especially in North America, and control of the hyperthyroidism is achieved in 3 to 6 months in 90% of the cases. There is no evidence that radioiodine therapy is associated with a higher risk of thyroid cancer, and the occurrence of side effects is lower than surgery. Based on the positive results obtained with this therapy, patients with poor responsiveness to medical treatment should be considered for early radioiodine therapy. lescência, sendo que apenas 1 a 5% dos pacientes afetados estão compreendidos nessa faixa etária (1). Porém, a DG, uma doença autoimune caracterizada por apresentar bócio difuso, hipertireoidismo e oftalmopatia, é a revisão

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Long-Term Follow-up Results in Children and Adolescents Treated with Radioactive Iodine (¹³¹I) for Hyperthyroidism

Cited by 170 publications

References 43 publications

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Radioiodine therapy of thyrotoxicosis in children and adolescents. Indications, efficacy and safety. Literature review

Utilização do 131I no tratamento da doença de Basedow-Graves na infância e adolescência

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Long-Term Follow-up Results in Children and Adolescents Treated with Radioactive Iodine (131I) for Hyperthyroidism

Cited by 170 publications

References 43 publications

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Treatment of juvenile Graves' disease and its ophthalmic complication: the 'European way'

Radioiodine therapy of thyrotoxicosis in children and adolescents. Indications, efficacy and safety. Literature review

Utilização do 131I no tratamento da doença de Basedow-Graves na infância e adolescência

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Long-Term Follow-up Results in Children and Adolescents Treated with Radioactive Iodine (¹³¹I) for Hyperthyroidism