Long-Term Health-Related Quality of Life After Aneurysmal Subarachnoid Hemorrhage

Visser-Meily, J. M. A.; Rhebergen, Marloes L.; Rinkel, Gabriël J.E.; Zandvoort, Martine J. van; Post, Marcel W M

doi:10.1161/strokeaha.108.531277

Cited by 162 publications

(75 citation statements)

References 9 publications

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“…30 A Dutch cross-sectional questionnaire study of 141 patients, living independently after aSAH, reported 23% depression risk after aSAH according to Hospital Anxiety and Depression Scale. 32 This corresponds to the 20% risk of antidepressant use in patients with no symptoms after sIA-SAH according to mRS in our study.…”

Section: Strokesupporting

confidence: 50%

Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage

Huttunen

Lindgren

Kurki

et al. 2016

Stroke

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Background and Purpose-To elucidate the predictors of antidepressant use after subarachnoid hemorrhage from saccular intracranial aneurysm (sIA-SAH) in a population-based cohort with matched controls. Methods-The Kuopio sIA database includes all unruptured and ruptured sIA cases admitted to the Kuopio University Hospital from its defined catchment population in Eastern Finland, with 3 matched controls for each patient. The use of all prescribed medicines has been fused from the Finnish national registry of prescribed medicines. In the present study, 2 or more purchases of antidepressant medication indicated antidepressant use. The risk factors of the antidepressant use were analyzed in 940 patients alive 12 months after sIA-SAH, and the classification tree analysis was used to create a predicting model for antidepressant use after sIA-SAH. Results-The 940 12-month survivors of sIA-SAH had significantly more antidepressant use (odds ratio, 2.6; 95% confidence interval, 2.2-3.1) than their 2676 matched controls (29% versus 14%). Classification tree analysis, based on independent risk factors, was used for the best prediction model of antidepressant use after sIA-SAH. Modified Rankin Scale until 12 months was the most potent predictor, followed by condition (Hunt and Hess Scale) and age on admission for sIA-SAH. Conclusions-The sIA-SAH survivors use significantly more often antidepressants, indicative of depression, than their matched population controls. Even with a seemingly good recovery (modified Rankin Scale score, 0) at 12 months after sIA-SAH, there is a significant risk of depression requiring antidepressant medication. (Stroke. 2016;47:2242-2248.

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Section: Strokesupporting

confidence: 50%

Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage

Huttunen

Lindgren

Kurki

et al. 2016

Stroke

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“…Clinical reports vary markedly in description of sustained anxiety disorders in SAH patients, with incidence estimates ranging from 0 to 40 % [30][31][32][33]. While the wide range in anxiety disorder prevalence may be due to methods of assessing anxiety and patient age [34], preclinical data from this study and other reports indicate that both severity and location of hemorrhage also may be contributory.…”

Section: Discussionmentioning

confidence: 62%

Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats

et al. 2016

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Background Cognitive dysfunction can be a long-term complication following subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized to emulate this disorder. This study was designed to directly compare long-term cognitive deficits in the context of similar levels of insult severity in the cisterna magna double-blood (DB) injection versus prechiasmatic blood (PB) injection SAH models. Methods Pilot work identified blood injectate volumes necessary to provide similar mortality rates (20-25 %). Rats were then randomly assigned to DB or PB insults. Saline injection and naïve rats were used as controls. Functional and cognitive outcome was assessed over 35 days. Results DB and PB caused similar transient rotarod deficits. PB rats exhibited decreased anxiety behavior on the elevated plus maze, while anxiety was increased in DB. DB and PB caused differential deficits in the novel object recognition and novel object location tasks. Morris water maze performance was similarly altered in both models (decreased escape latency and increased swimming speed). SAH caused histologic damage in the medial prefrontal cortex, perirhinal cortex, and hippocampal CA1, although severity of injury in the respective regions differed between DB and PB. Conclusion Both SAH models caused long-term cognitive deficits in the context of similar insult severity. Cognitive deficits differed between the two models, as did distribution of histologic injury. Each model offers unique properties and both models may be useful for study of SAH-induced cognitive deficits.

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“…7 Furthermore, an individual's perception and establishment of goals and expectations are undoubtedly influenced by personal characteristics such as optimism, psychic stability, and confidence. 36 Not only were mental and personality functions identified as powerful determinants of HRQoL already in previous studies, [37][38][39] but the relationship between HRQoL and gait as well as activities of daily living (ADL), including housework, were also identified as determinants. 40,41 This association was in the chronic phase after stroke.…”

Section: Discussionmentioning

confidence: 96%

Factors Associated With Health-Related Quality of Life After Stroke

Algurén

Fridlund

Cieza

et al. 2011

Neurorehabil Neural Repair

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Background. In line with patient-centered health care, it is necessary to understand patients’ perceptions of health. How stroke survivors perceive their health at different time points after stroke and which factors are associated with these feelings provide important information about relevant rehabilitation targets. Objective. This study aimed to identify the independent factors of health-related quality of life (HRQoL) from a biopsychosocial perspective using the methods of multivariate regression at 3 different time points poststroke. Methods. Included in the study were 99 patients from stroke units with diagnosed first-ever stroke. At admission and at 6 weeks, 3 months, and 1 year poststroke, HRQoL was assessed using the EuroQoL-5D Visual Analogue Scale (EQ-5D VAS). Consequences in Body Functions and Activities and Participation, and Environmental Factors were documented using 155 categories of the International Classification of Functioning, Disability and Health (ICF) Core Set for Stroke. Results. For a period of 1 year, problems with recreation and leisure, personality functions, energy and drive functions, and gait pattern functions were repeatedly associated with worse HRQoL. Whereas Body Functions and Activities and Participation explained more than three-fourths of the variances of HRQoL at 6 weeks and 3 months (R2 = 0.80-0.93), the variation at 1 year was best explained by either Body Functions or Environmental Factors (R2 = 0.51). Conclusions. The results indicate the importance of Body Functions and Activities and Participation (mainly personality functions and recreation and leisure) on HRQoL within 3 months poststroke, but increased impact of Environmental Factors on HRQoL at 1 year.

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Long-Term Health-Related Quality of Life After Aneurysmal Subarachnoid Hemorrhage

Cited by 162 publications

References 9 publications

Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage

Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage

Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats

Factors Associated With Health-Related Quality of Life After Stroke

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