Long-Term Health Symptoms and Sequelae Following SARS-CoV-2 Infection: An Evidence Map

Franco, Juan Víctor Ariel; Garegnani, Luis; Oltra, Gisela Viviana; Metzendorf, Maria‐Inti; Trivisonno, Leonel Fabrizio; Sgarbossa, Nadia; Ducks, Denise; Heldt, Katharina; Mumm, Rebekka; Barnes, Benjamin; Scheidt‐Nave, Christa

doi:10.3390/ijerph19169915

Cited by 33 publications

(40 citation statements)

References 37 publications

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“…In contrast, the set of complaints in the group of patients with persisting complaints is respiratory symptoms, neurological symptoms, fatigue, pain, mental dysfunction, cardiovascular dysfunction, post-exertion symptoms, and cognitive dysfunction. Furthermore, the early onset of orthostatic intolerance symptoms has been described [ 5 , 6 , 7 ]. The name of this set of persisting complaints has not yet been clearly defined and is called “long” COVID, long-haul COVID, chronic COVID, post-COVID syndrome and even post-acute sequelae of a SARS-CoV-2 infection (PASC) [ 1 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the early onset of orthostatic intolerance symptoms has been described [ 5 , 6 , 7 ]. The name of this set of persisting complaints has not yet been clearly defined and is called “long” COVID, long-haul COVID, chronic COVID, post-COVID syndrome and even post-acute sequelae of a SARS-CoV-2 infection (PASC) [ 1 , 7 ]. In this study, we use the term “long-haul” COVID.…”

Section: Introductionmentioning

confidence: 99%

“…Despite a vast number of studies, the time interval between the onset of the infection and the adjudication of patients to the long-haul COVID group is not established. Intervals vary between 4 weeks and 3 months according to the WHO, CDC, NICE, and AWMF [ 7 ]. Interestingly, there does not seem to be a relationship with the severity of the SARS-CoV-2 infection [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Campen¹,

Visser²

2022

Healthcare

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Background: As complaints of long-haul COVID patients are similar to those of ME/CFS patients and as orthostatic intolerance (OI) plays an important role in the COVID infection symptomatology, we compared 14 long-haul COVID patients with 14 ME/CFS patients with a post-viral Ebstein-Barr (EBV) onset and 14 ME/CFS patients with an insidious onset of the disease. Methods: In all patients, OI analysis by history taking and OI assessed during a tilt test, as well as cerebral blood flow measurements by extracranial Doppler, and cardiac index measurements by suprasternal Doppler during the tilt test were obtained in all patients. Results: Except for disease duration no differences were found in clinical characteristics. The prevalence of POTS was higher in the long-haul patients (100%) than in post-EBV (43%) and in insidious-onset (50%) patients (p = 0.0002). No differences between the three groups were present in the prevalence of OI, heart rate and blood pressure changes, changes in cerebral blood flow or in cardiac index during the tilt test. Conclusion: OI symptomatology and objective abnormalities of OI (abnormal cerebral blood flow and cardiac index reduction during tilt testing) are comparable to those in ME/CFS patients. It indicates that long-haul COVID is essentially the same disease as ME/CFS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Campen¹,

Visser²

2022

Healthcare

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“…Most studies focused on the prevalence of individual symptoms (e.g., anosmia, fatigue, etc.). In this systematic review, we aim to describe the findings of studies assessing key outcomes related to wellbeing and recovery in children and adolescents using the evidence derived from our evidence map [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Short and Long-Term Wellbeing of Children following SARS-CoV-2 Infection: A Systematic Review

