Long-term Functional Recovery and Quality of Life after Surgical Treatment of Putaminal Hemorrhages

Perrech, Moritz; Denizci, Cemile; Dorn, Franziska; Kessler, Josef; Seibl-Leven, Matthias; Reiner, Michael; Ruge, Maximilian I.; Goldbrunner, Roland; Grau, Stefan

doi:10.1016/j.jstrokecerebrovasdis.2014.12.001

Cited by 5 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Putaminal haemorrhage accounts for 30–40 % of all cerebral haemorrhages and is responsible for various neurological symptoms, including motor paralysis, [ 1 ]. Its prognosis varies according to factors such as age, neurological severity, site and size of haematoma, complications, and choice of treatment [ 2 ]. Therefore, rehabilitation plays a major role in the improvement of activities of daily living (ADL) in patients with putaminal haemorrhage (stroke) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Potential factors, including activities of daily living, influencing home discharge for patients with putaminal haemorrhage

et al. 2016

View full text Add to dashboard Cite

BackgroundConvalescent rehabilitation wards assist stroke patients in acquiring skills for activities of daily living to increase the likelihood of home discharge. However, an improvement in activities of daily living does not necessarily imply that patients are discharged home. We investigated the characteristics of patients with putaminal haemorrhage who are discharged home following convalescence in rehabilitation wards.MethodsThe sample comprised 89 patients (58 men and 31 women) with putaminal haemorrhage hospitalised in the convalescent rehabilitation ward of our hospital between August 2012 and July 2013. Their age ranged from 29 to 88 years (61.9 ± 11.9 years). The lesion occurred on the right side in 48 and on the left in 41 patients. The mean period from onset to hospitalisation in the convalescent rehabilitation ward was 30.8 ± 17.2 days, and the mean hospitalisation period was 70.7 ± 31.8 days. We examined age, sex, haematoma volume, duration from onset to hospitalisation, neurological symptoms, cognitive function, functional independence measure, number of cohabitating family members and whether the patient lived alone before stroke, and the relationship among these factors and discharge destination (home or facility/hospital) was assessed.ResultsThe discharge destination was home for 71 and a facility or hospital for 18 patients. Differences were observed in age, haematoma volume, neurological symptoms, cognitive function, functional independence measure score on admission and discharge, number of cohabitating family members and whether the patient lived alone before stroke for patients discharged home. Patients who required long-term care and were discharged home were more likely to be living with family members who were present during daytime. Home discharge was possible if functional independence measure score was ≥70 at the time of discharge for motor items and ≥24 for cognitive items, even if a patient lived alone before stroke.ConclusionsAlthough the presence of cohabitating family members was important, the factor most strongly influencing home discharge was the patient’s activities of daily living status at the time of discharge. For patients who lived alone before stroke, physical and cognitive functions must be maintained for them to be discharged home after rehabilitation.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential factors, including activities of daily living, influencing home discharge for patients with putaminal haemorrhage

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The HS accounts for nearby 30% of all types of acute stroke and usually has poorer prognostic Ivyspring International Publisher outcomes as compared to those of IS. Additionally, acute HS (i.e., AHS) patients who required surgical intervention will frequently develop permanent disability [5][6][7][8][9][10][11]. Furthermore, there is no data as to whether the pharmacomodulation is beneficial in patients who suffer from AHS and survive with permanent disability.…”

Section: Introductionmentioning

confidence: 99%

Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke

Yip¹,

Lee²,

Li³

et al. 2020

Int. J. Biol. Sci.

View full text Add to dashboard Cite

This study tested the hypothesis that abrogated dipeptidyl peptidase-4 (DPP4) activity played a crucial role on reducing stroke volume and preserving neurological function in rodent after acute hemorrhagic stroke (AHS). Animals (n=6/each group) were categorized into group 1 (sham-control of F344 rat), group 2 (sham-control of DPP4-deficiency rat), group 3 [AHS by right cerebral injection of autologous blood (100 µL) in F344 rat], group 4 (AHS + sitagliptin/600 mg/kg 3 h prior to and at 3 h then once per day after AHS) and group 5 (AHS in DPP4-deficiency rat). The results of corner test showed the neurological function was significantly improved from days 3, 7, and 14 in groups 4 and 5 than in group 3 (all p<0.001). By days 1 and 14 after AHS procedure, the circulating levels of SDF-1α and GLP-1 were significantly increased from groups 1/2 to group 5 (all p<0.001), whereas circulating DPP4 activity was significantly increased in group 3 than other groups (all p<0.001). The brain ischemic area (BIA) was highest in group 3, lowest in groups 1/2 and significantly lower in group 5 than in group 4 (all p<0.0001). The protein expressions of oxidative-stress/inflammatory/apoptotic/cell-proliferation signaling, and the cellular expressions of inflammatory/DNA-damaged biomarkers exhibited a similar pattern to BIA among the groups (all p<0.01). In conclusion, deprivation of DPP4 activity protected the brain from AHS damage and preserved neurological function.

show abstract

“…DEMQOL and DEMQOL-Proxy [1–3] are disease-specific patient reported outcome measures (PROMs) for measuring health-related quality of life (HRQL) in people with dementia (PWD). Total scores on DEMQOL and DEMQOL-Proxy are typically used as outcomes in intervention and other evaluative studies [4, 5] or, as a measure of disease specific utility [6], in cost-effectiveness studies [7, 8]. In addition, there is growing interest in using PROMs for routine monitoring of the quality of health and social care [9–13], including dementia care [12, 13].…”

Section: Introductionmentioning

confidence: 99%

DEMQOL and DEMQOL-Proxy: a Rasch analysis among those diagnosed with dementia

Hendriks

Smith

Black

2019

Health Qual Life Outcomes

View full text Add to dashboard Cite

BackgroundIn previous work we concluded that DEMQOL and DEMQOL-Proxy can provide robust measurement of HRQL in dementia when scores are derived from analysis using the Rasch model. As the study sample included people with mild cognitive impairment, we undertook a replication study in the subsample with a diagnosis of dementia (PWD). PWD constitute the population for whom DEMQOL and DEMQOL-Proxy were originally developed.MethodsWe conducted a Rasch model analysis using the RUMM2030 software to re-evaluate DEMQOL (441 PWD) and DEMQOL-Proxy (342 family carers). We evaluated scale to sample targeting, ordering of item thresholds, item fit to the model, and differential item functioning (sex, age, severity, relationship), local independence, unidimensionality and reliability.ResultsFor both DEMQOL and DEMQOL-Proxy, results were highly similar to the results in the original sample. We found the same problems with content and response options.ConclusionsDEMQOL and DEMQOL-Proxy can provide robust measurement of HRQL in people with a diagnosis of dementia when scores are derived from analysis using the Rasch model. As in the wider sample, the problems identified with content and response options require qualitative investigation in order to improve the scoring of DEMQOL and DEMQOL-Proxy.

show abstract

Long-term Functional Recovery and Quality of Life after Surgical Treatment of Putaminal Hemorrhages

Cited by 5 publications

References 16 publications

Potential factors, including activities of daily living, influencing home discharge for patients with putaminal haemorrhage

Potential factors, including activities of daily living, influencing home discharge for patients with putaminal haemorrhage

Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke

DEMQOL and DEMQOL-Proxy: a Rasch analysis among those diagnosed with dementia

Contact Info

Product

Resources

About