Long-term functional and anatomical results of osteo- and osteoodonto-keratoprosthesis

Michael, Ralph; Charoenrook, Víctor; Paz, María Fidéliz de la; Hitzl, Wolfgang; Temprano, José; Barraquer, Rafael I.

doi:10.1007/s00417-008-0850-3

Cited by 59 publications

(24 citation statements)

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“…[20][21][22][23][24][25][26][27] Direct comparisons of the Boston keratoprosthesis implantation (type I or II) with MOOKP implantation in eyes with MMP are limited by the small number (,5) of MMP eyes included in most reports, 22,23,25,26 and in some cases, comparisons are limited by the lack of classification of outcomes by preoperative diagnosis. 21,24 Only 2 studies report the best-corrected visual acuity and anatomic retention of the MOOKP device over the long term. 20,27 By Kaplan-Meier survival analysis, De La Paz et al 27 reported retention of visual acuity of 20/400 or better 2 years after MOOKP implantation at approximately 40% for 8 eyes with MMP.…”

Section: Discussionmentioning

confidence: 98%

The Boston Keratoprosthesis Type I in Mucous Membrane Pemphigoid

Palioura

Kim

Dohlman

et al. 2013

Cornea

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Section: Discussionmentioning

confidence: 98%

The Boston Keratoprosthesis Type I in Mucous Membrane Pemphigoid

Palioura

Kim

Dohlman

et al. 2013

Cornea

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“…1 In such circumstances, the use of an artificial cornea, or keratoprosthesis (Kpro), plays a significant role in providing visual rehabilitation. Many Kpro devices have been developed over the past decades, including AlphaCor, 2,3 Boston Keratoprosthesis (Boston Kpro), 4 osteo-odonto keratoprosthesis (OOKP), 5 and the Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis.…”

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confidence: 99%

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt

Tan

Thompson

Konstantopoulos

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Synthetic keratoprostheses are required for visual rehabilitation in patients with endstage corneal blindness. This study aimed to assess the biocompatibility of graphene material and its potential as a novel synthetic keratoprosthesis skirt material for corneal tissue engineering. METHODS.Human corneal stromal fibroblasts were cultured on material surfaces including pristine graphene film, graphene foam, pristine titanium (Ti) discs, and tissue culture plastic surface (TCPS). Cell attachment was assayed by immunostaining of paxillin and vinculin. Cell viability and proliferation were assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and Click iT 5-ethynyl-2 0 -deoxyuridine (EdU) assays. The growth of fibroblasts on three-dimensional graphene foam was examined by scanning electron microscopy, and cytokine release was analyzed by enzyme-linked immunosorbent assay. Graphene films were implanted into rabbit corneal stromal pockets and examined by slit-lamp biomicroscopy, anterior segment optical coherence tomography, in vivo confocal microscopy, and histology.RESULTS. Pristine graphene demonstrated good biocompatibility with human stromal fibroblasts in terms of cell adhesion, viability, and proliferation. Cells on graphene films showed higher number than on TCPS control. Cells grown on graphene had 10% more proliferation than on Ti. The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film. Implantation of graphene film into rabbit stroma (n ¼ 6) did not show any signs of infection, neovascularization, or inflammation.CONCLUSIONS. Graphene displayed excellent short-term biocompatibility with corneal cells and tissue. This demonstrates that graphene can be developed as a tissue engineering material for use in cornea.

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“…Eyes with compromised ocular surface but with preserved wetness are amenable to the most commonly used Boston type I keratoprosthesis 1–4. For severe dry eyes with keratinised ocular surface, available options include Pintucchi (dacron-felt) keratoprosthesis,5 6 Temprano (osteo) keratoprosthesis,7 Boston type II keratoprosthesis8–10 and modified osteo-odonto keratoprosthesis11 12 (MOOKP) each having its own potential benefits as well as limitations 13…”

Section: Introductionmentioning

confidence: 99%