Long term functional outcome evaluation in post flexor digitorum profundus tendon zone I rupture repaired by palmaris longus tendon grafting augmented with human amniotic membranes and adipose derived mesenchymal stem cell: A case report

Suroto, Heri; Satmoko, Benedictus Anindita; Rarasati, Twindy; Prajasari, Tabita

doi:10.1016/j.ijscr.2023.107960

Cited by 1 publication

(1 citation statement)

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“…ASCs have also been shown to decrease the expression of in ammatory factors such as IL-1β, GLUT1, and CA9 in mice during the early stages of tendon injury, while inducing neovascularization [11]. The combination of human amniotic membrane (HAM) with ASCs further enhances anti-adhesion properties and accelerates tendon healing [12]. Umbilical cordderived MSCs (UC-MSCs) exhibit greater proliferative and self-renewal potential [13] and can induce tendon regeneration at macroscopic, histological, and biomechanical levels [14].…”

Section: Introductionmentioning

confidence: 99%

Human Umbilical Cord Mesenchymal Stem Cells promote tendon functional repair in a Collagenase-Induced Tendinopathy Model

Sun,

Lin,

Chen

et al. 2024

Preprint

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Achilles tendon rupture is a common tendinopathy.We investigated the therapeutic effects of UC-MSCs on the inflammatory condition, and explored the preliminary mechanisms underlying their role in rabbit Achilles tendon repair.Tendon structure and functional recovery were evaluated through histological assessment, pathology, tissue hydroxyproline (Hyp) content measurement, and biomechanical testing.Then the inflammation and metabolic status of the extracellular matrix, along with potential mechanisms, were assessed through quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and immunohistochemical staining.This study demonstrated the satisfactory ability of UC-MSCs transplantation to promote functional repair of tendon in a rabbit model of tendon diseases. The mechanisms involved include upregulation of Collagen I and Collagen III expression, inhibition of MMP-9, and enhancement of muscle fiber contraction through increased expression of troponin C (TnC), thereby improving the structural stability at the site of inflammation. We concluded that UC-MSCs hold promising potential as an enhancement strategy for MSC-based therapy in tendon diseases.

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