There have been consistent efforts to assess treatment effect heterogeneity (TEH) of Head Start using the data from the Head Start Impact Study (HSIS), a randomized controlled trial of a federally funded child development program for a nationally representative sample of low-income parents and their 3- and 4-year-old children in the United States. Including 28 studies on TEH of Head Start, this review found that multiple high-risk subgroups (e.g., children with lower cognitive abilities, Spanish-speaking dual language learners) experienced larger gains across a range of developmental and parental outcomes, but mixed results for several subgroups. Most studies focused on subgroup analyses, cognitive and social-emotional outcomes, and short-term effects. Further studies on distributional effects, health and parental outcomes, and long-term effects are warranted. Finally, suggestions for future research on TEH of Head Start are discussed, which are applicable to other child development programs and policy evaluations.