Long‐term health‐related quality of life in living liver donors: A south Asian experience

Abstract

Living donor hepatectomy is safe with acceptable morbidity and excellent long-term HRQOL with no change in career path or significant alteration of lifestyle for donors.

Prevalence and Predictors of Patient-Reported Long-term Mental and Physical Health After Donation in the Adult-to-Adult Living-Donor Liver Transplantation Cohort Study

“…77–80 Nevertheless, bereaved donors almost universally state that they take comfort in having done all they could and they have no regrets about having donated. 13,14,20,77,78 Additionally, we previously reported very low average levels of perceived guilt or responsibility for the recipient’s death in our cohort, 14 and other liver donor follow-up studies have not found recipient death to increase risk for adverse long-term general HRQOL. 18,20,21 Moreover, the experience of grief following bereavement does not necessarily mean that an individual will meet criteria for a psychiatric disorder, including the conditions we assessed; in fact, a large empirical literature shows that the vast majority of bereaved individuals do not develop any psychiatric disorder.…”

“…First, studies of these long-term psychosocial outcomes have been predominantly cross-sectional 12–22 and, as such, have been unable to examine trends over time. Second, most reports do not examine clinically significant difficulties in the psychosocial domains assessed, and instead focus on either nonspecific, generic HRQOL assessments 13,21,23 or unvalidated, single-item assessments with unknown performance characteristics. 12,15–20 Third, the clear majority of reports examine small single-site cohorts, 12,13,15–20,22 resulting in findings of unknown, potentially limited, generalizability.…”

Long‐term follow‐up of living liver donors

“…[5,10,25,36,37] In addition, several reports have shown that the HRQoL in donors is, on average, above the normative levels in the long term. [5,15,16,24,25,[44][45][46] A multicenter prospective study showed that the HRQoL of living liver donors was not negatively affected by donation up to 11 years after liver transplant. [5] Our results support the findings published in these studies; however, in our study, we compared liver donors with potential donors rather than with the general population.…”

“…[ 5,10,25,36,37 ] In addition, several reports have shown that the HRQoL in donors is, on average, above the normative levels in the long term. [ 5,15,16,24,25,44–46 ] A multicenter prospective study showed that the HRQoL of living liver donors was not negatively affected by donation up to 11 years after liver transplant. [ 5 ]…”