Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice

Altherr, Everett B.; Rainwater, Aundrea; Kaviani, Darian; Tang, Qijun; Güler, Ali D.

doi:10.1016/j.bbr.2021.113470

Cited by 17 publications

(13 citation statements)

References 38 publications

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“…When mice were returned to an exclusively chow diet after extended HFD access, both mHFD and mLFD groups exhibited pronounced weight loss and reduced caloric intake ( Figure 1 K-N). This is consistent with previous reports in which mice reduce chow intake following access to highly palatable foods [ 45 , 46 ], suggesting mHFD mice retain sensitivity to chow devaluation. Such weight loss may be driven by a reduction in basal metabolic rate and energy expenditure [ 47 , 48 ].…”

Section: Discussionsupporting

confidence: 93%

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Shrivastava¹,

Swaminathan²,

Barlotta³

et al. 2023

Molecular Metabolism

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Section: Discussionsupporting

confidence: 93%

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Shrivastava¹,

Swaminathan²,

Barlotta³

et al. 2023

Molecular Metabolism

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“…Another tentative explanation might be that Ex4 fails to reduce aggression as HFD reduces the reward thereof. Supportively, HFD exposure decreases rewards like palatable foods intake and drug reward [49][50][51]. Supportively, Ex4 does not alter the intake of foods considered rewarding (HFD) in the present study.…”

Section: Procedures Protocolsupporting

confidence: 68%

“…Exposure to high-fat diets (HFD) reduces preference for palatable foods, depression-like behaviors and drug reward, a decline plausibly involving altered dopaminergic neurotransmission [49][50][51]. Besides, in male mice HFD enhances aggression [52] and impairs the responsiveness to GLP-1 on various behaviors [53][54][55].…”

Section: Introductionmentioning

confidence: 99%

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

et al. 2022

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Aggression is a complex social behavior, which is provoked in the defense of limited resources including food and mates. Recent advances show that the gut-brain hormone ghrelin modulates aggressive behaviors. As the gut-brain hormone glucagon-like peptide-1 (GLP-1) reduces food intake and sexual behaviors its potential role in aggressive behaviors is likely. Therefore, we investigated a tentative link between GLP-1 and aggressive behaviors by combining preclinical and human genetic-association studies. The influence of acute or repeated injections of a GLP-1 receptor (GLP-1R) agonist, exendin-4 (Ex4), on aggressive behaviors was assessed in male mice exposed to the resident-intruder paradigm. Besides, possible mechanisms participating in the ability of Ex4 to reduce aggressive behaviors were evaluated. Associations of polymorphisms in GLP-1R genes and overt aggression in males of the CATSS cohort were assessed. In male mice, repeated, but not acute, Ex4 treatment dose-dependently reduced aggressive behaviors. Neurochemical and western blot studies further revealed that putative serotonergic and noradrenergic signaling in nucleus accumbens, specifically the shell compartment, may participate in the interaction between Ex4 and aggression. As high-fat diet (HFD) impairs the responsiveness to GLP-1 on various behaviors the possibility that HFD blunts the ability of Ex4 to reduce aggressive behaviors was explored. Indeed, the levels of aggression was similar in vehicle and Ex4 treated mice consuming HFD. In humans, there were no associations between polymorphisms of the GLP-1R genes and overt aggression. Overall, GLP-1 signaling suppresses acquisition of aggressive behaviors via central neurotransmission and additional studies exploring this link are warranted.

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“…This is supported by previous findings that rats fed a HF diet had decreased motivation for an appetitive reward if first exposed to the reward during the testing period, but not when animals were repeatedly presented with the reward in their home cage before the start of testing [ 67 ]. More recently, it has been reported that mice switched to a low-fat diet after 10 weeks of HF feeding showed higher consumption of a food reward compared to the intake before the dietary switch [ 68 ]. This suggests that timing of reward presentation affects its incentive salience in HF-fed animals.…”

Section: Discussionmentioning

confidence: 99%

Appetitive Motivation and Associated Neurobiology Change Differentially across the Life Course of Mouse Offspring Exposed to Peri- and Postnatal High Fat Feeding

2022

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Alterations in neural pathways that regulate appetitive motivation may contribute to increased obesity risk in offspring born to mothers fed a high fat (HF) diet. However, current findings on the impact of maternal obesity on motivation in offspring are inconclusive, and there is no information about the long-lasting effects in aged animals. This study examined the longitudinal effect of perinatal and chronic postnatal HF intake on appetitive motivation in young and aged offspring. Female C57Bl/6 were fed either a control (C) or HF diet before mating through to lactation. At weaning, offspring were maintained on the C or HF diet, generating the following four diet groups: C/C, C/HF, HF/C, and HF/HF based on the pre/post weaning diet. At 6 months, motivation was higher in HF/C females, but lower in male and female C/HF and HF/HF mice. By 12 months, this difference was lost, as C-fed animals became less motivated, while motivation increased in HF-fed mice. The mRNA levels of dopamine receptor 1 and 2 increased with age, while cannabinoid receptor 1 and μ-opioid receptor expression remained stable or decreased in mesolimbic and mesocortical dopaminergic pathways. Results from this study suggest that perinatal and chronic postnatal HF feeding produced opposite effects on appetitive motivation in young adult offspring mice, which was also reflected in the shift in motivation over time. These results have significant implications for patterns of hedonic eating across the life course and the relative risk of obesity at different time points.

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Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice

Cited by 17 publications

References 38 publications

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

Appetitive Motivation and Associated Neurobiology Change Differentially across the Life Course of Mouse Offspring Exposed to Peri- and Postnatal High Fat Feeding

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