Long-term hematological consequences of sulfur mustard on civilians of Sardasht 20 years after exposure

“…Malignant effects related to autoimmunity have also been reported in earlier publications (7). Based on our previous studies, the serum proinflammatory cytokine (TNF, IL-1α, IL-1β and IL-1Ra) levels were significantly lower in the SM-exposed group than in the unexposed controls (8) and we also found significantly different hematological parameters (Hematocrit (HTC), Mean Cell Volume (MCV), Red Blood Count (RBC), White Blood Count (WBC), Platelet Count (PLT) and Polymorphonuclear Leukocyte (PMN)) between the SM-exposed group and unexposed controls (6). In another study, we investigated the association between total serum bilirubinemia and intensity of SM exposure.…”

Section: Introductionmentioning

confidence: 71%

“…The long-term effects of SM exposure manifest in several health-related problems later in life, however the pathophysiology of SMinduced complications is not clear and requires further conclusive investigations (2). The most damaging symptoms reported in casualties were related to the lungs (3), eyes (4), skin (5) and hematologic system (6). Malignant effects related to autoimmunity have also been reported in earlier publications (7).…”

Section: Introductionmentioning

confidence: 78%

“…Blood samples of 372 SM-exposed individuals and 128 controls were analyzed for hematological parameters in our previous study (6) and their results are summarized 2…”

Section: Resultsmentioning

confidence: 99%

“…2017; 22(6):e39192. a Hematological parameters were assessed and a comparison was undertaken between the exposed and control groups (6). Data are presented as Mean ± SD.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Nadoushan¹,

Mahdavi²,

Soroush³

et al. 2016

Trauma Mon

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Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration does not significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α, IL-1β, IL-1Ra, Tumor Necrotizing Factor (TNF)-α and IL-6 with serum bilirubin concentration was investigated. Methods: Overall, 368 individuals, who were exposed to SM in 1986, and 127 non-exposed control participants were studied in the context of hematological factors, serum bilirubin and inflammatory cytokines. Total serum bilirubin and direct bilirubin were analyzed using an enzymatic method, while the inflammatory cytokines were evaluated by enzyme linked immunosorbent assay (ELISA). Results:The concentration of inflammatory cytokines in the exposed group was significantly different compared to the control group, however the serum concentrations of total and direct bilirubin did not differ between the two groups. Among cytokines, other than the relationship between the IL-6 concentrations and bilirubin level, there were no significant correlations between the levels of other cytokines with direct and total bilirubin. Conclusions: Considering the lack of correlation between bilirubin concentrations and levels of inflammatory cytokines other than IL-6, we should identify other confounding factors for lack of increase in bilirubin in SM casualties, despite the observed hemolysis.

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Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Ghazanfari

Yaraee

Kariminia

et al. 2009

International Immunopharmacology

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Long-term hematological consequences of sulfur mustard on civilians of Sardasht 20 years after exposure

Cited by 19 publications

References 8 publications

Serum soluble Fas ligand and nitric oxide in long-term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study

Serum soluble Fas ligand and nitric oxide in long-term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

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