Franco

Garegnani²,

Oltra³

et al. 2022

IJERPH

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Post-COVID conditions in children and adolescents were mostly investigated as the incidence of individual or clusters of symptoms. We aimed to describe the findings of studies assessing key outcomes related to global wellbeing and recovery in children and adolescents from a public health perspective. We searched the Cochrane COVID-19 Study Register and WHO COVID-19 Global literature on coronavirus disease database on 5 November 2021 and tracked ongoing studies published after this date. We included observational studies on children and adolescents with a follow-up greater than 12 weeks and focused on the outcomes of quality of life, recovery/duration of symptoms, school attendance and resource use/rehabilitation. We assessed their methodological quality, and we prepared a narrative synthesis of the results. We included 21 longitudinal and 4 cross-sectional studies (6 with a control group) with over 68 thousand unvaccinated children and adolescents with mostly asymptomatic or mild disease. Study limitations included convenience sampling, a poor description of their study population and heterogeneous definitions of outcomes. Quality of life was not largely affected in adolescents following COVID-19, but there might be greater impairment in young children and in those with more severe forms of the disease (4 studies). There might also be an impairment in daily activities and increased school absenteeism following COVID-19, but the findings were heterogeneous (5 studies). A total of 22 studies provided highly variable estimates based on heterogeneous definitions of overall persistence of symptoms (recovery), ranging from 0 to 67% at 8–12 weeks and 8 to 51% at 6–12 months. We found limited data on resource use and the need for rehabilitation. One controlled study indicated that the quality of life of infected children and adolescents might not substantially differ from controls. All controlled studies found a higher burden of persistent symptoms in COVID-19 cases compared with test-negative controls or cases of influenza. There is limited evidence on the short and long-term well-being of children following SARS-CoV-2 infection. High-quality longitudinal studies with control groups are needed to describe the outcomes in this population, especially in vaccinated children and those affected by new variants of the virus.

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“…However, these approaches fail to address less severe non-hospital demanding cases and may thus underestimate risk of infection. Considering reports on delayed return to work 17 and of post Covid-19 conditions with persistent ill health following cases without acute critical disease 18 , this is of importance not the least in occupations with many young and healthy employees who are less likely to be hospitalized but at equal or higher risk of infection.…”

Section: Introductionmentioning

confidence: 99%

Occupational risk of SARS-CoV-2 infection: a nationwide register-based study of the Danish workforce during the Covid-19 pandemic 2020-21

Bonde

Begtrup

Jensen

et al. 2022

Preprint

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(word count 246) Objectives Most earlier studies of occupational risk of Covid-19 covering the entire workforce are based on relatively rare outcomes such as hospital admission and mortality. This study examines the incidence of SARS-CoV-2 infection by occupational group based upon real-time polymerase chain reaction tests (RT-PCR). Methods The cohort includes 2.4 million Danish employees, 20-69 years of age. All data were retrieved from public registries. The sex-specific incidence rate ratios (IRR) of first-occurring positive RT-PCR test from week 8 of 2020 through week 50 of 2021 were computed by Poisson regression for each 4-digit DISCO-08 job code with more than 100 employees (337 in men; 297 in women). Occupational groups with low risk of workplace infection according to a job exposure matrix constituted the reference group. Risk estimates were adjusted by demographic, social and health characteristics including household size, completed Covid-19 vaccination, pandemic wave and occupation-specific frequency of testing. Results The IRR of a SARS-CoV-2 infection was elevated in 34 occupations comprising 12 % of male employees and 45 occupations comprising 41 % of female employees. All IRR estimates were below 2.0. Decreased IRRs were observed in 85 occupations in men but none in women. Discussion We observed a modestly increased risk of SARS-CoV-2 infection among employees in numerous occupations indicating a large potential for prevention actions, especially in the female workforce. Cautious interpretation of observed risk in specific occupations is needed because of methodological issues inherent in analyses of RT-PCR-test results and because of multiple statistical tests.

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Long-Term Health Symptoms and Sequelae Following SARS-CoV-2 Infection: An Evidence Map

Cited by 33 publications

References 37 publications

Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Short and Long-Term Wellbeing of Children following SARS-CoV-2 Infection: A Systematic Review

Occupational risk of SARS-CoV-2 infection: a nationwide register-based study of the Danish workforce during the Covid-19 pandemic 2020-21

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