Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation

Battistella, Linamara Rizzo; Imamura, Marta; Pretto, Lucas Ramos De; Cauwenbergh, Simon K H A A Van; Ramos, Vinícius Delgado; Uchiyama, Sabrina Saemy Tome; Matheus, Denise; Kuhn, Flavia; Oliveira, Ana Alice Amaral de; Naves, Gabriella Souza; Mirisola, Aline Rossetti; Ribeiro, Fernando de Quadros; Sugawara, André Tadeu; Cantarino, Mauricio; Cavalca, Rafael Andrade Santos Antunes; Pagano, Vanessa; Marques, Melina Valentim; Silva, Elizabeth Mendes da; Gomes, Alessandra Pereira; Fregni, Felipe

doi:10.1136/bmjopen-2021-057246

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…A cohort study of 318 older patients who survived hospitalization for COVID-19 showed a 36% prevalence of functional limitations 3 months after discharge. 13) Consistent with our findings, Battistela et al 14) found that 71% of COVID-19 survivors reported limitations in their daily activities 11 months post-discharge from the hospital. In addition, a Chinese ambispective cohort study including data from Values are presented as median (interquartile range) or number (%).…”

Section: Discussionsupporting

confidence: 91%

Functional Status in Older Adults following Hospitalization for COVID-19: A Cohort Study

Izaguirre,

Arakaki,

Boero

et al. 2023

Ann Geriatr Med Res

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Background: Coronavirus disease 2019 (COVID-19) can cause multiple acute complications. This study evaluated the long-term functional status of older patients hospitalized for acute COVID-19.Methods: We analyzed data from a multicenter ambispective cohort study on patients aged >60 years who were hospitalized for COVID-19 at two tertiary care hospitals in Argentina. The participants were contacted by telephone between November 2021 and September 2022 to collect data on their functional status. Ordinal logistic regression was used to identify factors associated with functional limitations after discharge.Results: Among the 374 included patients, 205 (55%) showed functional limitations, including 58 (28%) who died during follow-up. The factors independently associated with functional limitations were low baseline functional status (odds ratio [OR]=9.19; 95% confidence interval [CI], 3.35–25.17) and admission to the intensive care unit (OR=4.41; 95% CI, 2.28–8.53). Men had lower odds of functional impairment (OR=0.55; 95% CI, 0.35–0.86).Conclusion: Older patients had high mortality rates and poor functional status at 2 years post-discharge for COVID-19. Several factors at the time of discharge were associated with a higher risk of functional limitations and can be used to identify patients’ long-term needs for support and rehabilitation services.

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Section: Discussionsupporting

confidence: 91%

Functional Status in Older Adults following Hospitalization for COVID-19: A Cohort Study

Izaguirre,

Arakaki,

Boero

et al. 2023

Ann Geriatr Med Res

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“…Almost all the studies used valid study tools and criteria for the assessing persistent symptoms. For assessing one of the most common and persistent symptoms, dyspnea, tools such as Dyspnoea-12 (ID 9, 19) [ 22 , 32 ], Self-Evaluation of Breathing Questionnaire (SEBQ) (ID 12) [ 25 ], The King’s Brief Interstitial Lung Disease questionnaire (ID 33) [ 46 ], etc. were used.…”

Section: Resultsmentioning

confidence: 99%

A Scoping Review on Long COVID-19: Physiological and Psychological Symptoms Post-Acute, Long-Post and Persistent Post COVID-19

Surapaneni

Singhal

Saggu³

et al. 2022

Healthcare

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Background: The identification of persistent symptoms of chronic/long COVID-19 is crucial in understanding the management of long haulers of post COVID-19. Methods: Pub Med (Medline) database was scoped for original articles based on a search strategy related to the objectives. The selected articles post-screening were analyzed for variables relating to chronic/long COVID-19. Results were analyzed using descriptive statistics. Results: A total of 33 studies were reviewed. A total of 60% of the studies were observational studies and most of them were from high income countries. Almost half of the studies were in phase 3 of post-COVID-19, i.e., symptoms lasting >24 weeks. Among the physiological and psychological symptoms studied, fatigue, dyspnea, cough, headache, memory loss, depression, brain fog and lack of concentration were found to be the most frequently reported symptoms. Excessive sleep, constipation and neuropathic pain were among the least reported symptoms. Prior hospitalization, the female gender was found to be a risk factor. Limitations were reported by all studies. Conclusions: The major physiological and psychological symptoms of long COVID-19 have been explained with risk factors and its impact on patients’ lifestyles. The findings of this review hope to facilitate clinicians to draw conclusions to manage the long-term effects of post/chronic COVID-19.

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“…A large cohort study on over 800 people in Brazil who had been hospitalised for at least one day due to COVID-19 found that 6 months after discharge, 71% of survivors (n = 567) were experiencing limitations in their daily activities, Healthcare 2023, 11, 3085 2 of 10 and 6% (n = 45) rated this as severe. Pain and discomfort (65%), breathlessness (65%), and anxiety and depression (57%) were also reported among this cohort [7]. Abnormal mucus production, systemic inflammation, lung fibrosis, and post-viral inflammation have also been observed [4,8,9].…”

Section: Introductionmentioning

confidence: 63%

Manual Lymph Drainage for Post-COVID-19 Related Cough, Breathlessness, and Fatigue; Two Case Reports

Overall,

Langley,

Douglass

2023

Healthcare

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Background: Persistent symptoms after SARS CoV-2 infection such as fatigue, shortness of breath, and cognitive dysfunction that cannot be explained by an alternative diagnosis have been termed long COVID and present a significant emerging public health problem. Current approaches include rehabilitation and symptom management involving multiple health disciplines and as yet there are no pharmaceutical approaches other than routine symptom management. Manual lymph drainage (MLD) has been used to support recovery during pulmonary rehabilitation and reduce chronic inflammation including symptoms associated with long COVID. Case description and outcomes: Two adult females who had reported long-COVID symptoms more than 10 weeks after the resolution of the acute infection were treated with MLD by Remedial Therapists trained in the Dr Vodder method of MLD. Respiratory function (Peak Flow Meter) and blood oxygen levels (Oximeter) were recorded before and after a one-minute sit-to-stand test prior to the treatment. The Dyspnea-12 Questionnaire, the Revised Piper Fatigue Scale, and Likert scales were used to collect client-reported outcomes. Six 45-min treatments were applied weekly, with a follow-up review and treatment at three months. In both cases, all outcomes improved after the third treatment with further improvement noted at three months. Conclusions: MLD may offer a non-invasive, non-pharmaceutical approach to the resolution of long-COVID symptoms such as cough, breathlessness, and fatigue.

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Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation

Cited by 20 publications

References 33 publications

Functional Status in Older Adults following Hospitalization for COVID-19: A Cohort Study

Functional Status in Older Adults following Hospitalization for COVID-19: A Cohort Study

A Scoping Review on Long COVID-19: Physiological and Psychological Symptoms Post-Acute, Long-Post and Persistent Post COVID-19

Manual Lymph Drainage for Post-COVID-19 Related Cough, Breathlessness, and Fatigue; Two Case Reports

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